Post on 05-Dec-2014
description
Síntesis de Proteínas
La síntesis de proteínas se da en el Reticulo Endoplasmico rugoso.
Traducción: Paso de mRNA a Proteína.
DNA
RNA
Proteína
tRNA
Ribosoma(rRNA)
Inicio de la traducción
Elongación
Elongación
Elongación
Termino
Inicio de la traducción
Elongación
Termino
INHIBITOR SPECIFIC EFFECTActing only on bacteriaTetracycline blocks binding of aminoacyl-tRNA to A-site
of ribosomeStreptomycin prevents the transition from initiation
complex to chain-elongating ribosome and also causes miscoding
Chloramphenicol blocks the peptidyl transferase reaction on ribosomes
Erythromycin blocks the translocation reaction on ribosomes
Rifamycin blocks initiation of RNA chains by binding to RNA polymerase (prevents RNA synthesis)
Acting on bacteria and eucaryotesPuromycin causes the premature release of nascent
polypeptide chains by its addition to growing chain end
Actinomycin D binds to DNA and blocks the movement of RNA polymerase (prevents RNA synthesis)
Acting on eucaryotes but not bacteriaCycloheximide blocks the translocation reaction on
ribosomesAnisomycin blocks the peptidyl transferase reaction on
ribosomesα-Amanitin blocks mRNA synthesis by binding
preferentially to RNA polymerase II
Degradación de Proteínas
Proteosoma
Regulación de síntesis de proteínas
Plegamiento