Product Presentation Metris 2009LBN

8/14/2019 Product Presentation Metris 2009LBN

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Product Presentation

Instruments for Animal

Behavioral Research

Metris b.v. 2009


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ContentContent

s Company overviewCompany overview

s

ProductsProducts

s Importance of the energy parameter inImportance of the energy parameter in

Behavioral PharmacologyBehavioral Pharmacology


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Company overviewCompany overview

GoalGoal

Provide turnkey solutions / expertise in the area ofProvide turnkey solutions / expertise in the area ofautomatic animal behavior analysis.automatic animal behavior analysis.

ProductsProducts MarketsMarketsLABORASLABORAS Pharmaceutical industryPharmaceutical industrySonoTrackSonoTrack Research institutes/CROsResearch institutes/CROsThird Party productsThird Party products Universities/ Academic HospitalsUniversities/ Academic Hospitals

ActivitiesActivitiesProduct Development,Product Development,Marketing / Sales ,Marketing / Sales ,Assembly and Product support.Assembly and Product support.


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HistoryHistory

s 5/19995/1999 Metris BV startMetris BV starts 9/20019/2001 Delivery of first LABORAS forDelivery of first LABORAS for

Windows systemsWindows systems

s 2/20052/2005 Introduction SONOTRACK (UltrasoundIntroduction SONOTRACK (Ultrasoundrecording and analysis)recording and analysis)

s 7/20057/2005 Distributor SleepSign for Animals (EU)Distributor SleepSign for Animals (EU)s 8/20068/2006 Introduction LABORAS 2.0Introduction LABORAS 2.0s 12/200812/2008 Introduction SonoTrack USV PlaybackIntroduction SonoTrack USV Playbacks 1/20091/2009 Introduction SonoTrack 2.0Introduction SonoTrack 2.0

s Since 2001Since 2001 400 400 platforms are delivered andplatforms are delivered andover 50 references on our website support theover 50 references on our website support the

value of LABORAS as experienced byvalue of LABORAS as experienced byresearchersresearchers


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Company RelationsCompany Relations

DistributorsDistributorss Neuroscience Inc. (Japan)Neuroscience Inc. (Japan)s Kuo Yang Scientific Corporation (Taiwan)Kuo Yang Scientific Corporation (Taiwan)s

Mirae Korea Inc. (South Korea)Mirae Korea Inc. (South Korea)s Medi Analytika Ltd. (India)Medi Analytika Ltd. (India)s AH Medical Supply (China)AH Medical Supply (China)s Radon Medical (Turkey)Radon Medical (Turkey)

CooperationsCooperationss DataSciences Telemetry (USA)DataSciences Telemetry (USA)s Kissei (Japan)Kissei (Japan)s Porsolt (France)Porsolt (France)s National Instruments (USA, NL, Armenia)National Instruments (USA, NL, Armenia)


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LABORAS

s LABORAS is a fully automaticLABORAS is a fully automaticsystem for continuous behaviorsystem for continuous behavior

recognition and tracking of smallrecognition and tracking of smallrodents (mice and rats)rodents (mice and rats)

s LABORASLABORAS replaces, reducesreplaces, reducesand refines behavioral scoring byand refines behavioral scoring by

human observershuman observers

s LABORAS sets a new standardLABORAS sets a new standardin the area of behavioralin the area of behavioralobservation instrumentsobservation instruments

What is LABORAS?What is LABORAS?


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1980 1990 2000 2010

Infrared beam

matrix (8x5) Infrared beam

matrix (3D)

LABORAS

2.0

Infrared beam

matrix (4x3)

ANIMEX

Video tracking

(single point) Video tracking

(multi point)

LABORAS

1st. generation

Low

resolutionXYt

rack

high

0

no.ofbehavio

rs

>10

Evolution of automatic tracking& behavioral observation

systems


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LABORAS techniqueLABORAS technique(1/3)(1/3)

MainMaincomponentscomponents

LABORASLABORAS

s MeasurementMeasurementplatform(s)platform(s)

s ElectronicsElectronics(e.g. amplifiers &(e.g. amplifiers &

control & A/Dcontrol & A/Dconv.)conv.)

s LABORAS softwareLABORAS softwarefor Windowsfor Windows


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x

y

t

Behaviors

Behavior

Track

AdministrationA/Dconv.

A

mp.Ctr.

&

Tracking

Results

ctr

ctr

Measurement

platform(s)

Electronics

(@ platform) PC + software

Graphs Tables

t behav

0

t x y

0.500.75

0.2510

49

3 10688

05.259.7515.5

immobeatdrinkgroom

Export

ASCII

e.g. MS-Excel

SPSS

SAS JMP

Electronic

Control

Unit

LABORAS techniqueLABORAS technique (2/3)(2/3)


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LABORAS techniqueLABORAS technique (3/3)(3/3)

Locomotion

Scratching

Example of recognition of behavioralExample of recognition of behavioralfeaturesfeatures

Fast up and down

movement of the hind

foot, rubbing the side of

the body, neck

and face.


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Tracking measurementTracking measurement

Tracking information provided by LABORASTracking information provided by LABORAS

High resolution XY position trackHigh resolution XY position track Velocity data (average, max.)Velocity data (average, max.) Distance traveledDistance traveled Position distribution (details like favorite spots)Position distribution (details like favorite spots) Circling / turning (Clockwise and counter-clockwise circleCircling / turning (Clockwise and counter-clockwise circle

count, avg. circle size, avg. circling speed, avg. time incount, avg. circle size, avg. circling speed, avg. time incircle)circle)

Sociality Cage (preference to visit specific compartmentsSociality Cage (preference to visit specific compartmentsin cage)in cage)

Estimation of energy useEstimation of energy use (in development)(in development)


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Detection of behaviorsDetection of behaviors

LABORAS distinguishes more than 16LABORAS distinguishes more than 16different rat and mouse behavioursdifferent rat and mouse behaviours

Normal behavioursNormal behaviours LocomotionLocomotion

ImmobilityImmobility

RearingRearing

ClimbingClimbing

EatingEating

DrinkingDrinking

GroomingGrooming

Special behavioursSpecial behaviours Scratching (mice)Scratching (mice)

Seizures - tonic-clonic convulsions,Seizures - tonic-clonic convulsions,barrel-rolls, Racine P4 and P5barrel-rolls, Racine P4 and P5(mice)(mice)

Hind limb licking / Formalin testHind limb licking / Formalin test

(rat)(rat) Purposeless chewing (rat)Purposeless chewing (rat)

Wet dog shakes (rat)Wet dog shakes (rat)

Headshakes (rat)Headshakes (rat)

Head twitches (rat)Head twitches (rat)


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LABORASLABORASconfigurationsconfigurations

Configuration variablesConfiguration variabless Up to to 8 measurement platforms connected to oneUp to to 8 measurement platforms connected to one

computercomputers Species: mice, rat or bothSpecies: mice, rat or boths Tracking and Behavior software modules:Tracking and Behavior software modules:

TrackingTracking

Normal behaviorsNormal behaviors

Special behaviorsSpecial behaviors

s Integration with Telemetry (Behavior & Psychology)Integration with Telemetry (Behavior & Psychology)s Sociality Cage (special cage that enables sociability test)Sociality Cage (special cage that enables sociability test)s User interface specialsUser interface specials

GLPGLP

Independent start of the platformsIndependent start of the platforms


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Examples of resultsExamples of results


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LABORAS QualificationLABORAS Qualification(1/6)(1/6)

s Operational Validation:Operational Validation: Does LABORAS performs as advertisedDoes LABORAS performs as advertised

Explained in the following sheetsExplained in the following sheets

s Pharmacological ValidationPharmacological Validation Does LABORAS assist me with my researchDoes LABORAS assist me with my research

Metris role to assistMetris role to assist E.g. new experiments or new algorithmsE.g. new experiments or new algorithms

s CertificatesCertificates

GLP (Laboratory req.) , CE / FCC (electricalGLP (Laboratory req.) , CE / FCC (electrical


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Camera

Platform

Electronics


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timet

durationTestT

TatobserverstimecumulativeofmeancumTObs

tatobserverstimecumulativeofmeancumtObs

tatLABORAStimecumulativecumtLab

cumcumobscumcum TObsTtObsttObstLab

=

=

=

=

=

+++

)(

)(

)(

)(%4%1)(%5)(5.1)()(

Grooming (Rat14) : 90%

0

100

200

300

400

500

600

700

800

0 500 1000 1500 2000 2500 3000 3500

Time (s)

Cumulat.timeGroomin

LABORAS

Alex

Lee

Mean Obs

Boundary-

Boundary+



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Immobility (Rat01): 90%

0

200

400

600

800

1000

1200

1400

1600

1800

0 600 1200 1800 2400 3000 3600

Time (s)

Cumulativetime(s)

LABORAS

Alex

Tania

Heleen

Mean Obs.

Bound -10%

Bound +10%


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Validation ResultsValidation Results Correlation with human observers (accordingCorrelation with human observers (according

to validation criterion)to validation criterion)

Locomotion, ClimbingLocomotion, Climbing > 95%> 95% Immobility, GroomingImmobility, Grooming > 90%> 90% Eating, Drinking, RearingEating, Drinking, Rearing > 80%> 80%

Special behaviorsSpecial behaviors > 80-90%> 80-90%

Since 2001Since 2001 400 400 platforms are delivered andplatforms are delivered andover 50 references on our website support theover 50 references on our website support thevalue of LABORAS as experienced byvalue of LABORAS as experienced byresearchersresearchers


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Development of new algorithmsDevelopment of new algorithms Good animal behavior definitionGood animal behavior definition

Proper definition of the experiment protocolProper definition of the experiment protocol

- and use of the LABORAS experiment administration- and use of the LABORAS experiment administration

Choice of pharmacological relevant behaviorsChoice of pharmacological relevant behaviors

Good correlation with the real behavior (acceptationGood correlation with the real behavior (acceptation

criterion)criterion)- Not always human observer reference- Not always human observer reference

Results presentationResults presentation- Recording and Presentation of result data- Recording and Presentation of result data

- Use of previous raw data/ result summaries- Use of previous raw data/ result summaries

Enabling the full benefit of LABORASEnabling the full benefit of LABORAS


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Examples ofExamples of

performanceperformance

Normal BehavioNormal Behaviou(rat)(rat)


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Wet DogWet DogShakesShakes

(rat)(rat)


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HeadHeadTwitchesTwitches

(rat)(rat)


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CirclingCircling(rat)(rat)


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Sociality Cage (mice)Sociality Cage (mice)


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Applications LABORASApplications LABORAS

s LABORAS application areas are:LABORAS application areas are:

(behavioral assessment in)(behavioral assessment in) Drug DevelopmentDrug Development PhenotypingPhenotyping

Safety PharmacologySafety Pharmacology Lab. animal scienceLab. animal science ToxicologyToxicology

s Typical customers areTypical customers are::

Pharmaceutical CorpPharmaceutical Corp CROs (Contract Research Org.)CROs (Contract Research Org.) Academic institutesAcademic institutes Lab. animal suppliersLab. animal suppliers

HospitalsHospitals GovernmentalGovernmental

OrganizationsOrganizations


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Monitoring of behavioral changes and effects in:Monitoring of behavioral changes and effects in:

s Drug Development Drug Discovery research Efficacy studies of new compounds

Long term observation tests (e.g. circadian rhytm,eat-drink patterns)

Experimentally induced behaviors (e.g. grooming,drinking, movement patterns, hindlimb-licking / formalin-test, scratching, WDS, Head Shakes)

s Safety Pharmacologys Toxicologys Phenotyping research

High Capacity Phenotyping with transgenic mice


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s Animal models based on behavioral assessmentin home cage environment Normal behaviors

Drug induced behaviorss Pain studies

Automated Formalin Test

s Social Interaction Preference studies (with stranger and familiar mouse

Sociality cage)s Animal welfare studies

Cage enrichment studies

Behavioral effects of manipulation of animal


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Examples of LABORAS applications in drug discoveryExamples of LABORAS applications in drug discovery

Analysis of social behavior (for

amongst other Autism research)

Sociability Test

Skin protective effectsDermatology test (scratching)

Integrated cardiovascular, CNS

and behavioral data

Telemetry & Behavior

Analgesic propertiesPain test (formaline induced

hindlimb licking)

E.g. sedative, stimulant,

anxiolytic, anxiogenic properties

Open field test

Adverse drug effectsPrimary observation test

Target discovery for future drug

development

Behavioral phenotyping

transgenic mice

RESULTTEST


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Pharmacological efficacy of

(potential) leadsPharmacological antagonist

efficacy, eg. anticonvulsant

activity

Effect on Pharmacologically

induced effects, such as m-CPP hypolocomotion and

hypophagia 8-OH-DPAT hyperlocomotion d-Amphetamine hyperactivity Angiotensin II polydypsia

Orexin-A induced grooming Excessive climbing Turning/circling behavior Wet Dog Shakes (WDS) Head Shake & Head Twitch Seizure

RESULTSTEST



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Hypo- or hyperphagia; Hypo- or

polydipsia

Disturbed feeding / drinking

patterns (Eating / Drinking)

Metabolic effectsEnergy spend

Detailed Exploration/Anxiety

measure

Sniffing, Digging, JumpingEfficacy and safety issuesHeart beat

Adverse effectsRespiration

FUTURE APPLICATIONS

Antagonism of pharmacologically

induced effects, such as Dyskinesia Startle response

NEAR FUTURE APPLICATIONS



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Overall benefits LABORASOverall benefits LABORAS

General benefits for customerGeneral benefits for customer Standard and objective methodStandard and objective method

Eliminates inter- and intra observer deviationEliminates inter- and intra observer deviation

Does not require trained or experienced ratersDoes not require trained or experienced raters

Reduces time & costs (>75% reduction)Reduces time & costs (>75% reduction)

Results are almost immediately availableResults are almost immediately available

Many independent parameters can beMany independent parameters can bemeasured with just one system (Tracking &measured with just one system (Tracking &

behavior recognition combined in singlebehavior recognition combined in single

system)system)

Growth potential to determine several newGrowth potential to determine several new

behavioral and tracking parametersbehavioral and tracking parameters


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Overall benefits LABORASOverall benefits LABORAS

Important benefits for experimentImportant benefits for experiment Independent of light conditionsIndependent of light conditions

Home cage environment and non-invasiveHome cage environment and non-invasivemethod (stress minimized)method (stress minimized)

Large scale observational experimentsLarge scale observational experiments

possiblepossible

Long test periods possibleLong test periods possible More consistent resultsMore consistent results


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SONOTRACKSONOTRACK


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What is SONOTRACK?What is SONOTRACK?

SONOTRACK records, visualizes and plays backSONOTRACK records, visualizes and plays backUltrasound CallsUltrasound Calls

SONOTRACK records theSONOTRACK records the full spectrumfull spectrum fromfrom15kHz up to 100kHz15kHz up to 100kHz

SONOTRACK recordsSONOTRACK records 4 independent4 independent ultrasoundultrasoundchannelschannels

SONOTRACK can easily be adjusted toSONOTRACK can easily be adjusted toexperimental environment and isexperimental environment and is easy to useeasy to use


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Ultrasonic VocalizationsUltrasonic VocalizationsHearing range of Animals

chinchil

shee

hors

co

raccoo ra

bb

ferre

do h

edgeho

guineap

gerbi

cat

opossu

rat

mous b

a

belugawha

porpoi

mot

1

10

100

1000

10000

100000

1000000

chinchilla

sheep

horse

cow

raccoon

rabbit

ferret

dog

he

dgehog

gu

ineapig

gerbil

cat

opossum

rat

mouse

bat

belug

awhale

porpoise

moth

Freq.range(

Log


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What is SONOTRACKWhat is SONOTRACK

SONOTRACK can be used for long termSONOTRACK can be used for long term

experimentsexperiments

SONOTRACK recognizes and counts UltrasonicSONOTRACK recognizes and counts Ultrasonic

Vocalizations in user definable frequencyVocalizations in user definable frequency

bandsbands

SONOTRACK offers a new approach forSONOTRACK offers a new approach forcharacterization of animal behaviorcharacterization of animal behavior


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SONOTRACK ApplicationsSONOTRACK Applications

SONOTRACK can be used to monitor animalSONOTRACK can be used to monitor animalwelfare and interaction between animalswelfare and interaction between animalsbased on the ultrasonic vocalizations of thebased on the ultrasonic vocalizations of the

animalsanimals

Typical research areas:Typical research areas: PainPain

AnxietyAnxiety

StressStress DepressionDepression

Social interactionSocial interaction

Animal WelfareAnimal Welfare


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SONOTRACK ApplicationsSONOTRACK Applications

Playback of Ultrasounds to the animalPlayback of Ultrasounds to the animal(stimulus)(stimulus)- playing back parts or complete recordings- playing back parts or complete recordings

- playing back specific (artificial) frequency- playing back specific (artificial) frequencypatternspatterns


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Examples of ResultsExamples of Results


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MarmosetMarmoset

Rats, Mother & PupRats, Mother & Pup

Ultrasound VocalizationsUltrasound Vocalizations


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Example of resultsExample of results


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What isWhat isSleepSign?SleepSign?s Software for scoring of sleep stagesSoftware for scoring of sleep stages

s Based on EMG and EEG signalsBased on EMG and EEG signals

s Sleep stages can be scored in a manual modeSleep stages can be scored in a manual modeas well as well as automaticallyas well as well as automatically

s Scores pre-assigned sleep stages (such as REM,Scores pre-assigned sleep stages (such as REM,WAKE, SWS) and up to 3 user defined vigilanceWAKE, SWS) and up to 3 user defined vigilancestagesstages


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Special featuresSpecial features

s Works with wireless or wired EMG and EEGWorks with wireless or wired EMG and EEG

signalssignalss In depth analysis using Hypnograms and TrendIn depth analysis using Hypnograms and Trend

GraphsGraphs

s Various analysis functions, incl. Stage Graphs,Various analysis functions, incl. Stage Graphs,

Vigilance State Parameter Display, FFT analysisVigilance State Parameter Display, FFT analysiss Integrated with VideoIntegrated with Video


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Application areasApplication areas

s Pharmaceutical ResearchPharmaceutical Research

s Sleep Disorder Studies and SleepSleep Disorder Studies and Sleeppattern Analysispattern Analysis


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Integration of SystemsIntegration of Systems

Integration of systems such as LABORAS, Video,Integration of systems such as LABORAS, Video,DSI Telemetry, SonoTrack & SleepsignDSI Telemetry, SonoTrack & Sleepsign

Less Experiments & Experimental lead timeLess Experiments & Experimental lead time

Less Resources (animals, researchers & money)Less Resources (animals, researchers & money)

Integrated analysis of parameters from differentIntegrated analysis of parameters from differentdomains collected from the same experimentdomains collected from the same experiment

- Behavioral data and Tracking dataBehavioral data and Tracking data- Psychological dataPsychological data

- SoundsSounds

- Sleep stagesSleep stages


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Integration of SystemsIntegration of Systems

WithWithSonotrackSonotrack

LABORASLABORAS WithWithSleepSignSleepSign

Example of integration in LaborasExample of integration in Laboras

ENERGY &


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ENERGY &ENERGY &

PHARMACOLOGYPHARMACOLOGY

Behavior and external / internal conditionsBehavior and external / internal conditionsEnvironmentEnvironment -- External conditionExternal condition

Process in the Body Internal conditionProcess in the Body Internal condition

The study of animalThe study of animalbehaviour, particularlybehaviour, particularly

from evolutionary andfrom evolutionary and

ecological viewpoints,ecological viewpoints,

has been one of thehas been one of the

major growing pointsmajor growing pointsin biology over the lastin biology over the last

15 years.15 years.

G &ENERGY &
http://www.google.nl/imgres?imgurl=http://hotpot.klascement.net/aanbod/roffel.sanne/rat.jpg&imgrefurl=http://hotpot.klascement.net/aanbod/roffel.sanne/d_of_t.htm&h=495&w=512&sz=301&tbnid=4omgqKTACJTvdM::&tbnh=127&tbnw=131&prev=/images%3Fq%3Drat%2Bphoto&hl=nl&usg=__U-Jhsg3lRv2RfEaCJg8g2xKmxX4=&ei=PtgLSq6BHsO9-AbBgK2_Bg&sa=X&oi=image_result&resnum=4&ct=image


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ENERGY &ENERGY &

PHARMACOLOGYPHARMACOLOGYBasic structureBasic structure

BEHAVIOR =BEHAVIOR =Function { Internal stimulus, external stimulus}Function { Internal stimulus, external stimulus}

ENERGY &ENERGY &


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ENERGY &ENERGY &


Information filtering and DecisionInformation filtering and Decision

Internal

Stimuli

External

Stimuli

Behaviorr

Decision

Animal

Body

ENERGY &ENERGY &


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ENERGY &ENERGY &

PHARMACOLOGYPHARMACOLOGYAnimal behavior and environmentAnimal behavior and environment

Sensory systemSensory system

1. inernoreceptor convey information within1. inernoreceptor convey information within

organismsorganisms2. Proprioreceptor- report information position of the2. Proprioreceptor- report information position of the

body partbody part

3. Externoreceptor- obtains information about the3. Externoreceptor- obtains information about the

outside (environment and ecology)outside (environment and ecology)

4. Sometoreceptor capture events on the body4. Sometoreceptor capture events on the body

surfacesurface

5. Teloreceptor- monitor stimuli at a distance from5. Teloreceptor- monitor stimuli at a distance from

the bodythe body

ENERGY &ENERGY &


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ENERGY &ENERGY &


Animal behavior and environmentAnimal behavior and environment

StructureStructure

1. Information1. Information2. Motivation2. Motivation

3. Development3. Development

4. Decision4. Decision

Types of informationTypes of information

Genetics- evolutionGenetics- evolutionCompetition and RiskCompetition and Risk

Investigation informationInvestigation information

RecognitionRecognition

AnalysisAnalysis

Data monitoryData monitorySaving and summariseSaving and summarise

ENERGY &ENERGY &


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ENERGY &ENERGY &


Information ProcessInformation Process

Transform

Information

Filtering

Detection

Information

Sensory cells

Transmit

Information

Nerve cells

Chemical

messenger

Integration

Information

Nerve Cells

Action

Information

Muscle Cells

Store

Information

Cognition and

brain

ENERGY &ENERGY &


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ENERGY &ENERGY &


Processing information in the animal bodyProcessing information in the animal body

SensoryCells NerveCells

Chemical

messengers MuscleCells

Behavior

Sensory Cells

Pick up different changes in the

environmentNerve Cells

Transmit and integrate information

Chemical messenger

Transmit Chemical information (more

leisurely time than nervous system)

Muscle CellsTransform information from the nervous

system into action

ENERGY &ENERGY &


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ENERGY &ENERGY &


Nervous System (CNS)Nervous System (CNS)Advanced nervous systemAdvanced nervous system

have five major components,have five major components,

linking stimulus perception andlinking stimulus perception and

motor respond.motor respond.

Sensory Cells

Sensory Neuron

Motor Neuron

Interneuron Effector

Sensory Cells acting sensorySensory Cells acting sensory

as sensory receptoras sensory receptor

Sensory Neuron-carryingSensory Neuron-carrying

impulses from the sense cellsimpulses from the sense cells

Motor neurons - carryingMotor neurons - carrying

impulses into effector cellsimpulses into effector cells

Interneuron- linking sensorInterneuron- linking sensor

neuron and motor neuronneuron and motor neuron

Effector- Effector organEffector- Effector organ

ENERGY &ENERGY &


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ENERGY &ENERGY &

PHARMACOLOGYPHARMACOLOGYAnimal behavior and environmentAnimal behavior and environment

BEHAVIOR= Function {BEHAVIOR= Function {Process in the BodyProcess in the Body, nervousnervous

system structure, nervous function, hormonal effects ,system structure, nervous function, hormonal effects ,biological clocks, perceptual mechanisms, Genes,biological clocks, perceptual mechanisms, Genes,

internal/external stimulus filtering}internal/external stimulus filtering}

ENERGY &ENERGY &


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ENERGY &ENERGY &


External factor and environmental variables

Temperature = function { temperature control Unit , CV }Temperature = function { temperature control Unit , CV }

Airflow = function air-conditioning}Airflow = function air-conditioning}

Barometric pressure = function { place, time }Barometric pressure = function { place, time }

Humidity = function { office level or place }Humidity = function { office level or place }

Visual effect = function { walking researchers in the laboratory}Visual effect = function { walking researchers in the laboratory}

Light = function { lights control unit}Light = function { lights control unit}

Sounds = function { sounds generating equipment, voices }Sounds = function { sounds generating equipment, voices }Vibration = function { refrigerators, ventilators, PCs, specific equipment }Vibration = function { refrigerators, ventilators, PCs, specific equipment }

Elektromagnetic waves = function{ transmitting equipment, magnets}Elektromagnetic waves = function{ transmitting equipment, magnets}

Smell = function {specific gases, parfums, etc,}Smell = function {specific gases, parfums, etc,}

ENERGY &ENERGY &


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ENERGY &ENERGY &


Rule of energy preservation of theRule of energy preservation of thebodybody

E = K + P = constantE = K + P = constant (Formula(Formula of energetic balance)of energetic balance)s Potential Energy of the BodyPotential Energy of the Body

P = U+P = U+ (( TT

++PP

))

-U-U is the change in biochemical energyis the change in biochemical energy

- - is the internal energyis the internal energy

- T- T is the entropy energyis the entropy energy

- Pv- Pv is the thermodynamic energyis the thermodynamic energy

THE IMPORTANCE OF THETHE IMPORTANCE OF THE ENERGYENERGY


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PARAMETER INPARAMETER IN

BEHAVIORAL PHARMACOLOGYBEHAVIORAL PHARMACOLOGY

sKinetical energy of bodyKinetical energy of body

E (Locomotion) = Mv/2E (Locomotion) = Mv/2

VV = velocity, M = total mass of body= velocity, M = total mass of body

E (Oscillation) = m R/2E (Oscillation) = m R/2

= radial frequency, R = radius of oscillation, = radial frequency, R = radius of oscillation,

m = mass of oscillating body partm = mass of oscillating body part

Mv/2Mv/2 mmR/2R/2++ E k =E k =

THE IMPORTANCE OF THETHE IMPORTANCE OF THE ENERGYENERGY


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PARAMETER INPARAMETER IN

BEHAVIORAL PHARMACOLOGYBEHAVIORAL PHARMACOLOGY

s Kinetical energy of bodyKinetical energy of bodyE (E (LocomotionLocomotion)) is the kinetic energyis the kinetic energy

resulting from:resulting from: Locomotion, Walking, Rearing, ClimbingLocomotion, Walking, Rearing, Climbing

E (E (OscillationOscillation)) is the kinetic energyis the kinetic energy

resulting from different repetitiveresulting from different repetitivemovements:movements:

Scratching, Grooming , Chewing, Sniffing, Wet DogScratching, Grooming , Chewing, Sniffing, Wet Dog

Shakes, Head Shakes, Head Twitches, TremorsShakes, Head Shakes, Head Twitches, Tremors

DetectionDetection recognitionrecognition andand


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Detection,Detection, recognitionrecognition andand

registration ofregistration of behaviorbehavior

Locomotion

ScratchingFast up and down

movement of the hind

foot, rubbing the side of

the body, neck

and face.

Detection of behavioral featuresDetection of behavioral features


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LABORAS HS SignalLABORAS HS Signal

AnalogAnalog DigitalDigital

E (E (OscillationOscillation)) // E (E (LocomotionLocomotion))


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E (E (OscillationOscillation)) // E (E (LocomotionLocomotion))

spectrogramspectrogram

Energy spectrogram

012

34567

89

10

HT HSWDS

Paw

Licking

Scra

tchingSeizure

Groo

mingEatingDrinking

Chewing

Loco

mmotion

Rearing

Immo

bilityCl

imbing

Behavior

Energy

Energy

For Fast Efficient & Q alitFor Fast Efficient & Quality


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More information mail: [email protected] information mail: [email protected]

Metris BVMetris BV

Kruisweg 825Kruisweg 825

2132 NG Hoofddorp2132 NG HoofddorpPhone:+31 23 5623400Phone:+31 23 5623400

Fax:Fax: +31 23 5623425+31 23 5623425

www.metris.nlwww.metris.nl

Questions?Questions?

For Fast, Efficient & QualityFor Fast, Efficient & Quality

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Product Presentation Metris 2009LBN

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