(2)...Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009 Nishino et al., EMBO J. 32:...

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Transcript of (2)...Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009 Nishino et al., EMBO J. 32:...

Page 1: (2)...Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009 Nishino et al., EMBO J. 32: 424-436, 2013 Hori et al., J. Cell Biol. 200: 45-60, 2013 DNA QTL Mollah et al ...

1 (1)

3

1

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(2)

Page 2: (2)...Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009 Nishino et al., EMBO J. 32: 424-436, 2013 Hori et al., J. Cell Biol. 200: 45-60, 2013 DNA QTL Mollah et al ...

(3)

multi-disciplinary

,

(4)

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Huang, Kurata, , 2012; Shang,

., 2010 2008 7

2013 3 80 x 1012

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Hori et al., Cell, 2008; Amano et al., J. Cell Biol., 2009

Nishino et al., EMBO J. 32: 424-436, 2013 Hori et al., J.

Cell Biol. 200: 45-60, 2013 DNA

QTL Mollah et al. Neural Processing Letters, 2007

Fujisawa & Eguchi, Journal of Multivariate Analysis, 2008

Ninomiya & Fujisawa, Biometrics, 2007

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QTL 21

2008; Kuriki, Harushima, Fujisawa & Kurata, Annals of the Institute of Statistical

Mathematics, 2014

Fujisawa, H., Horiuchi, Y., Harushima, Y., Takada, T., Eguchi, S.,

Mochizuki, T., Sakaguchi, T., Shiroishi, T. and Kurata, N., BMC Bioinformatics, 2009

QTL Dou, Kuriki,

Maeno, Takada & Shiroishi, Biometrical Journal, 2014 P

P P

Fujisawa, H. and

Sakaguchi, T., TEST, 2012

(Dou, Kuriki, Lin & Richards, Computational

Statistics & Data Analysis, in press

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1

1

II

I Takada

et al., Genome Res.,2013[ 2013.6.7 ]

Oka et al., PLos Genetics, 2014

Dou X et al., Biom. J.2014 2

Mamm. genome 2012; Exp. anim.2012 CT

Roy S et al. Med. Image Comput. Comput-Assist.

Interv. 2013 Tamura et al. Hum. Mol. Genet.,2013

DuoMouse

(Arakawa, Takahashi, Shiroishi, Tsuchiya, Koide Journal of Neuroscience Methods 2014)

http://www.nig.ac.jp/labs/MGRL/DuoMouse.html)

http://www.at-s.com/news/detail/1049459354.html

Kato, Kuriki, Koide Heredity,

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2014; Takahashi, Koide PLoS ONE 2014; Goto, Shiroishi, Koide Genes Brain Behav, 2013;

Umemori, Uno, Koide BMC Genomics, 2013

Takada et al., Genome Res.,2008, Oka et al., Genetics, 2007,

Amano et al.,Dev. Cell, 2009, Oka et al., PLos Genetics, 2013 CT

DuoMouse

DuoMouse

2013-2014 Takahashi

et al., Behav Genet.,2006, Mamm. Genome,2008, Behav. Genet.,2009, Umemori et al. BMC

Genetics, 2009 SNEP

Fujisawa et al., BMC Bioinfo.,2009 Mizuta et al., PNAS

2010 Huang, Kurata, Wang, Wei,et al.,

Nature,2012

GWAS genome-wide association study GWAS

e-QTL

Gal4

2013

Umeda et al., Neurosci Res, 2013; Wada et al., PNAS, 2013; Kishimoto et al., Nature Neurosci, 2013;

Asakawa et al., Frontiers in Neural Circuits, 2013; Muto et al., Frontiers in Neural Circuits, 2013;

Banjoet al. Nature Comm, 2013; Wada et al. Curr Biol, 2013; Satou et al. Development 2013; Kwon

et al. Development 2013; Nakayama et al. Mech Dev 2013; Sittaramane et al. Dev Biol, 2013

CRISPR/Cas9

Cas9 50

Kondo & Ueda, Genetics, 2013

(6)

1

4

LASSO

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2 (1)

3

DNA

DNA

4

3

(a)

(b) LASSO

(c)

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(a) 2

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e-QTL

association

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(d) RNAi knock-down

CRISPR/Cas9 -

(2) 25

3

25

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LASSO QTL

GWAS

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1 4 DNA

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H25

LASSO QTL

H25 3

2

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Graphical LASSO

LASSO QTL

H22 26

Web

web Web

28

3

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Dou Xiaoling

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( ) Dou Xiaoling

4 3

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Illumina HiSeq2000

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BGI 1

100 1

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HiSeq2500

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150bpx2 180Gb 40

DNA

4

DNA

HiSeq 5 MiSeq 3 PacBio RSII 1 ABI3730

6

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180Gb/40hrs 150bp

112Tb

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