LINEALIDAD DIGOXINA 20µgmL

7/23/2019 LINEALIDAD DIGOXINA 20µgmL

http://slidepdf.com/reader/full/linealidad-digoxina-20gml 1/118

NValores de x Valores de y

1 24 613.1823

2 24 614.79

3 24 615.2457

4 32 822.84

5 32 819.03

6 32 822.54

7 40 1025.2312

8 40 1023.5695

9 40 1021.1386

10 48 1232.24

11 48 1230.18

12 48 1231.913 56 1437.81

14 56 1440.5

15 56 1437.281

n 15

n-2 13n-3 12

ro!ed"o x 40.000

ro!ed"o y 1025.8318866667

#x 600#y 15387.4783

#x$2 25920.000 %xx#y$2 17055902.361 %yy#xy 664896.380 %xy#e$2 &%%E' 5.72414E+01

M%E 4.40318E+00

end"en(e 2)573E*01In(er+e,(o -3)277E*00

2)098E*00

0)0815608696

&#'$2&#.'$2

Des/"a+"on es(andarres"dal &!odelol"neal'

Des/"a+"n es(ndardel ,ro+eso sxo



0)20

Valores de x Valores de y24.000 613.182

24.000 614.790

24.000 615.246

32.000 822.840

32.000 819.030

32.000 1493.300

40.000 1025.231

40.000 1023.570

40.000 1021.13948.000 1232.240

48.000 1230.180

48.000 1231.900

56.000 1437.810

56.000 1440.500

56.000 1437.281

n 15

n-2 13

n-3 12ro!ed"o x 40.000

ro!ed"o y 1070.549

#x 600 &#x'$2#y 16058.2383 &#y'$2#x$2 25920.00 %xx#x$3 1190400.000 %xy#x$4 57249792.000

#xy 686360.700 %x$4#x$2y 31229417.18 %x$2y

18609275.1992564

+ -2.42467E-01

42.3302392857

a -203.6778228572

s$2y 33188.7131646502

sy 182)1776966718

Des/"a+"on es(andarrela("/a del ,ro+esoDE sxo &'

%x$3

#y$2



D%$2 -398207.316595299

+ -11.998

(alas 9.330

2) DE%VIAIO

N Valores de x Valores de y1 24.000 613.182

2 24.000 614.790

3 24.000 615.246

4 32.000 822.840

5 32.000 819.030

6 32.000 822.540

7 40.000 1025.231

8 40 1023.5695

9 40 1021.138610 48 1232.24

11 48 1230.18

12 48 1231.9

13 56 1437.81

14 56 1440.5

15 56 1437.281

Valor ,ro!ed"o : Des/"a+"n es(ndarDE : &'

Calculo

2.29332E-03

s1 4.78887E-02

(+ 537)241( &0;05;13' 2)1604

L"!"(e s,er"or 2)5831E*01L"!(e "n:er"or 2)5624E*01I 1)035E-01

3.96E+00

s0 1.99E+00

ONL%ION+al+lado < (ala

s1$2

s0$2



(+ 1.6464

(&0;05>13' 2)1604

L"!"(e s,er"or 1)023L"!"(e "n:er"or -7)578

I 4)3006

al+lo

%% 1270879.22394455

r$2 1)0000 oe?+"en(e de de(err 1)0000 oe?+"en(e de +orrel

537)2405( (alas &0;05>13' 2)1604

N Valores de x Valores de y1 24 613.1823

2 24 614.79

3 24 615.2457

4 32 822.84

5 32 819.03

6 32 822.54

7 40 1025.2312

8 40 1023.5695

9 40 1021.1386

10 48 1232.2411 48 1230.18

12 48 1231.9

13 56 1437.81

14 56 1440.5

15 56 1437.281

Var !" 0.0043825195

G(+G De"do a He G(+GC11

/alor de +ero



Var in 0.0005293403

+ 8.28

# 5

$ 2

% 0.05

(alas 202

Var !" 0.0043825195

&var 0.0105498344

K+ 0)4154# 5

$ 2

% 0.05

K(alas 0)6838

n 15

a 3

' 5

0.0021099669

lo()p*2 -2.6757243598

&lo()*2 -27.848470346

, 1.0912267482

2+ 2)51272 0;05> 4 9)4877


2 24 614.79

3 24 615.2457

4 32 822.84

5 32 819.03

6 32 822.54

7 40 1025.2312

8 40 1023.5695

9 40 1021.1386

10 48 1232.24

11 48 1230.18

12 48 1231.9

13 56 1437.81

14 56 1440.5

)p*2



15 56 1437.281

1025.8318866667


2 24 614.79

3 24 615.2457

4 32 822.84

5 32 819.03

6 32 822.54

7 40 1025.2312

8 40 1023.5695

9 40 1021.1386

10 48 1232.24

11 48 1230.18

12 48 1231.9

13 56 1437.8114 56 1440.5

15 56 1437.281

Los /a

60 70 800.00

2.00

4.00

6.00

8.00

10.00

12.00Kr?+o de los es"dos +

e=



%!a de +adradoseres"n 1.271E+06

es"do 5.724E+01

&al(a de a=s(e' 2.904E+01

&Error ro' 2.820E+01

o(al 1.271E+06


2 24 614.79

3 24 615.2457

4 32 822.84

5 32 819.03

6 32 822.547 40 1025.2312

8 40 1023.5695

9 40 1021.1386

1 48 1232.24

11 48 1230.18

12 48 1231.9

13 250 1437.81

14 280 1440.5

15 250 1437.281

Re!"a de Re

DATOS D* +A CURVA D* C,%"e!e."o /(0Pe%d$e%"e /(10Des$a!$o% es"a%dar res$dal /odelo l$%eal0Des$a!$% es"%dar del .ro!eso sxo

Des$a!$o% es"a%dar rela"$a del .ro!eso D*R sxo /0

COP,

1:; Pre(a de a!

en(e de/ar"a+"n



-11.998

S$ !al /3<190 > /9<330 "a(las el odelo

2)- Des/"a+"n es(andar rela("/a d

Valor .roed$o @

Des$a!$% es"%darD*R @ /0

3:; Pre(a de er$@$!a!$o% de la .e%d$e%"e o de la l$Var"ana de la ,end"en(e

Des/"a+"on es(andar de la ,end"en(e25)624 P 1 P

Pre(a "" !al!lado

" "a(las /<5=130

4:; Pre(a de er$@$!a!$B% de la ar$a(le $%de.e%d$e%"e o de .ro.or!$o%al$Var"ana del "n(er+e,(oDes/"a+"on es(andar de la ,end"en(e

-7)578 P 0 Prea (

" !al!lado" "a(las /<5=130

5; S.es"o de oo#e%e$dadValor +al+lado Valor (alas

rea ar(ley 8.28 202

rea de o+@ran 0.4154 0.6838

rea de ar(le(( 2.5127 9.4877

Co%!ls$%& +a D*R P 2;0) Ind"+a l"neal"dad

Co%!ls$o%& Cumple ya que tc (113,256) > (2,1604) ttblas. El !te"#al$ %e c$!el ce"$

Co%!ls$o%es& Cumple c$! la p"ueba t %e tu%e!t %e la #a"able !%epe!%e!te(2,1604)ttablas. Este !te"#al$ !cluye el ce"$.



N -s+ore1 -1.5E*01 -1.834

2 -1.2E*01 -1.282

3 -1.1E*01 -0.967

4 -7.2E*00 -0.728

5 -6.0E*00 -0.524

6 -6.0E*00 -0.341

7 -5.5E*00 -0.168

8 -1.5E*00 0.000

9 1.8E*00 0.168

10 5.0E*00 0.341

11 8.0E*00 0.524

12 1.1E*01 0.728

13 1.1E*01 0.967

14 1.2E*01 1.282

15 1.7E*01 1.834

OIA EL KAIO

7)- Anl"s"s

oe?+"en(e de de(er!"na+"on r$2oe?+"en(e de +orrela+"n

rea de @",(es"s ,ara el +oe?+0 r / 0 " no e)tan a)ociado) no e"i)t

1 r 0 " e)tan a)ociado) e"i)te corr

( (alas &0;05>13'

e%"e de ar$a!$% Sa de !adradosRe#res$% 1.27E*06

da(os eordenados

G(+G

De"do a He G(+GC113;2558 (0;05> 13re+@aada a J C 0;05) El +oe:"+"en(e de

la ,end"en(e 1 ("ene /alor de +ero



Res$do 5.72E*01

/al"a de a?s"e0 2.90E*01

/*rror Pro0 2.82E*01

To"al 1.27E*06



MODELO LINEALx$2 y$2 xQy

576.000 375992.533 14716.375

576.000 377966.744 14754.960

576.000 378527.271 14765.897

1024.000 677065.666 26330.880

1024.000 670810.141 26208.960

1024.000 676572.052 26321.280

1600.000 1051099.013 41009.248

1600.000 1047694.521 40942.780

1600.000 1042724.040 40845.544

2304.000 1518415.418 59147.520

2304.000 1513342.832 59048.640

2304.000 1517577.610 59131.2003136.000 2067297.596 80517.360

3136.000 2075040.250 80668.000

3136.000 2065776.673 80487.736

360000236774488.432971

1920

1270936.46532504

49397.2480000003



x$2 x$3 x$4576.00 13824.000 331776.000

576.00 13824.000 331776.000

576.00 13824.000 331776.000

1024.00 32768.000 1048576.000

1024.00 32768.000 1048576.000

1024.00 32768.000 1048576.000

1600.00 64000.000 2560000.000

1600.00 64000.000 2560000.000

1600.00 64000.000 2560000.0002304.00 110592.000 5308416.000

2304.00 110592.000 5308416.000

2304.00 110592.000 5308416.000

3136.00 175616.000 9834496.000

3136.00 175616.000 9834496.000

3136.00 175616.000 9834496.000

360000

257867017.299587

1920

44031.1680000001

153600

12460032

3480781.4016

E% DE LINEALIDAD1' rea de Mandel



E%ANDA ELAIVA DE LO% AOE% E%E%A

: &yRx'25.54926

25.61625

25.63524

25.71375

25.59469

25.70438

25.63078

25.58924

25.5284725.67167

25.62875

25.66458

25.67518

25.72321

25.66573

25)639410)05739

0)224

e la varianza de la pendiente

al+lo ,ara ,rea de ,ro,or+"onal"dad

; el !odelo se a=s(a a na +al"ra+"on l"neal

0B 1 C0 1B 1 F 0

%" l(+l ((a se re+@aa la @",o(es"s nla +on J C

0B 0 C0 1B 0F0



El "n(er/alo de +on?ana d

e los /alores de +oe?+"en(e de de(er!"na+"on y +oe?+"en(e de +orrel

"na+"on+"on

rea de @",(es"s ,ara el +oe?+"en(e de +orrela+"n

0 B r C 0 &x y y no es(an aso+"ados; no ex"s(e +orrela+"n'

ANALI%I% DE ANOVA

rea de @o!oene"dad de las /ar"anas

: VA S25.5493

0.0020399252 225.6163

25.6352

25.7138

0.0043825195 225.5947

25.7044

25.6308

0.0026479059 225.5892

25.5285

25.67170.0005293403 225.6288

25.6646

25.6752

0.0009501436 225.7232

25.6657

rea de ar(ley

%" l(+l < ((alas se a+e,(a

1 B r F 0 &x y y es(an aso+"ados; ex"s(e +orrela+"n'

3;2558 (0;05> 13 C 2;1604; la 0 es re+@aada a J C 0;05) El +oe:"+



0 B Las /ar"anas son "ales)1B lo an(er"or no es +"er(o al !enos ,ar

+ < (alas se a+e,(a la @",o(es"s nla

rea de o+@ran

K+ < K(alas se a+e,(a la @",(es"s nla

rea de ar(le((

Kr?+os de los res"dales

y$ e y,ro )=614.19 -1.01

6.144E+02614.19 0.60

614.19 1.06

820.01 2.83

8.215E+02820.01 -0.98

820.01 2.53

1025.83 -0.60

1.023E+031025.83 -2.26

1025.83 -4.69

1231.65 0.59

1.231E+031231.65 -1.47

1231.65 0.25

1437.48 0.33

1.439E+031437.48 3.02

2+< 2 (alas se a+e,(a la @",(es"s nla



1437.48 -0.19

#&y-y,ro!'$2

INEVALO% DE ONIANA DE LA EKE%

y$ LI%8.80637E-01 614.1881533 616.2155

8.80637E-01 614.1881533 616.2155

8.80637E-01 614.1881533 616.2155

4.40318E-01 820.0100200 821.4436

4.40318E-01 820.0100200 821.4436

4.40318E-01 820.0100200 821.4436

2.93546E-01 1025.8318867 1027.0024

2.93546E-01 1025.8318867 1027.0024

2.93546E-01 1025.8318867 1027.0024

4.40318E-01 1231.6537533 1233.0873

4.40318E-01 1231.6537533 1233.0873

4.40318E-01 1231.6537533 1233.0873

8.80637E-01 1437.4756200 1439.50308.80637E-01 1437.4756200 1439.5030

8.80637E-01 1437.4756200 1439.5030

ANALI

%y-

lores de y deen es(ar den(ro del "n(er/alo de +on?ana de 95

90 100 110 120

n(ra la /ar"ale de reres"n

n+en(ra+"n



Krados de L"er(ad Med"a de +adrados +1 1.27E+06

288627.3813 4.40E+00

3 9.68E+003.433

10 2.82E+00

14

CUADROS Y DATOS

e a!"or @ /yx0 Var-1.0059E*00 2.555E*01

2.03993E-036.0185E-01 2.562E*01

1.0575E*00 2.564E*01

2.8300E*00 2.571E*01

4.38252E-03-9.8002E-01 2.559E*01

2.5300E*00 2.570E*01-6.0069E-01 2.563E*01

2.64791E-03-2.2624E*00 2.559E*01

-4.6933E*00 2.553E*01

5.8625E-01 2.567E*01

5.29340E-04-1.4738E*00 2.563E*01

2.4625E-01 2.566E*01

3.3438E-01 5.751E*00

1.22227E-013.0244E*00 5.145E*00

-1.9462E-01 5.749E*00

#res$o%& y ' ( )(1x

+,-RAC,ON-3.277E*00

2.573E*01

2.098E*00

8.156E-02

2.039E-01

R RA,CO D* +A R*R*S,ON +,N*A+

VA+,DAC,ON D*+ OD*+O

del <1= 1= %;3



9.330

e a?s"a a % odelo l$%eal:

los :a+(ores res,es(a

25.63941

0.05739

0.224

eal$dad0)0020)048

25)831

537:2412:164

ad3)9631)9911)023

1)64642)1604

de las ar$a%asond"+"n on+ls"n

ooceda)ticidad

ooceda)ticidad

2c 2 tala) % / 005 ooceda)ticidad

6.- Analisis Gráfico de los Residuales

a!'a %e la pe!%e!te !$ !cluye

a que tcal (1,2725)

c tala) % / 005

c tala) % / 005



ráfico de Probabilidad Normal de los residuos

E OAILIDAD NOMAL . LO% DO% KAIO% DE LO% E%I

on los +oe?+"en(es de de(er!"na+"n y +orrela+"n

1.0000

1.0000

"en(e de +orrela+"ne correlacin

lacin

537.2405

2.1604

ANALISIS DE ANOVA

rados de +$(er"ad ed$a de !adrados !1 1.271E*06

C 2;1604; la 0 esorrela+"on no es +ero; n"

-2.0E+01 -1.5E+01 -1.0E+01 -5.0E+00 0.0E+00

-2.500

-2.000

-1.500

-1.000

-0.500

0.000

0.500

1.000

1.500

2.000

2.500

Kr2?+o de ro3a3"l"dad Nor!a

DA4O% O5DE

D;s!ore



13 4.403E*00 288627.384

3 9.681E*00

3.43310 2.820E*00

14



y$ e e$2 &%%E'

614.188 -1.006 1.012

614.188 0.602 0.362

614.188 1.058 1.118

820.010 2.830 8.009

820.010 -0.980 0.960

820.010 2.530 6.401

1025.832 -0.601 0.361

1025.832 -2.262 5.118

1025.832 -4.693 22.027

1231.654 0.586 0.344

1231.654 -1.474 2.172

1231.654 0.246 0.0611437.476 0.334 0.112

1437.476 3.024 9.147

1437.476 -0.195 0.038



y$2 xy x$2y375992.5330333 14716.375 353193.00

377966.7441 14754.960 354119.04

378527.2713685 14765.897 354381.52

677065.6656 26330.880 842588.16

670810.1409 26208.960 838686.72

2229944.89 47785.600 1529139.20

1051099.013453 41009.248 1640369.92

1047694.52133 40942.780 1637711.20

1042724.04041 40845.544 1633821.761518415.4176 59147.520 2839080.96

1513342.8324 59048.640 2834334.72

1517577.61 59131.200 2838297.60

2067297.5961 80517.360 4508972.16

2075040.25 80668.000 4517408.00

2065776.672961 80487.736 4507313.22



%"

DE : P 2;0

0;05) La ,end"en(e es d":eren(e de +ero



e "n+l"r el +ero

a+"on

&S'Qs$2 los$2 &S'Qlo$2

0.0040798503 -2.6903857663 -5.38077153

0.0087650391 -2.3582761397 -4.71655228

0.0052958118 -2.5770974558 -5.15419491

0.0010586806 -3.2762650591 -6.55253012

0.0019002872 -3.0222107521 -6.0444215

la @",(es"s nla

Valor re+o!endale rT 0;999

"en(e de +orrela+"on no es +ero; n" la ,end"en(e es 1 ("ene



na de las /ar"anas

&y-y,ro )='$21.497E+00

1.475E-01

7.051E-01

1.877E+00

5.954E+00

1.145E+00

3.679E+00

6.574E-02

4.728E+00

6.400E-01

1.588E+00

2.116E-01

5.189E-01

3.880E+00



1.561E+00

2.81972E+01

N %IMLE

LII612.16081

612.16081

612.16081

818.57648

818.57648

818.57648

1024.66140

1024.66140

1024.66140

1230.22021

1230.22021

1230.22021

1435.448281435.44828

1435.44828

%I% DE ANOVA

&LII P y P LI%'; en +aso +on(rar"o se +ons"dera n /alor aerra

500.00 600.00 700.00 800.00 900.00 1000.00 1100.00 1200.0

-6.00

-5.00

-4.00

-3.00

-2.00

-1.00

0.00

1.00

2.00

3.004.00

Kr?+o de los es"dos +on(ra los /alo

Valores es("!ados de y

e=

150 170 1900.5

1.5

2.5

3.5

4.5

5.5

6.5

7.5

8.5

9.5

10.5 L"neal

%eUal Anal"("+a



(alas

4.6672

3.708

PASAR



O%

"a(lason+ls"ones

:i ;c1 < ; tala) )e conclue ,ue la

5.0E+00 1.0E+01 1.5E+01 2.0E+01

l de los res"d0os

ADO%



4.6672

3.708

pendiente e) di$erente de cero

:i ;c2 ; tala) el odelo )e a=)utaadecuadaente a lo) dato)



(e

1300.00 1400.00 1500.00

es a=s(ados

210 230 250 270 290 310

dad del %"s(e!a

on+en(ra+"on



*EACT,

N 9F 3

% 3 1

Pe%d$e%"e (1 2.573E*01 ro!ed"o y,%"er!e."o ( -3.277E*00 sxx

N N$el de !o%!e%"ra!$% /0

1 80

2 803 80

4 100

5 100

6 100

7 120

8 120

9 120

R*+A D* GAP*+

ed$a%a Re!.erado 65.146

N Des$a!$o%es a(sol"as de la ed$a%a Noral$adas a(sol"as1 0.1179 0.144

2 0.9024 1.105

3 0.2199 0.269

4 0.7312 0.895

5 0.1083 0.133

6 0.7497 0.918

7 0.5506 0.674

*l Re!.erado de(e es"ar 98< ;12<



8 0.0000 0.000

9 1.2956 1.587

ed$a%a A-S 0.551

AD 0.817

S$ alor %oral$ado H 3<5 se !o%s$dera alor a(erra%"eonls"onB No @ay /alores aerran(es

F 3 SN 9

PrePre(as Valor !al!lado Valor "a(las

ar(ley 2.33 87.50

o+@ran 0.4900.8709

ar(le(( 0.3635 5.9915

#Slos$2 -1)43858s,$2 0)61171los,$2 -0)2134556139&n-'los,$2 -1)2807336832H 0)157850939

rea ( de s(den(s

Valor +al+lado (

96)7304

$2 .$26400.000 2726.016

6400.000 2641.448

6400.000 2734.546

10000.000 4339.838

10000.000 4229.927

10000.000 4146.917

14400.000 6008.528



14400.000 6111.403

14400.000 6356.906

n 9

n-2 7

ro!ed"o x 100.0ro!ed"o y 65.18

#x 900.0

#y 586.63

#x$2 92400.000 %xx#y$2 39295.529 %yy#xy 60253.567 %xy#e$2 &%%E' 4.2104

M%E 0.6014889496

#&x-x,ro'$2

DAO% DE LA LINEALIDAD DEL ME

,%"e!e."o /(0Pe%d$e%"e /(10Des$a!$o% es"a%dar res$dal /odelo l$%eal0Des$a!$% es"%dar del .ro!eso sxoDes$a!$o% es"a%dar rela"$a del .ro!eso D*R sxo /0

VALIDAION DEL MODE

1: Des$a!$o% es"a%dar rela"$a de los @a!"ores res.es"Valor .roed$o @ Des$a!$% es"%darD*R @ /0

2:; Pre(a de er$@$!a!$o% de la .e%d$e%"e o de la l$%eal$daVar"ana de la ,end"en(e

Des/"a+"on es(andar de la ,end"en(e0)6252 P 1 P

La ,end"en(e dee "n+l"r el /alor de no) NO ex"s(e e:e+(

Pre(a "" !al!lado

" "a(las /<5=70

&#'$2&#.'$2

Co%!ls$%& +a D*R P 2;0) Ind"+a l"neal"dad



3:; Pre(a de er$@$!a!$B% de la ar$a(le $%de.e%d$e%"e o de .ro.or!$o%al$dadVar"ana del "n(er+e,(oDes/"a+"on es(andar del "n(er+,(o

-4)879 P 0 P

El "n(er/alo de +on?ana de la ,end"en(e "n+lye el /alor +ero) No ex"s(e sesorea (

" !al!lado" "a(las /<5=70

oe?+"en(e de de(er!"na+"on r$2oe?+"en(e de +orrela+"n

rea de @",(es"s ,ara el +oe?+"en(e de0 r / 0 " no e)tan a)ociado) no e"i)te correlacin

1 r 0 " e)tan a)ociado) e"i)te correlacin

( (alas &0;05>7'

N Da"os orde%ados de e1 -1.375

2 -1.173

3 -0.796

4 -0.388

5 -0.214

6 0.424

7 0.5468 1.041

9 1.936

, , .

Co%!ls$o%es& Cumple c$! la p"ueba t %e tu%e!t %e la #a"able !%epe!%e!te ya que tcal (1,1617) !cluye el ce"$.

G(+G

De"do a He G(+GC49;5078 (0;05> 13 C 2;1604; la 0 es re+@+oe?+"en(e de +orrela+"on no es +ero; n" la ,end"en(e 1 ("ene



on+en(ra+"on en+on(rada e80.000 -1.375

80.000 -1.173

80.000 -0.796

100.000 -0.388

100.000 -0.214

100.000 0.424120.000 0.546

120.000 1.041

120.000 1.936

y$ e79.535 -1.3752

79.535 -1.1728

79.535 -0.7962

99.344 -0.3876

99.344 -0.2143

99.344 0.4238

119.152 0.5458

119.152 1.0405

119.152 1.9361



e%"e de ar$a!$% Sa de !adradosRe#res$% 1053.93664

Res$do 4.21042

/al"a de a?s"e0 0.02689

/*rror Pro0 4.18353

To"al 1058.14706

Co%!e%"ra!$% Ad$!$o%ada Co%!e%"ra!$o% e%!o%"rada

80.0 52.2

80.0 51.4

80.0 52.3

100.0 65.9

100.0 65.0100.0 64.4

120.0 77.5

120.0 78.2

120.0 79.7

205.0

225.0

245.0

265.0

KAIO



*EACT,TUD D*+ *T

Concentracion >oinal 200

n on+en(ra+"on No!"nal %eUal anal"("+a1 200 0.8393

2 200 0.8476

3 200 0.8507

4 200 0.8469

5 200 0.8332

6 200 0.8403

El e+,erado dee es(ar 98;0 -102;0) La DE P 2;0

R*+A D* GAP*+

Med"ana 0)080

Nor!al"adas asol(as0.000 0.699

0.000 0.650

0.000 1.154

0.000 0.536

0.000 1.690

0.000 0.536

Med"ana A% 0.000

Des/"a+"ones asol(as de la!ed"ana

125.0 145.0125.0

145.0

165.0

185.0



MAD 0.000

%" /alor nor!al"ado 3;5 se +ons"dera /alor aerran(e

rea ( de s(den(s

Valor +al+lado (+

1546)2997



TUD D*+ *TODO: CASO 1: *TODO P+AC*-O CARADO

1025.8318866667 se 2.0983763046

1920 (&0;05>7' 2.3646

Co%!e%"ra!$% Ad$!$o%ada SeJal a%al$"$!a Co%!e%"ra!$o% e%!o%"rada

80.00 1340.00 52.21

80.00 1319.00 51.4080.00 1342.10 52.29

100.00 1691.60 65.88

100.00 1670.00 65.04

100.00 1653.50 64.40

120.00 1991.00 77.51

120.00 2008.00 78.18

120.00 2048.00 79.73

ro!ed"os

DE %eso

De"er$%a!$o% de Valores A%alos o a(erra%"es

98.148

98.171

98.423

98.971

99.129

99.948

100.101

: +a D*R P 2<

+ ecupe"a%$($"%e!a%$s)



100.384

100.907

PRU*-A D* ,UA+DAD D* +AS VAR,ANIAS

2 % 3

a de $#aldad de las ar$a%asCo%d$!$% Co%!ls$%

c tablas ( / 0,05)

c tablas ( / 0,05)2c 2 tablas ( / 0,05)

PRU*-A " de S"de%"

/alor ( &0;05; 8' on+ls"n

2)3060

ANA+,S,S D* +A +,N*A+,DAD D*+ *TODO

. y$ e4176.901 51.928 0.2835

4111.602 51.928 -0.5327

4183.431 51.928 0.3651

6587.745 65.181 0.6962

6503.789 65.181 -0.1434

6439.656 65.181 -0.7847

9301.764 78.435 -0.9201

l cumpl" las p"uebas s!&ca que las #a"a!'as %e las ts$! equ#ale!tes, es %ec" que el &act$" c$!ce!t"ac! !$ "esulta%$s.

?l )er t c ttala) no e"i)te di$erencia )i(ni@cativedia 100 A por lo ,ue la e"actitud e) correcta.



9381.055 78.435 -0.2593

9567.625 78.435 1.2954

810000.0

344136.44

2400

1058.1470627026

1590.4238228008

ODO

-1.0864

0.6627

0.7756

1.1703

1.1703

O

0.65152

0.00704

1.081

2)506E-04

1)583E-020)700

!a(r")

41:8592:3646



2)573041)6042)707

)

0)67732)3646

0.9960

0.9980

orrela+"n

41.8594

2.3646

Gráfico de Probabilidad Normal de los residuos

-s+ore-1.593

-0.967

-0.589

-0.282

0.000

0.282

0.589

0.967

1.593

(2,3646 )ttablas. Este !te"#al$

aada a J C 0;05) El/alor de +ero

-2.000 -1.500

-s+ore



60.000 70.000 80.000 90.000 100.000 110.000

-2.000

-1.500

-1.000

-0.500

0.000

0.500

1.000

1.500

2.000

2.500

Kr2?+o de los res"d0os +on(ra la /a

8on+en(ra+"1n WDR!L

e=

60.000 70.000 80.000 90.000 100.000 1

-

-1.5000

-1.0000

-0.5000

0.0000

0.5000

1.0000

1.5000

2.0000

2.5000

Kr?+o de los res"dos +on(ra la /ar"a

e?



ANALISIS DE ANOVA

rados de +$(er"ad ed$a de !adrados !1 1053.9366

1752.2137 0.6015

1 0.0269

0.0396 0.6973

8

yKLI

51.9 0.16708 50.96

51.9 0.16708 50.96

51.9 0.16708 50.96

65.2 0.06683 64.57

65.2 0.06683 64.5765.2 0.06683 64.57

78.4 0.16708 77.47

78.4 0.16708 77.47

78.4 0.16708 77.47

%y-

- .

Valores es("!ados de .

E LA EKE%ION DEL MEODO



DO: CASO 2 *TODO P+AC*-O CARADO: CONC*NTRAC

Bnidade) n 6

on+en(ra+"on En+on(rada e+,erado0.1600 0.080

0.1603 0.080

0.1605 0.080

0.1603 0.080

0.1598 0.080

0.1601 0.080

ro!ed"o 0.080s 0.000

DE 0.1583

%eso -99.9199

Da(os ordenados99.649 Pre(a L

100.380X10&M"n'

100.500 X10&May'101.291

101.375 %" X10 X +r"("+o se re101.746

Pre(aK!enorK!ax

X+r" &J C0;05'

165.0 185.0 205.0 225.0 245.0

on+en(ra+"on ad"+"onada



%" K K +r"("+o se re+@a

PRU*-A " de S"de%"

/alor ( &0;05; 5' on+ls"n

2)5706

K+r"("+o &J 0;05; 2+olas'

?l )er t c ttala) no e"i)te di$erencia )i(ni@cativedia 100 A por lo ,ue la e"actitud e) correcta.



se$R1$2 6.652E-03 1RN 1.111E-01

1$2Qsxx 1.271E+06 %% 1053.93664

Re!.erado sx! ,C E! sK2 &S'Qs$2

65.264 0.086 0.203

0.385174 0.7703564.244 0.086 0.20365.366 0.086 0.203

65.877 0.086 0.203

0.551535 1.1030765.038 0.086 0.203

64.397 0.086 0.203

64.596 0.086 0.203

0.898416 1.7968365.146 0.086 0.203

66.442 0.086 0.203

65.152

0.704

1.081

-34.85

Pre(a L de D$xo%

X11 &M"n' 0.010

X11&May' 0.191

0)564%" X11 X +r"("+o se re+@aa el da(o

Pre(a de r((sK!enor 1.2901

K!ax 1.8315

X+r" &J C0;05'



2)215

%" K K +r"("+o se re+@aa el da(o

J :5

e$2 :&yRx' y,ro )= y-y,ro )='$20.0804 0.6526

51.97

0.05996

0.2838 0.6424 0.32646

0.1333 0.6537 0.10660

0.4847 0.6588

65.10

0.59828

0.0206 0.6504 0.00437

0.6158 0.6440 0.50043

0.8466 0.6460 0.91922

K+r"("+o &J 0;05; 2+olas'

es c$!ce!t"ac$!es utl'a%as&luye e! la #a"abl%a% %e l$s

a entre la recuperacion



0.0673 0.6515 78.47 0.08880

1.6781 0.6644 1.57942



-1.000 -0.500 0.000 0.500 1.000 1.500

-1.000

-0.500

0.000

0.500

1.000

1.500

2.000

r2?+o de ro3a3"l"dad Nor!al de lo 5es"d0os



-2.000

-1.500

DA4O% O5DENADO%

120.000 130.000

"a3le de reDres"1n

10.000 120.000 130.000

le de reres"n



"a(lason+ls"ones

5.5914

5.987

L%52.89

52.89

52.89

65.79

65.7965.79

79.40

79.40

79.40

:i ;c1 < ; tala) )e conclue ,ue lapendiente e) di$erente de cero

:i ;c2 ; tala) el odelo )e a=)utaadecuadaente a lo) dato)



ON NO,NA+

de D$xo%

0.349

0.177

0)628@aa el da(o

e r((s785558.5827

802100.2079

265.0



2)020

a el da(o

a entre la recuperacion



los$2

-0.41434 -0.82869

-0.25843 -0.51685

-0.04652 -0.09305

lo()*2



2.000 2.500



ed$!$%SeJal A%al$"$!a

1 518.2126

2 518.4

3 520.02214 520.1538

5 520.9166

6 519.8642

7

8

9

10

Proed$o 519:587s 1:745

D*R :27,C /M0 :769

R*+A D* GAP*+

Med"ana 519.94315

>D

1 1.73055 0.702

2 1.59245 0.646

3 0.07895 0.032

4 0.21065 0.085

5 0.97345 0.395

6 0.07895 0.032

7 519.94315 211.016

Prae"ros dePre!$s$%

Des/"a+"ones asol(as de la!ed"ana Nor!al"adasasol(as



8 519.94315 211.016

9 519.94315 211.016

10 519.94315 211.016

Med"ana A% 1.6615

MAD 2.4640045

S$ alor %oral$ado H 3<5 se !o%s$dera alor a(erra%"e

onls"onB No @ay /alores aerran(es



,DON*,DAD D*+ S,ST*A

Pare"ros Cra"o#r@$!os

Neros de Pla"os Ter$!os a!"or de Ca.a!$dad

2.856 0.600 1293 8.83

2.844 0.6 1231 8.82

2.857 0.6 1213 8.92.860 0.614 1215 8.93

2.854 0.617 1197 8.91

2.850 0.618 1227 8.91

2)854 0)6082 1229)3333 8)88330)00572 0)0090 33)4046 0)0463

0)20040 1)4868 2)7173 0)52160)00409 0)0065 23)8962 0)0331

De"er$%a!$o% de Valores A%alos o a(erra%"es

ara n C 10

Pre(a L de D$xo%1673.5 X11 &M"n' 0.000

1673.7 X11&May' 0.000

1673.8 0)5301673.9 %" X11 X +r"("+o se re+@aa el da(o1675

1675.5 Pre(a de r((sK!enor 1.2788

T$e.o de Re"e%!$%/$%0

a!"or de ColaUSP

Da(osordenados

X+r" &J C0;05'



K!ax 1.2377

2)290K+r"("+o &J 0;05; 2+olas' 1)187%" K K +r"("+o se re+@aa el da(o

K+r"("+o &J 0;05; 2+olas'



Resol!$% N10

9

YDIVR0ZYDIVR0Z

YDIVR0ZYDIVR0Z

ara n C 6

Pre(a L de D$xo%X10&M"n' 0.100

X10&May' 0.250

0)628X+r" &J C0;05'%" X11 X +r"("+o se re+@aa elda(o



N 9F 3% 3 1

N N$el de !o%!e%"ra!$% /0 Co%!e%"ra!$% Ad$!$o%ada

1 80 80.0

2 80 80.0

3 80 80.0

4 100 100.0

5 100 100.0

6 100 100.0

7 120 120.0

8 120 120.0

9 120 120.0

n 9 SR*+A D* GAP*+

ed$a%a Re!.erado 65.237


2 0.3770 0.599

3 0.4247 0.674

4 0.3529 0.560

5 0.9453 1.501

6 0.7471 1.186

+a D*R P 2<



7 0.0000 0.000

8 0.0907 0.144

9 1.2049 1.913

ed$a%a A-S 0.425 0.674

AD 0.630 1.000

S$ alor %oral$ado H 3<5 se !o%s$dera alor a(erra%"e

onls"onB No @ay /alores aerran(es

P

N 9F 3% 3 1


1 80 160.0

2 80 160.03 80 160.0

4 100 200.0

5 100 200.0

6 100 200.0

R*+A D* GAP*+ed$a%a Re!.erado 0.088


2 65.1410 103.431

+a D*R P 2<



3 65.1405 103.430

4 65.1569 103.456

5 65.1567 103.456

6 65.1567 103.456

ed$a%a A-S 65.149 103.444

AD 96.616 153.407

S$ alor %oral$ado H 3<5 se !o%s$dera alor a(erra%"eonls"onB No @ay /alores aerran(es

PR*C,S,

DIA

N N$el de !o%!e%"ra!$% /0 8

1 80 80.0

2 80 80.0

3 80 80.0

4 100 100.0

5 100 100.0

6 100 100.07 120 120.0

8 120 120.0

9 120 120.0

DIA


+a D*R P 2<



1 80 80.0

2 80 80.0

3 80 80.0

4 100 100.0

5 100 100.0

6 100 100.07 120 120.0

8 120 120.0

9 120 120.0

DIA


1 80 80.00

2 80 80.00

3 80 80.004 100 100.00

5 100 100.00

6 100 100.00

7 120 120.00

8 120 120.00

9 120 120.00

+a D*R P 2<

+a D*R P 2<



Da"os o("e%$dos .ara la .re!$s$o% $%"erad$a

N R D$a 1 R D$a 21 66.615 65.264

2 65.614 64.244

3 64.812 65.3664 65.590 65.877

5 64.292 65.038

6 64.490 64.397

7 65.237 64.596

8 65.146 65.146

9 66.442 66.442

To"ales 588:237 586:369Proed$os 65:36 65:152y)) 1760.325

3n 9

N 27

y)),ro!ed"o 65.1972

14.0574

0.3798

13.6776

e%"e de Var$a!$% Sa de CadradosEn(re (ra(a!"en(os 0.3798

Error &Den(ro de (ra(a!"en(o' 13.6776

o(al 14.0574

C!lculo de lo) e)tiado) de la) varianza)

Valores es("!ados de la /ar"ana y ,re+"s"on "n(er!ed"aVar"ana de la re,e(""l"dad 0.570

-0.042

Var"ana de la ,res"+"on "n(er!ed"a 0.528

%D re,e(""l"dad &' 1.158

%D ,re+"s"on "n(er!ed"a 1.650

L"!"(e de e,e(""l"dad 2.093

L"!"(e de e,rod+""l"dad 2.014

%

%(ra(a!"en(o

%E

o!,onen(e de la /ar"ana en(re d"ass$2 d



N[ D"a 11 66.615

2 65.614

3 64.812

4 65.590

5 64.292

6 64.490

7 65.237

8 65.146

9 66.442

s$2 0.640

&S'Qs$2 5.12

los$2 -0.19368&S'Qlo$2 -1.5495

2.2795957886

los,$2 0.357857846

#Slos$2 -5.9175

H 8.0646894669

/ 8

5; S.es"oValor +al+lado

rea ar(ley 1.29rea de o+@ran 0.3745

rea de ar(le(( 18.5698

lo y ,ro!ed"o los1.815310 -0.0968

1.813929 -0.15231.813446 -0.1207

s,$2

KAIO DE LO%



R

N e"=

1 1.2552 0.254

3 -0.547

4 0.230

5 -1.068

6 -0.870

7 -0.123

8 -0.213

9 1.082

10 0.112

11 -0.90812 0.214

13 0.725

14 -0.114

15 -0.756

16 -0.557

17 -0.006

18 1.290

19 -0.020

20 -0.836

21 0.28622 0.798

23 -0.625

24 -0.683

25 -0.484

26 1.437

27 0.128



PR*C,S,ON D*+ *TODO: CASO 1: /N' 90

Pe%d$e%"e (1 2.573E*01

,%"er!e."o ( -3.277E*00

SeJal a%al$"$!a Co%!e%"ra!$o% e%!o%"rada Re!.erado

1367.8000 53.29 66.615

1347.2000 52.49 65.614

1330.7000 51.85 64.812

1684.2000 65.59 65.590

1650.8000 64.29 64.292

1655.9000 64.49 64.490

2010.8000 78.28 65.237

2008.0000 78.18 65.146

2048.0000 79.73 66.442

ro!ed"o 65.360

s 0.800

DE 1.224

0.615

8

+ ecupe"a%$ ($"%e!a%$s)

92.240

92.414

92.518

92.563

92.602

92.746

I &\'



95.475

95.772

95.830

*C,S,ON D*+ *TODO: CASO 1: *TODO P+AC*-O CARADO

Pe%d$e%"e (1 2.573E*01

,%"er!e."o ( -3.277E*00


0.6707 0.15 0.096

0.6704 0.15 0.0960.6914 0.15 0.096

0.8393 0.16 0.080

0.8476 0.16 0.080

0.8507 0.16 0.080

ro!ed"o 0.088

s 0.009

DE 9.914

+ ecupe"a%$ ($"%e!a%$s)

100.181

100.226



100.380

101.375

101.746

103.326

N ,NT*RAD,A D*+ *TODO: CASO 1: *TODO P+AC*-O CA

1)


1367.8000 53.29 66.615

1347.2000 52.49 65.614

1330.7000 51.85 64.812

1684.2000 65.59 65.590

1650.8000 64.29 64.292

1655.9000 64.49 64.4902010.8000 78.28 65.237

2008.0000 78.18 65.146

2048.0000 79.73 66.442

ro!ed"o 65.360

s 0.800

DE 1.224

2)




1340.0000 52.21 65.264

1319.0000 51.40 64.244

1342.1000 52.29 65.366

1691.6000 65.88 65.877

1670.0000 65.04 65.038

1653.5000 64.40 64.3971991.0000 77.51 64.596

2008.0000 78.18 65.146

2048.0000 79.73 66.442

ro!ed"o 65.152

s 0.704

DE 1.081

3)


1335.80 52.05 65.060

1319.00 51.40 64.244

1342.10 52.29 65.3661691.60 65.88 65.877

1655.00 64.45 64.455

1653.50 64.40 64.397

1991.00 77.51 64.596

2050.30 79.82 66.516

2009.90 78.25 65.208

ro!ed"o 65.080

s 0.757

DE 1.164



R D$a 3 /R D$a 10K2 /R D$a 20 K265.060 4437.526 4259.400

64.244 4305.183 4127.263

65.366 4200.625 4272.72865.877 4302.025 4339.838

64.455 4133.411 4229.927

64.397 4158.940 4146.917

64.596 4255.855 4172.589

66.516 4244.030 4244.030

65.208 4414.518 4414.518

585:71865:8

rados de +$(er"ad ed$a de Cadrados !2 0.1899 0.3333

240.5699

26

Valores es("!ados de la /ar"ana y ,re+"s"on "n(er!ed"aVar"ana de la re,e(""l"dad 0.570

-0.042

Var"ana de la ,res"+"n "n(er! 0.570

%D re,e(""l"dad &' 1.158

%D ,re+"s"on "n(er!ed"a 1.158

L"!"(e de e,e(""l"dad 2.093

L"!"(e de e,rod+""l"dad 2.093

o!,onen(e de la /ar"anaen(re d"as s$2 d



VALIDAION DEL MODELO

D"a 2 D"a 365.264 65.060

64.244 64.244

65.366 65.366

65.877 65.877

65.038 64.455

64.397 64.397

64.596 64.596

65.146 66.516

66.442 65.208

0.496 0.574

3.97 4.59

-0.30467 -0.24134-2.4374 -1.9307

> 9 '

e oo#e%e$dad de las ar$a%asValor (alas ond"+"n on+ls"n

6.0000 ooceda)ticidad0.6333 ooceda)ticidad

5.99152c 2 tala) % / 005 ooceda)ticidad

c tala) % / 005c tala) % / 005

OK %" ONA Lo. OMEDIO

1.813000 1.813500 1.814000 1.814

-0.0600

-0.0400

-0.0200

0.0000

Kr?+o ,ara de(er!"nar la ,os""l"da



,CO D* +OS R*S,DUOS CONTRA +OS VA+OR*S AQUSTADOS

y a=s(ado

65.36065.360

65.360

65.360

65.360

65.360

65.360

65.360

65.360

65.152

65.15265.152

65.152

65.152

65.152

65.152

65.152

65.152

65.080

65.080

65.08065.080

65.080

65.080

65.080

65.080

65.080

-0.1600

-0.1400

-0.1200

-0.1000

-0.0800

Lo y ,ro!ed"

+o# s$

65.050 65.100 65.15

-1.500

-1.000

-0.500

0.000

0.500

1.000

1.500

2.000

K]IO

e"=



R,CO D* PRO-A-,+,DAD NORA+ D* +OS R*S,DUOS

N[ e"= ordenados -s+ore

1 -2.71 -2.085

2 -1.50 -1.593

3 -1.35 -1.325

4 -1.26 -1.128

5 -1.11 -0.967

6 -1.10 -0.828

7 -1.09 -0.704

8 -1.07 -0.589

9 -1.06 -0.482

10 -0.91 -0.380

11 -0.76 -0.28212 -0.74 -0.187

13 -0.57 -0.093

14 -0.04 0.000

15 0.09 0.093

16 0.25 0.187

17 0.36 0.282

18 0.44 0.380

19 0.44 0.482

20 0.46 0.589

21 0.51 0.70422 0.74 0.828

23 1.65 0.967

24 2.04 1.128

25 2.22 1.325

26 2.49 1.593

27 3.60 2.085



Pre(a L de D$xo%

X11 &M"n' 0.049

X11&May' 0.017

0)564%" X11 X +r"("+o se re+@aa el da(o


X+r" &J C0;05'



K!ax 1.5686

2)215


/N ' 6 0

Pre(a L de D$xo%

X10 &M"n' 0.014

X10&May' 1.000

0)628

K+r"("+o &J 0;05; 2

X+r" &J C0;05'



%" X11 X +r"("+o se re+@aa el da(o


K!ax 0.9513

2)02


ADO /N ' 90

Pre(a de la Re#la de Ga.eled$a%a 65:23

N A(sol"as de las ed$a%as1 1.38

2 0.38

3 0.42

4 0.35

5 0.95

6 0.75

7 0.00

8 0.09

9 1.20

ed$a%a A-S :42

AD :63

S$ alor %oral$ado H 3<5 se !o%s$dera alor

Pre(a de la Re#la de Ga.el

ed$a%a 65:14

K+r"("+o &J 0;05; 2




2 0.90

3 0.22

4 0.73

5 0.11

6 0.75

7 0.55

8 0.00

9 1.30

ed$a%a A-S :55

AD :82



ed$a%a 65:6


2 0.903 0.22

4 0.73

5 0.69

6 0.75

7 0.55

8 1.37

9 0.06

ed$a%a A-S :69

AD 1:3





N/R D$a 30 K2 1 1.47

4232.806 2 0.47

4127.263 3 0.33

4272.728 4 0.444339.838 5 0.85

4154.429 6 0.66

4146.917 7 0.09

4172.589 8 0.00

4424.423 9 1.30

4252.052 ed$a%a A-S :55

AD :82


"a(lado3.4028

0

A(sol"as de las ed$a%asd$a 1



3 n 3

500 1.815000 1.815500

de rans:or!a+"n



65.200 65.250 65.300 65.350 65.400

DE LO% E%IDALE%

Valores a=s(ados y



-4.00 -3.00

Gráfico de pr

RES

!-S"ORE



2.19

0.60

0.67

0.56

1.50

1.19

0.00

0.14

1.91

(erra%"e

Noral$adasA(sol"as



0.14

1.11

0.27

0.90

0.13

0.92

0.67

0.00

1.59

(erra%"e

0.11

1.110.27

0.90

0.85

0.92

0.67

1.68

0.08

(erra%"e

ed$a%a 65)146

Noral$adasA(sol"as

Noral$adasA(sol"as



0.12 0.09 1.80 0.14

0.90 0.90 0.57 1.11

0.22 0.22 0.41 0.27

0.73 0.73 0.54 0.900.11 0.69 1.05 0.13

0.75 0.75 0.80 0.92

0.55 0.55 0.11 0.67

0.00 1.37 0.00 0.00

1.30 0.06 1.59 1.59

(erra%"e

A(sol"as de lased$a%as d$a2

A(sol"as de lased$a%as d$a 3

Nor!al"adasAsol(as) D"a1

Nor!al"adasAsol(as) D"a 2



2.00 -1.00 0.00 1.00 2.00 3.00 4.00

-2.500

-2.000

-1.500

-1.000

-0.500

0.000

0.500

1.000

1.500

2.000

2.500

babilidad normal de los residuos

DUOS ei ORDENADOS



0.11

1.11

0.27

0.900.85

0.92

0.67

1.68

0.08

Nor!al"adasAsol(as) D"a 3

LINEALIDAD DIGOXINA 20µgmL

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