RESOLEÓMICA.
N
Carlos Pérez Ramirez
Barcelona 13 de marzo de 2013
Calcio en el citoplasma
Activación de Fosfolipasa A2
Ácido Araquidónico
5‐ Lipooxigenasa(5‐LOX)
Ciclooxigenasa(COX‐1 y COX‐2)
LeucotrienosLTE4 y LTB4
ProstaglandinasPGE2, PGD2 y TXA2
Bosman M. Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medicationprevent our body from recovering. Nutrition & Metabolism 2012, 9:32
Calcio en el citoplasma
Activación de Fosfolipasa A2
Ácido Araquidónico
5‐ Lipooxigenasa(5‐LOX)
Ciclooxigenasa(COX‐1 y COX‐2)
LeucotrienosLTE4 y LTB4
ProstaglandinasPGE2, PGD2 y TXA2
AINES
“Contraindicaciones”
1. LT: constrictor de la musculatura lisa. Relacionado con “asma”
2. PG: inhibe secreción ácida: ACIDEZ
3. Influencia negativa sobre células satélite
4. LT: Quimiotaxis para neutrófilos
Broughton G. The basic science of wound healing. Plast Reconstr Surg. 2006
Resistencia de la herida a la ruptura
Dí l l ióBroughton G. The basic science of wound healing. Plast Reconstr Surg. 2006
En el proceso de inflamación los neutrófilos son las primerascélulas reclutadas.
Serhan CN. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004 Feb;30(1):69-95.
NATURE CLINICAL PRACTICE RHEUMATOLOGY YACOUBIAN AND SERHAN OCTOBER 2007 VOL 3 NO 10
Lipoxinas
Serhan CN. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004 Feb;30(1):69-95.
ACETILAR Lipoxinas
• ÁCIDO SALICÍLICO
– CILANTRO BIOLÓGICO– ZANAHORIA BIOLÓGICA – ARÁNDANOS– POPULUS NIGRA– CÓRTEX SALIX– SÁLIX ALBA
(http://organicvalley.coop/utility/resources/reading_room/benefits.html)
NATURE CLINICAL PRACTICE RHEUMATOLOGY YACOUBIAN AND SERHAN OCTOBER 2007 VOL 3 NO 10
(Serhan, 2004)
Serhan CN. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004 Feb;30(1):69-95.
Frenar la descomposición de LIPOXINAS
• PGDH: Vit A, Vit D y omega 3
• EOR: Tymol, carvacrol, pcymene, cilantrina, en aceite esencial, pignogenol(estimulan 15-LO)
(Kisko 2005)
Frenar la descomposición de LIPOXINAS
• Tymol: ALBAHACA, ROMERO• Carvacrol: TOMILLO, ORÉGANO• P cymene: MENTA• Cilantrina: CILANTRO• Pignogenol: PIÑONES
Kisko G. 2005Kohama T. 2006
CHEST / 118 / 5 / NOVEMBER, 2000
?
Figure 7Bosman M. Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medicationprevent our body from recovering. Nutrition & Metabolism 2012, 9:32
ÁCIDO LINÓLICO
Viswanathan. Involvement of CYP 2C9 in Mediating theProinflammatory Effects of Linoleic Acid in Vascular Endothelial Cells. J Am CollNutr. 2003 Dec;22(6):502-10.
Van Dyke TE. The management of inflammation in periodontal disease. J Periodontol 2008, Aug;79(8
Suppl):1601-8.
Schwab and Serhan. Lipoxins and new lipid mediators in the resolution of inflammation Current Opinion in Pharmacology 2006, 6:414–420
Charles N. Serhan. Resolving inflammation: dual anti-inflammatory and pro- resolution lipid mediators. Nat Rev Immunol. 2008 May ; 8(5): 349–361
RELACIÓN DE GRASAS
Robert K. McNamara. Role of omega-3 fatty acids in brain development and function: Potentialimplications for the pathogenesis and prevention of psychopathology. Prostaglandins, Leukotrienes and Essential Fatty Acids 75 (2006) 329–349 .
Bosman M. Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medicationprevent our body from recovering. Nutrition & Metabolism 2012, 9:32
Generations (~30 yrs) in the Evolution of Humanity
Generations % TotalHomo habilis (1st Homo species ) 76,667 100.0Homo erectus (modern body size) 60,000 78.2Modern Homo sapiens (cranial size) 6,666 8.7Agricultural Revolution (cereals) 333 0.4 Advent of Dairying (milk, cheese etc) 200 0.26Industrial Revolution (refined sugars, 7 0.009
refined cereals, oils, canned food)Food Processing Industry (junk food) 4 0.005
Conclusión: El 95% de todas las generaciones del Homo sapiens han vivido como cazadores‐recolectores.
Cordain, L., Eaton, S.B. 1999. World Rev Nutr Diet 84:19 –73.
EPA-DHA por cada 100gr de pescado
Fedacko. Pathophysiology. n−3 PUFAs— From dietary supplements to medicines. Pathophysiology 14 (2007) 127– 132
Refined sugars, grains, vegetable oils and dairy = 70.9% of energy in the U.S. food supply
• Refined sugars, grains, vegetable oils and dairy represent Neolithic & Industrial era foods that were not present in traditional ancestral human diets
• By default, their inclusion displaces minimally processed, wild plant and animal foods.
15,7 1,43,1
3,3
4,80,8
10,623,9
17,8
18,6Refined Sugars
Refined Vegetable Oils
Vegetables
Fruits
Grains
Nuts, SeedsLegumes
Eggs
Dairy
Meats, Fish
Miscellaneous
Gerrior S, Bente I. 2002. Nutrient Content of the U.S. Food Supply, 1909-99: A Summary Report.U.S.D.A, Center for Nutrition Policy and Promotion. Home Economics Research Report No. 55
La discordancia
evolutiva
72 % son nutrientes que llevan con nosotrosmenos de 10.000 años
Bron: Cordain et al. Origins and evolution of the Western diet: health implications for the 21st century. Am.J.Clin.Nutr. 2005; 81:341-354.
Anti-nutrientes en la nutrición actualGluten, caseína cereales, leche Daña tight-junctions
Celiaquía, leaky gut
Lectinas, saponinas Cereales, legumbres mimicry molecularAutoinmunología, leaky gut, low grade inflammation
Fitatos Cereales, legumbres Impide absorciónDeficiencias (Fe, Zn, Mg, Ca, vit. B3)
Goitrogenes Soja, cacahuetes Iodo, T3, T4Hipotiroidismo, atrofía cerebral
Doerge et al. Goitrogenic and estrogenic activity of soy isoflavones.Environ Health Perspect. 2002 Jun;110 Suppl 3:349-53.
Gaitan E et al. Antithyroid effects in vivo and in vitro of babassu and mandioca: a staple food in goiter areas of Brazil. Eur J Endocrinol 1994 Aug;131(2):138-44
• 1. Certain saponin/ glycoalkaloidcontaining foods
• 2. Certain lectin containing foods
• 3. Gliadin (wheat protein)
• 4. Capsaicin containing peppers
• 5. Alcohol (Ethanol)
• 6. NSAIDS (aspirin, ibuprofen, naproxen)
• 7. Oral contraceptives
• 8. Antacids containing aluminum hydroxide (Alum) (tb en vacunas)
• 9. Factors causing E. coli & gram negataive overgrowth in gut (lectins)
Dietary Factors Known to Increase Intestinal Permeability
Intestinal homeostasis
Tsuji NM, Kosaka A. Oral tolerance: intestinal homeostasis and antigen‐specific regulatory T cells. Trends Immunol. 2008 Nov;29(11):532‐40.
Fresh FruitsFresh Veggies
Nuts/Seeds Fish/Seafood Lean Meats
HealthfulOils
Recommendations for a Contemporary Diet Based Upon Paleolithic Food Groups
Cordain L. Am J Clin Nutr. 2005
Nutrición Resoleomics• Crema de zanahoria con aceite de oliva macerado con tomillo,
romero, ajo y guindilla.– 4‐5 cebollas– 4‐6 dientes de ajo– 1‐2 puerros– 8‐10 zanahorias
• Pescado azul con salsa de cilantro• Carne biológica• Crucíferas: brócoli, col, coliflor, coles de bruselas,…• Curcuma• Manzana‐pera al horno con canela• Papaya, uva negra y frutos del bosque• cacao• Nueces y piñones• agua + zumo de limón
Terapia Ortomolecular Resoleomics
• Aceite omega 3 3 gr/día
• Aceite de hígado 40‐60 mcg vit D/día (analítica)
• Salix alba 1500 mgr (1‐1‐1) o Populus nigra– Fase aguda 30 gotas cada 4 horas– Fase subaguda30/30/30
• ¿Probiótico?
Óptimo vit. D
Cannell, Altern Med Rev 2008
D 012-0027 15.02.2005
Gracias por su atención
@CarlosRegenera
Carlos Pérez Ramirez
www.regenera.cat
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