SEROTONINA

INTRODUCCIÓN

Serotonina es Producida

tryptophantransporter

tryptophan TRY OH5HTP

AAADC

VMAT2

5HT (serotonin)

Acción de Serotonina es Terminada:

MAO-B destruye 5HTEn concentraciones altas

TransportadorDe Serotonina(SERT)

MAO-A or B destruye 5HT

Action

Receptores de Serotonina

Transportadorserotonin(SERT)

5HT1 B/Dautoreceptor

5HT1A5HT1B/D

5HT2A5HT2C

5HT3

5HT4,55HT6 5HT7

5HTX,Y,Z

5HT1 B/Daxon terminalautoreceptor

5HT1 B/Daxon terminalautoreceptor

5HT1Asomatodendriticautoreceptor

5HT1Asomatodendriticautoreceptor

Possible Functions of Postsynaptic Serotonin Receptors

inhibition de neuronasCorticales piramidales

cognitionanxiety

depressionhormones

excitation of glu release

inhibition of DA release

hallucinationssleep

excitación de neuronasCorticales piramidales

obesitymood

cognition

Regulación de liberación de DA y NE

5HT1A 5HT2A 5HT2C

Possible Functions of Postsynaptic Serotonin Receptors

mood

5HT3

regulation of inhibitory interneurons

vomitingneurotrophicfactors (e.g. BDNF)

long term memory

5HT6 5HT7

sleep

circadianrhythms

5HT1A

5HT1B/D

5HT2A

5HT2C 5HT3 5HT4,5 5HT6

5HT7

5HTX,Y,Z

regulation of various neuronal circuits