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CAP II Water System Walk-up Unit in PRB 1169M

Final plans are underway to install a "walk-up" CAPII water system fromMillipore (ELIX Advantage 10) on the first floor, south end, RM 1169M,

near the LN2 Dewar fill station.

This unit will serve researchers with intermittent, small volume needs.The production rate of the unit will be 10 liters per hour with a storagecapacity of 60 liters. Additional details of the ELIX Advantage 10 can befound in the Millipore product brochure that follows.

- Location of room 1169M -

- Anticipated wall-mounted configuration -

1169M

ELIX10MODULE

RESERVOIR (60 liter)

DISPENSINGSTATION



ADVANCING LIFE SCIENCE TOGETHERTM

Research. Development. Production.

Te Best Pure Water

Elix® Advantage System



Elix AdvAnTAgE SySTEm

THE PURE WATERYOU’VE ALWAYS

IMAGINED

mpore’s m-Q® water as orepresete te aborator staarfor utrapure water. now, we’ecocetrate our epertse teew E® Aatae sste tobr ou te best pure watertecoo, we sutaeousras te bar for pure water quat te arketpace.

Take your pure water to new heightswith the E Aatae system. Thisnew system provides pure water tomeet the most rigorous standards of regulatory bodies around the world.Combining Millipore’s patented Elixelectrodeionization technology with themost advanced purification technologies,the Elix Advantage system uses

potable tap water as feed to produceconsistently high quality pure water forall your lab’s pure water needs.And that’s not all… the advancedergonomics of the system’s E-POd® (E water Pot-of-deer)unit letyou benefit comfortably from efficientand reliable pure water delivery, where you need it, when you need it.



THE BESTIN PUREWATERTO mEET ThE mOST dEmAnding nEEdS

get te best wt te ew E Aataewater purfcato sste:

pure water tat eets te eststaars, toeter wt a eroocstate-of-te art water spessste. Peace of a ease of use—a oe!

Consistency and reliability in pure waterquality is crucial in laboratory applications.Regulatory bodies have defined the minimumquality requirements through specific andrigorous standards. The Elix Advantage systemis designed to meet or exceed requirementsas described by ISO® 3696 (Grade 2 water);ASTM® D1193 (Type II resistivity and TOCTable I specifications); and by the United States,European and Japanese Pharmacopeias forPurified Water.

The Elix Advantage system combines patented,state-of-the-art Elix electrodeionizationtechnology with the best purificationtechnologies (Progard® pretreatment, advancedreverse osmosis, 254 nm UV lamp) to providethe ideal solution for every lab using purewater—from a few liters to several hundredliters per day.

The system’s pressurized pure water is deliveredby independent E-POD water dispensers. Up tothree E-POD units per system can be placedat convenient locations in the lab for easy andflexible water delivery.

Consistent aterualit at optuoperat cost

• Elix technology• Optimized

pretreatment andreverse osmosis

• Pure waterrecirculation

• UV lamp to maintainlow bacteria levels

Exceptional ergonomic design,wt E-POd uts for eas, coeet

water spes

• Pressurized pure water where you need it• Manual or volumetric dispensing• Important information at a glance• Compact water production unit adapted to

laboratory space constraints

Modular, easil adaptable sstem to eoe wt te caes ourab—toa a toorrow

• Up to three E-POD units per system• Two dispensing flow rates• Final filters to match specific applications



SAVING YOUTIME AND

MONEYmpore’s uque a patete Elix module

s at te eart of te ew E Aatae

sste— ou benefits that count.

Toorrow’s tecoo—toa

The Elix Advantage system is the only systemavailable today that uses electrodeionization

technology in a way that is dependable, efficient androbust. Superior, proven E tecoo pro

, cosstet water quat at optuoperat costs is gradually making less-effective

pure water purification techniques obsolete.

Sae te a oe; beeft froower ru costs a reuceateace

• No polishing pack needed for purewater production.

• No need for an anti-scaling cartridgeupstream of the Elix module.

• No extra softeners required.

Peace of , ease of use

• Consistent water quality.• High resistance to scaling ensures

high Elix module reliability.• Designed to provide pure water for

compliance with industry standards.• No reliance on third parties to supply

regenerated ion-exchange resins.

Paet-fre, cea tecoo

• Safe and clean technology.• Minimal use of disposable purificatio

cartridges limits waste.• Low electricity consumption.• No need for the strong bases and

acids used to regenerate resins orclean still boilers.

• No additional transportation/spacerequired for shipping and storingresin cartridges or bottled water, et

PROVIDING CONSISTENTLY PURE WATERADVANCED ELIX TECHNOLOGYTe E Aatae sste prouces watertat eets te est staars aesures cosstet quat.

Following a reverse osmosis step, the Millipore-patented E tecoo boosts the purificationprocess to produce consistent, superior qualitypurified water.

- Millipore’s Elix module consists of an anode and acathode separated by alternating ao-pereabea cato-pereabe ebraes.

- The compartments used for ion removal are filledwith quat o-ecae res that ispermanently and gently regenerated by a weakelectric current, eliminating the need for chemicalregeneration on-site, as well as the exchange of DIresin cartridges.

- Actate carbo beas fill the cathodecompartment to ensure dispersion of the hydroxylions generated over a large volume, preventing thehigh pH that would lead to CaCO

3precipitation. This

patented technology eliminates the need to protectthe Elix module by a softener. Time in operation

P r o d u c t w a t e r r e s i s t i v i t y

Elixwater quality

Standarddeionizationwaterquality

E tecoo s.repaceabe o-ecae ress

The graph below clearly shows how Elix technology outdistances

competitors’ systems that use ion-exchange resins which must bechemically regenerated on-site or exchanged.Unlike these systems, which risk variations in water quality as theresins are gradually exhausted, Elix Advantage systems produceconsistently high quality pure water. You can be sure at all times of thequality of the pure water produced by your Elix Advantage system.

Parameter Value

Resstt> 5 MΩ·cm* @ 25 °C,typically 10 to 15 MΩ·cm @ 25 °C

Couctt< 0.2 µS/cm* @ 25 °C,typically 0.067 to 0.1 µS/cm @ 25

TOC t yp ic ally < 3 0 ppb

Bactera cout < 1 cfu/ml

* [CO2 ] ≤ 30 ppm in feed water



INSIDE THE ELIXADVANTAGE

SYSTEM

COMPLEMENTARYPURIFICATION STEPSThe purification sequence for the new Elix Advantage system is basedon purification steps that complement one another and optimize thebenefits of each technology.

Proar Pretreatet Pack

• TheProgard pretreatment pack containsactivated carbon, anti-scaling compoundsand a prefilterto efficiently protect theROmembrane against oxidation, scaling andplugging.

• Silver-impregnated activated carbonpreventsproliferation of thebacteriapresent in tap water.

• RFID (Radio Frequency IdentificationTechnology)detection eliminatestherisk of errorssuch as incorrect pack installation orpack exhaustion, etc.

Pretreatet Beefts

• Pretreatment with a Progard pretreatmentpack providesthebest protection forthesystem’sReverse Osmosis(RO)membrane,guarding it against clogging and helping toextend equipment lifetime.

• In addition, becausepack changesaretriggered in part by actualwaterconsumption, you obtain optimaluse fromyourpretreatment, aswellas two extrabenefits: controlled budget expensesforyou—and lesswaste forthe environment.

Poetee reserors uarateete purt of our store water

• Purewater requiresa storagesystemthat preventsdegradation of yourwatequality. Millipore’sreservoirs aredesignto maintain consistent purity of storedwaterand provideeffective protectionagainst airbornecontaminants.

- Optimized design and material - Cylindricalshape - Polyethylenestructure - Fully drainable - Opaquereservoir walls - Advanced vent filterfor

increased protection - OptionalAutomatic Sanitization

Module(ASM) and watersensor

Autoatc recrcuato

• At regularintervals, thestored purifiedwateris recirculated and sanitized by aUV lamp in orderto ensurethat storedwaterbacterial levelsremain very low.

Optu water quat atte pot-of-use

• Beforedelivery, purewaterfromtheElAdvantagesystemis again sanitized bya UV lamp and then filtered through a0.22µm finalfilt erat thedispensing poThisreduces thebacterial count to lessthan 1cfu/ml to provideoptimumwaterquality forbacteria-sensitive applicatio

Custoze, febe water eera quat

• Simpleand intuitivewater deliveryadapted to yourneeds

- Ergonomic and practicalE-POD desig - Different configurationsto fit your

laboratory environment (up to threeE-POD unitsper system)

- Choiceof automatic ormanual watedispensing modes

- Finalfilters to match specificapplications

• Optimized design: An integralpart of thpurewater recirculation loop, theE-POdispenserhasno dead-legs in which wacan stagnate, thusavoiding bacterialcontamination.

iforato at a ace for cotro a acttes

• Allthe information you need forregularuseis visibleon theE-POD waterdispenserscreen, including:

- Waterquality data - Systemstatus - Tank level - Maintenancemessages - Waterdispensing information

• High waterrecovery: Part of theRO rejectwateris recycled back to theROmembranefeed waterstream. Waterrecovery canbeadjusted up to 50% to optimizewaterconsumption, depending on the feed waterquality and thepretreatment sequenceused.

• Constant product flow rate: StandardRO-based systemstypically undergotemperaturevariations. Forexample, afeed watertemperature decreaseof 1°Cdecreasesthepermeateflow rateby 3 %,creating therisk of watershortages duringthewinter. In ElixAdvantagesystems, thepump pressureincreases when thefeedwatertemperature decreasesin ordertomaintain a steady product flow rate.

E eectroeozato beefts

• Consistent high quality water.

• Minimalelectricit y consumption: theElix moduleuses theequivalent of theenergy required by an electric light bulb.

• Uninterrupted waterproduction- Continuously regenerated ion-exchangeresins eliminate

hazardouschemicalr egeneration orcostly resinreplacement.

• Best quality resins- High-gradequality resinsused in moduledesign.- Resinsdo not degrade, asthey are not exposed to harsh

regeneration chemicalsor removed fromthe system.

Optu ow bactera ees at a staes

• Thelast purification step consistsof sanitizing thepurewater using a powerful254nm UV lamp, which hasa well-knownbactericidaleffect.

UVSANITIzATION

DURINGwATER

PRODUCTION

ater

olenoidValve

dPack

re Regulator

ationPort

ater ConductivityCell

tridge

Water RecoveryLoop

Valve

ryTubing

olenoid Valve

ate ConductivityCell

te Divert Valve

dule

t ResistivityCell

unit withfinal filter

p

t water

oir withASM

19

21

5

20

1

2

3

4

5

6

7

8

13

14

15

18

16

MAINTAININGTHE qUALITy

OF STOREDwATER

i orer to esurete best quat

for store water,mpore as

carefu seectete ateras use

to aufactureour storaereserors.

E-PODUNITS FOR

CUSTOMIzEDPURE wATER

DELIVERy

ELIX MODULE

i te trpurfcato step,

mpore’s pateteE oue uses

eectroeozatoto reoe te

rea os. (Forfu etas, pease

see pae 6.)

ADVANCEDREVERSEOSMOSIS

Reerse Ososs (RO),te seco purfcato

step, reoes95-99 % of os a99 % of a ssoeoracs (mW > 200

dato), croorassa partces.

PRETREATMENT

te frst purfcatostep, a a--oe

pretreatet packfcet reoes teartces, free core coos preset

potabe tap water.

9

10

But- aace features for 2 ajor beefts:

11

12

17

12



dfferet ees of foratofactate sste use

The Elix Advantage system offers threelevels of information, making it easyfor users to access data quickly andefficiently for:

• Daily use: All necessary information isvisible on the E-POD screen.

• Maintenance use: Information isvisible on the main screen of thewater production unit. Step-by-stepdirections and diagrams indicate theactions to be performed.

• System management: Criticalparameters, such as set points,are protected by an ID login and apassword in the production unit’s“Manager” menu.

Optze cotro of water quat

After each purification step, the Elix

Advantage system checks the relevantparameters:

• Feed pressure and feed water quality

• RO pressure, RO water quality, ROmembrane efficiency (% ion rejection)

• Elix Advantage system water qualityand temperature

If an anomaly occurs, you will be alertedby a message on the E-POD and waterproduction unit screens and/or a warningbuzzer.

Best--cass otor

The reliability of the resistivity

measurement displayed by the ElixAdvantage system is ensured by:

• Low cell constant (0.01 cm-1) and theflow-through design of the resistivitycell

• Temperature measurement with a 0.1degree increment

• The possibility to perform theresistivity suitability test as requiredby USP <645>

KEEP IT ALLUNDER CONTROL

SySTEm FEATURES ThAT lET yOU

Instant Water Quality report can be printed from the E-POD unit.

Autoatc cotro aateace

The system’s reverse osmosis membraneis kept in optimum operating condition byself-maintenance functions that ensureoptimal water quality:

• Automatic flush mode: cleans the ROmembrane surface with a high waterflow.

• Automatic rinsing mode: RO permeateis diverted to drain until the qualitymeets expectations.

• Automatic cleaning cycle: sanitizationof the RO membrane (cleaningfrequency can be adjusted according tolocal feed water quality).

Rsk aaeet

Millipore offers an optional water sensor.

This water detection feature protectsyour lab from water damage by isolatingthe system from the main line, should aleak occur.

Traceabt a reote access

To facilitate your daily work in a GLP and

GMP (Good Manufacturing Practices)environment, all quality and events-related data is available. The user canaccess this data via PC for on-screenconsultation. Data can also be directlyprinted out from a printer connected tothe E-POD unit.

Important user information,such as water quality or systemstatus can be seen at a glanceon the E-POD units’ multicolor graphic display.

Data on systemoperation and performance appearson the production unit’smain graphic display.

A QuickReferenceGuide islocated insidethe door.

System history reports can bedownloaded to

a computer forstorage or to printout a hard copy.



Quafcato epertse

Facilitates laboratory validation procedures- With more than 10 years’ experience in water

system qualification services, Millipore canassist you in complying with regulatorystandards applicable to your industry.

- Validation support is provided by trainedMillipore Field Service Support Engineersusing calibrated equipment and QualificationWorkbooks.

Copreese Serce Prora

Covers your requirements every step of the way- Installation- Technical and scientific assistance- Preventive maintenance visits- Troubleshooting visits- Customized user training- Verification and/or calibration of monitoring devices- Pharmacopeia suitability tests- Validation support- Maintenance plans

Quat isurace

- Certificate of Conformity – The product has been assembled and tested according to Millipore’s stringentQuality Assurance procedures.

- Certificate of Calibration – Included for the built-in resistivity meter- Declaration of Conformity – (European Union EC Directive)- Certificate of Quality – Included for all system consumables- POD Pak validation – POD Paks are validated for efficient removal of the specific contaminants that they

target.- ISO 90001 v. 2000 and ISO 14001-registered manufacturing site – Certificates are available upon request.- CE, cUL, FCC – To ensure efficiency and safety of operation, the Elix Advantage system is certified for

safety and electromagnetic compatibility.

Carefree operato

The Elix Advantage system provides informationon replacement of consumables at 15 days’notice, ensuring that you have enough time toobtain the required products.Thanks to the system’s innovative RFIDtechnology, catalogue and serial numbersfor Progard consumables are automaticallyregistered in memory upon insertion, whichensures optimal traceability and also preventsinsertion of an incorrect consumable.

Additionally, the system is able to manage itsown service agenda. If you request this option,you will receive a warning 30 days in advanceprompting you to schedule a maintenanceservice visit.

ALL THE

CONFIDENCEYOU NEED

PROviding



Oter cofuratos of te ew E sste are aaabeto proe pure water for atoa ees, cu use eroeta cabers, weateroeters, cca cestraazers, assware was aces or autocaes, etc.

To meet these specific needs, various options are available, such as:

• Distribution of pressurized water to feed laboratory equipment• Compatibility with larger size reservoirs (200-and 350-liter capacity)• Additional in-line water polisher (E-Gard™ cartridge)

ALL THEVERSATILITYYOU NEED

AddiTiOnAl SySTEm COnFigURATiOnS FOR

LONG-TERMSUSTAINABILITYAt mpore, we wat to esure tat our proucts respectte eroet. Te ew E Aatae sste as beeese to refect our ecato to cea tecoo apure processes.

• Tap water savings thanks to the system’s high water recovery.• Reduced electricity consumption: Elix Advantage systems use up to

200 times less energy than conventional distillation equipment.• Manufacturing process designed to respect the environment:

our manufacturing facility is certified to ISO 14001, a voluntary

environmental standard.

WATER SPECIFICATIONSE water (at Elix module outlet)

Parameter Value

Resstt > 5 Ω·Mcm @ 25 °C

TOC < 30 ppb

If pure water is sourced from an E-POD unit, the following water qualityspecications are achieved :

Parameter Value

Bactera < 1 cfu/ml*

Partcuates > 0.22 µm < 1 par ticulates /ml*

Proes (endotoxins) < 0.0 01 EU/ml**

Rnases < 0.01 ng/ml**

dnases < 4 pg/µl**

With Millipak® lter with Millipore Express® membrane or Biopak® ultralter as POD Pak** With Biopak ultralter as POD Pak

The Elix Advantage system is designed to meet or exceed requirementsas described by ISO 3696 (Grade 2 water); ASTM D1193 (Type II resistiviand TOC Table I specications); and by the United States, European and

Japanese Pharmacopeias for Puried Water.

WATER DELIVERY

SstemPure aterproduction(Max l/da)

Pure aterdeliver at E-PO(l/min)

E Aatae 3 70 Up to 2.0






Lit. No. PB1221EN00 Printed in France 10/08. © Copyright 2008, Millipore Corporation, Billerica, MA, U.S.A. Millipore, Milli-Q, Elix, E-POD, Millipore Express, Biopak andProgard are registered trademarks of Millipore Corporation. E-Gard, the “M” mark and Advancing Life Science Together are trademarks of Millipore Corporation. ASTM

is a registered trademark of the American Society for Testing and Materials. ISO is a registered trademark of the International Organization for Standardization. Allrights reserved.

Photographs: BHL Productions. Design: Sysaxe.

mpore offers ore oate tecooesa stroer appcato support to streaeprocesses a proe cosstet reaberesuts. Our lab Water eperts take te te toeauate te ees of ua abs a partcuarappcatos orer to recoe a sste tatbaaces water quat wt oue a strbutorequreets, reo water quat cocers socustoers ca focus o ter researc.

.millipore.com/ofces

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