Molecular basis of infrared detection by...
Transcript of Molecular basis of infrared detection by...
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Molecular basis of infrared detection by snakes
По мотивам:
Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS, Julius D. Molecular basis of infrared detection by snakes. Nature 464, 1006-1011
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Кто?
Гремучие змейки (ямкоголовые) Crotalinae
Питончики Pithonidae
Удавчики Boidae
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5-10 : 1в пользу ЯМКОГОЛОВЫХ
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Anatomy of the pit organ
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Nerve pathways associated with the infrared sensory system
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Принцип
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Несколько слов об ЭТОМ
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Photons or Heat
Идея1:
There are NO opsin-like sequences in TG of any snake species examined
Heat-activated membrane currents in TGhave been described
Heat
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Идея2:Сравним gene expression в TG и DRG
TRPA1 в 400 раз больше в TG чем в DRGвсего остального примерно поровну. Ничё се повезло, а!
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Копаем дальше:
TRPA1 in mammals ~ 25% of neurones (TG or DRG)
rattlesnake ~ 60% of TG neurones (0 in DRG)
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Snake TRPA1 is a heat-activated channel In HEK
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Drosophila
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Ancient snakes use TRPA1 to sense infrared radiation
Питоны и удавы Гремучие змеи
> 30 млн лет
эволюция
в 65 раз в 170 раз
TG > DRG TG > DRG
30 C32 C
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Непонятка:
"The pit sensory system is clearly functional with sensory ending temperatures well below the reported 28 °C threshold,"
Snakes can detect a human hand better in a refrigerated chamber than at room temperature
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Merci beaucoup!