LINA MARÍA HERRERA AGUDELO

STUDENT MEDICINE

Satellite repeats is not only a inactive part of our genome, their levels are

increased in cancer especially HSATII and

ALR

The tumor suppressor protein p53 This protein

induces apoptosis of cancerous cells, impedes the proliferation of cells that have self-repairing

capacity in this way tissues can be reparated.

OVEREXPRESSION OF REPETITIVE DNA SEQUENCES DISCOVERED IN COMMON TUMOR CELLS Sciencedaily (jan. 13, 2011)

 

Satellite repeats make up a large part of our genome but, had been thought to be inactive

It was found that these DNA are very active in cancer but not in normal tissue.

OVEREXPRESSION OF REPETITIVE DNA SEQUENCES DISCOVERED IN COMMON TUMOR CELLS Sciencedaily (jan. 13, 2011)

 

Using a mouse model of pancreatic, colon and lung cancer, it will be evidenced the increase of satellite repeats. the investigation team proved the importance of these DNA sequence into this malignant process.

OVEREXPRESSION OF REPETITIVE DNA SEQUENCES DISCOVERED IN COMMON TUMOR CELLS Sciencedaily (jan. 13, 2011)

 

Studies on human tumors were similar results, there were overexpression of two satellites called, HSATII and ALR.

It supposed that satellites expression begins early in tumor development.

OVEREXPRESSION OF REPETITIVE DNA SEQUENCES DISCOVERED IN COMMON TUMOR CELLS Sciencedaily (jan. 13, 2011)

 

Although actually biopsy is the principal diagnoses method, satellite RNA expression may provide better and specific biomarker of epithelial cancers.

OVEREXPRESSION OF REPETITIVE DNA SEQUENCES DISCOVERED IN COMMON TUMOR CELLS Sciencedaily (jan. 13, 2011)

 

P53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)  

Using wing primordium of the fruit fly as a model, professor Marco Milán demonstrated that the organs control their proportion, by molecular mechanism.

p53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)  

During the embryonic process, organs establish their proportions and this is vital for the correct body function.

Alterations in the mechanisms responsible for these processes cause fatal errors in embryos and even cause their death.

P53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)  

The tumor suppressor protein p53 is activated in response to stress, such as that caused by oncogenic mutations, chemical agents.

This protein induces the death of cell which the stress has caused irreversible damage and that can become cancerous.

P53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)  

The study prove that stressed cells send signals to the remaining tissues in order to reduce their growth in order to allow damaged tissue to repair itself and allow the organ to grow in a coordinated manner.

P53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)  

This observation indicates that this protein is crucial for the coordinated growth of the different parts of an organ.

P53 DETERMINES ORGAN SIZE Molecular & cell biology (dec. 15, 2010)  

These studies are important to medicieneBecause:

They give novel cancer biomarkers. They provide new knowledge about

cancer behave. they show excellent alternatives to

create better diagnoses methods.

ScienceDaily, Your source for the lastests research news, United States.[Index].

 Biology news net. United States. [Index]

 MARTINEZ S, Lina María. Biología Molecular. 6 ed. Medellín .UPB. Facultad de Medicina, 2011. p 42-54