Contenido - InfomedOct.- Dic. del 2002 Año 11 No. 4 COMITÉ EDITORIAL Presidenta Concepción Campa...

Oct.- Dic. del 2002 Año 11 No. 4

COMITÉ EDITORIAL

PresidentaConcepción Campa Huergo

VicepresidenteGustavo Sierra González

Editores EjecutivosOrlando Gutiérrez y Gilberto Sotolongo

AsesoresJuraj Ivanyi (UK) y Epifanio Selman (CU)

Editor Biología MolecularArmando Acosta

Editor InmunologíaArmando Cádiz

Editor MicrobiologíaIsabel Martínez

Editor EpidemiologíaJorge Menéndez

Editor TecnologíaArturo Talavera

Redactor JefeVirginia Betancourt

Corrección ReferenciasBertha Pimienta

TraducciónEloísa Le Riverend

Los artículos originales de estapublicación son arbitrados.

Se autoriza la reproducción de losmateriales originales publicados en esta

Revista, siempre que se indique suprocedencia.

El contenido de las informacionesaparecidas en esta Revista no expresa

necesariamente la opinión de laInstitución.

ISSN 1025-0298 (Versión Electrónica)

Calle 212 No. 3112 e/ 31 y 37, La Lisa.Ciudad de La Habana. Cuba.

Ap. 16017, Cod. 11600!!!! (53-7) 271 6557Fax: (53-7) 33 6754

E-mail: vaccimonitor@finlay.edu.cu Web: http://www.finlay.edu.cuhttp://www.sld.cu/instituciones/finlay/publicaciones/vaccimonitor/vm.htm

ontenidoontenidoontenidoontenido

Los inmunológos latinoamericanos se aprestan 6to Congreso de la Asociación Latinoamericana de Inmunefectuarse en el Palacio de Convenciones, La Habana, Cub9 y 13 de diciembre del presente año.

Este evento se ha concebido para que coincida con la3er Congreso Cubano de Inmunología, oportunidad proconocer sobre los avances en la investigación, tratamiende enfermedades en Cuba.

Se espera que profesionales provenientes de más de 40 pen este cónclave regional que contará también con prestigiosos especialistas de otras latitudes.

Por la importancia y la calidad científica de las contribucdebatirán, VacciMonitor ha considerado oportuno compilaespecial, los resúmenes de los trabajos que serán preseHavana 2002.

ORGANIZING COMMITTEE / COMITE ORGANIZADOR

Presidents / PresidentesJorge V. Gavilondo (Cuba; President / Presidente, ALAI); Gustavo Sierra (Cuba; E-mail: ALAI@finlay.edu.cu

Vicepresidents / VicepresidentesOliver Pérez (Cuba; General Secretary / Secretario General, ALAI, SCI); Clelia RieVice-president ALAI / Vice-presidente ALAI); Alberto Nieto (Uruguay; Past PresidPresidente Anterior ALAI)

Secretariat (alphabetical order) / Secretariado (orden alfabético)Reinaldo Acevedo; Marta Ayala (Treasurer ALAI / Tesorera ALAI); Julio Balboa; Bracho;Mónica Bequet; Osmir Cabrera; Judith M. del Campo; Maribel Cuello; Al(Conventions Center / Palacio de Convenciones); Danay Gil; Miriam Lastre (TreaTesorera SCI); Tamara Rodríguez; Caridad Román (Havanatur SA)

Support / AseguramientoCarlos Taboada Caridad Zayas Carlos Corcho

National Advisory Committee / Comité Asesor NacionalAgustín Lage; Carlos Silva; Antonio González-Griego; Catalino UstarizRuben RodConsuelo Macías; Sergio Arce; Alina Alerm; Luis Fonte;Jose L Fernández-Yero;MAlonso Gustavo Kourí; Jose M. Ballester;Rolando Pérez;Eduardo Pentón;Rosa Is

Regional and International Scientific Advisory Committee / Comité CieRegional e InternacionalFernando Goñi (Uruguay); Armando Peréz Puigbó (Venezuela); Alberto Nieto (UrOrtiz (Mexico); Marianna Newkirk (Canada); Ethel García Latorre; (México/MéxicLouis (WHO);Margarita Brizuela (Paraguay); Mohamed Daha (The Netherlands/HCarlos Aguillón (Chile);Josef Smolen (Austria); Arturo Ferreira (Chile); Genevieve(France/Francia); Jorge Allende (RELAB); Anders Orn (Sweden/Suecia); Livia LusFritz Melchers; Switzerland/Suiza); Carlos A. Fossati (Argentina); Ricardo CardoOscar Grau (RELAB); Luis F. García (Colombia); Rodrigo Correa de Oliveira (BrazPellegrini (PAHO/OPS); Jorge Kalil (Brazil); George das Reis (Brazil); Alejandro ALeopoldo Santos (Mexico/México); José A Chabalgoity (Uruguay); Harmut Peter(Germany/Alemania); Jacob Natvig (Norway); Clelia Riera (Argentina)

para asistir alología (ALAI), aa, entre los días

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RESÚMENES

PLENARY CONFERENCES

Gustavo Sierra (Cuba) First effective vaccine against B meningococcal disease based on aproteoliposome structure

Philippa Marrack (USA) The courtship between MHC and the T-cell receptor

Parallel Plenary Conferences (Tuesday 10, Morning)

Agustin Lage (Cuba) Immunoregulation and cancer: the hurdles of complexity (Room 3)

Louis Du Pasquier(Switzerland) Origin and evolution of the vertebrate immune system (Room 4)

Parallel Plenary Conferences (Tuesday 10, Afternoon)

Masayuki Miyasaka(Japan)

Molecular determinants controlling tissue-specific lymphocyte homing -dogmas and enigmas (Room 3)

Anders Örn (Sweden) Defining factors necessary to initiate and maintain chronic inflammatorydisorders in murine Chagas´ Disease (Room 4)

Parallel Plenary Conferences (Wednesday 11, Morning)

Jacques Louis(Switzerland)

The murine model of infection with L. major as a tool to study geneticdifferences in Th subset development (Room 3)

Marianna Newkirk(Canada)

The Rheumatoid Factor response in infection and autoimmunity (Room4)

Parallel Plenary Conferences (Wednesday 11, Afternoon)

Mohamed Daha (TheNetherlands)

Innate immunity and the complement system in autoimmune disease(Room 3)

Paul Kincade (USA) Identification of the earliest lymphocyte precursors in bone marrow ofmouse and man (Room 4)

Parallel Plenary Conferences (Thursday 12, Morning)

Nikolay Petrovsky(Australia) Temporal compartmentalisation of the immune response (Room 4)

Parallel Plenary Conferences (Thursday 12, Afternoon)

Jorge Kalil (Brazil) Immunopathology of rheumatic heart disease (Room 3)

Christopher Rudd (UK) Role of adaptors in TcR and co-receptor signaling (Room 4)

Parallel Plenary Conferences ( Friday 13, Morning)

Jorge V. Gavilondo(Cuba) Recombinant therapeutic antibodies (Room 3)

Lindsay Dent (Australia) Eosinophils in health and disease (Room 4)

Closing Keynote Address (Friday 13, Afternoon)

Henry Metzger (USA) Policy for science, science for policy

ORAL SESSIONSTUMOR IMMUNOLOGY AND IMMUNOTHERAPY

1. Nikolay Petrovsky (Australia) Computational modeling and prediction systems in clinical andexperimental immunology

2. W. H. Fridman (France) Tumor immunological microenvironment: prognostic and therapeuticvalue

3. Catherine Sautes-Fridman (France) Expression and biological roles of Fc gamma receptors inhuman metastatic melanoma

4. Luis E. Fernández (Cuba) Acetylated and glycolilated GM3 cancer vaccine: an update 5. Jose A. Chabalgoity (Uruguay) Designing new immunotherapies for cancer using liveattenuated salmonella as a vector for DNA vaccines

6. Laszlo Radvanyi (Aventis-Pasteur) New antigens and vectors for therapeutic vaccination againstbreast cancer and tumor angiogenesis

7. Ana M. Vázquez (Cuba) Evidences of an idiotypic network in the Neu Gc-containing gangliosidesystem: preclinical and clinical data

8. Cornelis Melief (The Netherlands) Precision guiding of cytotoxic T lymhocytes responses forcancer therap

9. Tania Crombet (Cuba) Epidermal growth factor based cancer vaccine for non-small cell lungcancer therapy: report from a phase I scale up trial

10. Flavio Salazar Onfray (Chile) Detection of anti melanoma specific CTL in PBMC from melanomapatients treated with autologous dendritic cells loaded with tumor cell extracts

11. Giselle Suárez (Cuba) Phase I clinical trial of the ganglioside cancer vaccine N-Acetyl-GM3/VSSP/Montanide ISA 51 in advanced breast cancer patients

12. Marie C. Bene (France) Immunophenotyping of leukemias 13. Gilbert C Faure (France) Tobacco exposure: local inflammation or acquired immune deficiency 14. Carlos Barbas III (USA) Chemical approaches to cancer therapeutics 15. James W. Larrick (USA) Novel approaches to reverse resistance to apoptosis in cancer 16. Mayra Ramos (Cuba) 99mTc labeled anti-human EGF receptor antibody (ior EGF/R3) in patientswith tumors of epithelial origin

17. Tania Crombet (Cuba) Use the anti EGF receptor antibody h-R3 in combination withradiotherapy in the treatment of advanced head and neck cancer

18. Pedro López-Saura (Cuba) Interferons and neoplasia in Cuba 19. AS Schanoski et al. (Brazil) WALKER 256 TUMOR MHC CLASS I EXPRESSION DURING THESHIFT FROM "A" VARIANT INTO THE IMMUNOGENIC "AR" VARIANT. SOP

20. L Alaniz et al. (Argentina) CD44-HYALURONIC ACID INTERACTION MODULATESMETALLOPROTEINASES IN A T CELL MURINE LYMPHOMA AND IN INFLAMMATORYLEUKOCYTES. SOP

21. MC Anazetti et al. (Brazil) TREATMENT OF LEUKEMIC CELLS (HL60) WITH DIMETHYLAMIDE-CROTONIN TRIGGERS APOPTOSIS DEPENDENT OF CASPASES -2 AND -9, BACTIVATION.SOP

IMMUNOLOGY OF PARASITE DISEASES

1. Manoel Barral Netto (Brazil) Immunology of human leishmaniasis 2. Genevieve Milon (France) Parasitism, a rapid and renewed cross talk between parasites and theimmune system of their hosts: the example of Leishmania spp.

3. Edgar Carvalho (Brazil) The role of host and parasite factors in the development of tegumentaryleishmaniasis

4. Aldina Barral (Brazil) Molecular epidemiology of human leishmaniasis: natural immune responsesagainst saliva proteins derived from the insect vector

5. CM Trujillo et al. (Colombia) CELL EXPRESSION OF COSTIMULATORY MOLECULES NODIFFERS IN PATIENTS WITH LOCALIZED CUTANEOUS LEISHMANIASIS AND ENDEMICALLY

EXPOSED ASYMPTOMATICS. SOP 6. S Télles et al. (Venezuela) EXPRESSION OF PEPTIDE-HLA COMPLEXES IN INFECTEDMACROPHAGES WITH Leishmania Braziliensis. SOP

7. H Goto et al. (Brazil) IMMUNOPATHOGENESIS OF GLOMERULONEPHRITIS IN VISCERALLEISHMANIASIS (VL) INVOLVES CD4+ T CELLS, IMMUNOGLOBULIN AND MODULATION OFAPOPTOSIS. SOP

8. Rose Leke (Cameroon) Malaria during pregnancy: diagnosis and immune responses 9. Arturo Ferreira (Chile) Trypanosoma cruzi Calreticulin: some immunomodulatory properties

10. A Ruiz Espinosa et al. (Cuba) CONSTRUCTION AND EVALUATION OF IMMUNOGENICITY ANDINDUCED PROTECTION IN BALB/C MICE IMMUNIZED WITH A GENOMIC LIBRARY OFEXPRESSION OF TRYPANOSOMA CRUZI. SOP

11. JC Sepulveda-Arias et al. (Colombia-Germany) STUDIES ABOUT IMMUNE RESPONSE IN RATSINFECTED WITH Toxoplasma gondii VIA MILK. SOP

12. A. Rodríguez et al. (Cuba) SIGNIFICANT PROTECTIVE EFFECTS OF NAKED DNA BASEDIMMUNIZATION FROM LETHAL TOXOPLASMOSIS IN MICE. SOP

13. Rodrigo Correa (Brazil) Mechanism of resistance and pathology in Schistosoma nansoniinfection

14. Miguel Stadecker (USA) Schystosomiasis: a helminthic disease caused and shaped by the hostsimmune response

15. David Pritchard (UK) The immunological challenge posed by human hookworm infections, andthe quest for vaccines

16. G Ferragut et al. (Uruguay) ROLE OF IL-4 IN EXPERIMENTAL INFECTION BY THE HELMINTHEchinococcus granulosus. SOP

17. A Olivos-García et al. (Mexico) AMEBIC CYSTEINE PROTEINASE 2 (EhCP2) PLAYS EITHER AMINOR OR NO ROLE IN TISSUE DAMAGE IN ACUTE EXPERIMENTAL AMEBIC LIVER ABSCESSIN HAMSTERS. SOP

18. Luis Fonte Galindo et al. (Colombia) INTESTINAL AMEBIASIS. IMMUNOLOGICAL ANDBIOMOLECULAR DEMONSTRATION OF THE OVERESTIMATION OF A HEALTH PROBLEM. SOP

19. M del P Jiménez et al. (Colombia) DIFFERENTIAL PHAGOCYTIC CAPACITY OF Nramp1 GENECONGENIC MACROPHAGE LINES TO THE INFECTION WITH CONIDIAS OF ParacoccidioidesBraziliensis. SOP

IMMUNOLOGY OF VIRAL DISEASES

1. Verena Muzio (Cuba) Hepatitis B prophylactic vaccines: realities and new perspectives 2. Eduardo Pentón (Cuba) Therapeutic vaccine approaches to Hepatitis B infection 3. Santiago Dueñas (Cuba) Development of therapeutic vaccines for Hepatitis C 4. Antonio González Griego (Cuba) Considerations on diagnostic, prognostic and prophylaxis-therapeutic intervention in Hepatitis type B

5. Hugo Nodarse (Cuba) Treatment of viral diseases with Interferon in Cuba 6. J Marante et al. (Cuba) IMPROVEMENT OF HCV-SPECIFIC IMMUNE RESPONSES USING ANEW VECTOR OF THE pMAE PLASMID SERIE. SOP

7. E Esquivel et al. (Mexico) ANALYSIS OF B AND T CELL ACTIVATION IN MESENTERIC LYMPHNODES FROM MICE INFECTED WITH ROTAVIRUS. SOP

8. Elopy Sibanda (Zimbabwe) HIV: diagnostic, clinic, and therapeutic aspects in Africa 9. Carlos Duarte (Cuba) Induction of a Th1, CTL mediated immune response against HIV-1chimeric proteins with DNA and poxviral vectors

10. Barbara Ensoli (Italy) Novel approaches for HIV/AIDS vaccine development: from basic scienceto human trials

11. D Vázquez-Blomquist et al. (Cuba) MODIFIED VACCINIA VIRUS ANKARA (MVA) PRIMING ANDFOWLPOX VIRUS BOOSTER ELICIT STRONGER CTL RESPONSE IN MICE AGAINST AN HIV-1EPITOPE THAN DNA-POXVIRUS PRIME-BOOST APPROACH. SOP

12. A Alvarez et al. (Cuba) VIRAL LOADS AND PHENOTYPIC MARKERS OF HIV PROGRESSION INCUBAN PATIENTS. SOP

13. E Iglesias et al. (Cuba) IMMUNIZATION WITH MAPs COUPLED TO CARRIERS: INFLUENCE OFTHE EPITOPIC DENSITY AND PRE-EXISTING IMMUNITY TO THE CARRIER. SOP

14. V Kourí et al. (Cuba) KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV)SEROPREVALENCE IN CUBAN POPULATIONS. SOP

15. Gustavo Kouri (Cuba) Dengue. Situation in Latin America and the Caribbean - 2002 16. Eric Martínez (Cuba) Pathogenesis of Dengue Hemorrhagic Fever 17. Guadalupe Guzmán (Cuba) Dengue vaccines, advances and challenges 18. G Mellado Sánchez et al. (Mexico) EVALUATION OF IMMUNE RESPONSE OF INFECTEDDENGUE PATIENTS TO RECOMBINANT NS1 AND E PROTEINS. SOP

19. MMB Moreno-Altamirano et al. (Mexico) GENE EXPRESSION IN HUMAN MACROPHAGESINFECTED WITH DENGUE VIRUS. SOP

20. AB Pérez et al. (Cuba-EEUU) SERUM LEVELS OF IL-12, IL-10, RANTES AND NITRIC OXIDE INDENGUE VIRUS INFECTED PATIENTS. SOP

21. B Sierra et al. (Cuba) THE RECOMBINANT DEN 2 ENVELOPE B DOMAIN ELICITS A STRONGSEROTYPE SPECIFIC LYMPHOPROLIFERATIVE RESPONSE IN MICE. SOP

IMMUNOLOGY OF BACTERIAL DISEASES

1. Stitaya Sirisinha (Thailand) Dendritic cell maturation and cytokine production induced byBurkholderia (pseudomonas) pseudomallei

2. Narinder Mehra (India) Cytokine polarization in mycobacterial infections: MHC influences3. Stanley Ress (South Africa) Immune response to neonatal BCG vaccination4. David Pritchard (UK) Immune modulation by bacterial quorum sensing molecules, and their

application to immunological disease5. Vincent Wilson (UK) Further studies on the acute effect of bacterial 'quorum-sensing'

molecules on porcine coronary arteries6. Narinder Mehra (India) Extreme MHC diversity and its implications on vaccination protocols7. R Pellegrino et al. (Uruguay) MrpA FIMBRIAL PROTEIN AS A PROTECTIVE ANTIGEN AGAINST

URINARY TRACT INFECTIONS. SOP8. Dietrich Kabelitz (Germany) Role of human gamma delta T lymphocytes in disease9. Vincent Wilson (UK) FMLP produces vasoactive effects in human and porcine blood vessels10. Oliver Pérez (Cuba) Immunological response induced by relevant protective bacterial antigens11. Marta González (Cuba) Immunogenicity, potency, and safety of an adsorbed trivalent

Leptospira vaccine12. Luis García (Cuba) Advances in the research of Cuban Cholera vaccine13. Luis Riverón (Cuba) Vi polysaccharide typhoid vaccine14. Luis F. García (Colombia) Consequences of Mycobacterium tuberculosis (Mtb) infection on

macrophage functions15. Idrián García (Cuba) Use of recombinant human interferon gamma in patients with multidrug-

resistant tuberculosis16. Armando Acosta (Cuba) New strategies for tuberculosis vaccine development17. D Gil et al. (Colombia) MYCOBACTERIAL-INDUCED NECROSIS AND APOPTOSIS IN

MACROPHAGES FROM PATIENTS WITH TUBERCULOSIS (TB) AND HEALTHY CONTROLSDEPEND ON TNF-alfa/IL-10 BALANCE. SOP

18. B Rivas-Santiago et al (Mexico-USA). INDUCTION OF HUMAN b-DEFENSIN 2 mRNAEXPRESSION BY MYCOBACTERIUM TUBERCULOSIS IN A HUMAN LUNG EPITHELIAL CELLLINE. SOP

19. B Ortiz et al. (Colombia). ROLE OF CD14, MANNOSE RECEPTOR (MMR), SCAVENGERRECEPTOR (ScR) AND TOLL-LIKE RECEPTOR 2 (TLR2) IN Mycobacterium tuberculosis-INDUCED MACROPHAGE APOPTOSIS. SOP

20. AVE Capozzo et al. (Argentina) DEVELOPMENT OF GENETIC VACCINES AGAINST HEMOLYTIC

UREMIC SYNDROME (HUS). SOP21. Sandra Bajaña-Miranda et al. (Mexico). CUTANEOUS LANGERHANS DENDRITIC CELLS AND gd

T CELLS IN A MURINE MODEL OF LEPROSY: IN VIVO ANALYSIS. SOP22. RM Salazar González et al. (Mexico). EVALUATION OF THE IMMUNE RESPONSE TO PORINS

FROM Salmonella typhi IN HUMANS. PHASE 1 STUDY. VACCINE AGAINST TYPHOID FEVER.SOP

23. M Lastre et al. (Cuba-Italy). NEUTROPHILS IN THE INDUCTION OF IMMUNE RESPONSE ANDEFFECTOR CELA MENINGITIDIS B. SOP

ADJUVANTS

1. Johan Hoebeke (France) What can we learn from the structure of antibody-peptide complexes? 2. Wolfram Metzger (Germany) Attenuated Salmonella as carriers for an anti Helicobacter vaccinein mouse and man

3. José A López (Australia) Optimising a blood DC preparation for immunotherapy 4. Gerardo E Guillén (Cuba) Immunologic evaluation of a DTP-HB vaccine formulation for nasaladministration

5. Jim Koropatnick (Canada) Metallothionein and innate activation of primary human and mousemonocytes

6. Osmir Cabrera (Cuba) Conjugation as a possible solution to antigens with low immunogenicity

IMMUNODEFICIENCIES

1. Harmut Peter (Germany) Common variable immunodeficiency: a new classification andmolecular definition of new subsets

2. Teresa Español (Spain) Diagnosis of the molecular defects causing primary immunodeficiencydiseases

3. Ricardo Sorensen (Argentina) Specific antibody deficiencies: implications for the developmentof the humoral immune system

4. Oscar Porras (Costa Rica) MHC class II deficiency 5. Julia Palma (Chile) Pediatric Hematopoyetic Stem Cell Transplantation (HSCT) in primaryimmunodeficiency diseases

6. Teresa Español (Spain) Update on therapy for primary immunodeficiency diseases

IMMUNOLOGY AND REPRODUCTION

1. Petra Clara Arck (Germany) Immunobiology of implantation and occult pregnancy loss 2. Ricardo A. Margni (Argentina) Asymmetric antibodies: role in the maintenance of a non-conflictive mother-fetus relation

3. Gerard Chaouat (France) Cytokines in pregnancy and implantation/early abortion: re-examiningthe Th1/Th2 paradigm

4. Ana Claudia Zenclussen (Argentina) Introducing a novel mouse model for pre-eclampsia 5. Li via Lustig (Argentina) Immunoregulation and autoimmunity of the testis: pathogenesis ofexperimental autoimmune orchitis

6. J Puente et al. (Chile) FUNCTIONAL AND PHENOTYPIC RESPONSE OF THE HUMAN NK CELLSIN NORMAL AND PATHOLOGICAL PREGNANCY. SOP

AUTOIMMUNITY AND AUTOIMMUNE DISEASES

1. Jorge Kalil (Brazil) Antigen recognition and trimolecular complex in post-infectious autoimmunedisease

2. Eli Sercarz (USA) Public, drived T cell clones as the cause of autoimmunity in EAE and IDDM 3. Xian-hao Xu (China) Recent advances of study on Myasthenia Gravis in China 4. Ethel García Latorre (Mexico) Process and presentation of the rHSP60 from Klebsiellapneumoniae in ankylosing spondylitis

5. Johan Hoebecke (France) Autoantibodies against G protein coupled cardiovascular receptors:how do they interfere with receptor function?

6. F Zambrano-Zaragoza et al. (Mexico) RECOGNITION OF THE 117-125 PEPTIDE OF THE HSP60FROM Klebsiella pneumoniae BY CD8 T CELLS FROM ANKYLOSING SPONDYLITIS PATIENTS.SOP

7. F González et al. (Chile) THE -308 POLYMORPHISM IN THE PROMOTER REGION OF TUMORNECROSIS FACTOR GENE AND EX VIVO LIPOPOLYSACCHARIDE-INDUCED TNF EXPRESSIONIN PATIENTS WITH AGGRESSIVE PERIODONTITIS AND/OR TYPE 1 DIABETES MELLITUS. SOP

8. Moncef Zouali (France) Immune receptor signaling and autoimmunity 9. Enrique Montero (Cuba) Therapeutic immunosuppression and immunodiagnosis of autoimmunediseases based on an anti-CD6 monoclonal antibody

10. Nikolai Petrovsky (Australia) Pathogenesis of type 1 diabetes: dominant pathway of beta cellapoptosis and prevention of immune mediated beta cell destruction

11. Clelia M. Riera (Argentina) Experimental autoimmune prostatitis: a model of chronic nonbacterium human prostatitis?

12. Constantin Bona (USA) Molecular and genetic studies on the role of IL-4 in fibrosis 13. X Hernández et al. (Cuba) EVALUATION OF THE TOXICITY OF THE HUMANIZEDMONOCLONAL ANTIBODY T1HT IN PATIENTS WITH RHEUMATOID ARTHRITIS. SOP

14. M Sospedra et al. (Spain-USA) UNBIASED IDENTIFICATION OF ANTIGEN SPECIFICITIES OFCEREBROSPINAL FLUID-INFIL MULTIPLE SCLEROSIS. SOP

SIGNAL TRANSDUCTION - CELL INTERACTIONS

1. Hannes Stockinger (Austria) Membrane microdomains in signal transduction of immune cells 2. Mario Rosemblatt (Chile) Dendritic cells as regulators of lymphocyte homing 3. Henry Metzger (USA) Quantitative analysis of signal transduction 4. Leopoldo Santos (Mexico) CD38 uses the classical signal transduction pathway PLC-gamma 2,pKC, and nF-kB to induce survival and proliferation of mature B cells

5. John Kappler (USA) The role of Bcl-2 related proteins in T-cell death 6. Carlos Rosales (Mexico) PI 3-K and ERK are recruited for Fc receptor-mediated phagocytosisduring monocyte-to-macrophage differentiation.

ANTIGEN PRESENTATION - TRANSPLANTATION

1. Laurence Boumsell (France) International workshops and conferences on CD molecules: past,present, and future

2. Nelson Fernández (UK) Models of cell surface expression of MHC Class II and its importance inthe immunological synapse

3. Cristina Cuturi (France) Regulatory cells and tolerance in transplantation 4. Ignacio Anegón (France) Costimulatory blockade and tolerance in allotransplantation using genetransfer

5. Josef Brock (Germany) Alloreactive EGFP-engineered T lymphocytes in a rat kidneytransplantation model

6. D Sauma et al. (Chile) THE DECREASE ON T CELL COUNTS AFTER A SINGLE DOSE OFIMMUNOSUPPRESSIVE DRUGS IN RENAL TRANSPLANT PATIENTS CAN BE ASCRIBED TO ALOW DOSE OF PREDNISONE. SOP

IMMUNOLOGY OF ALLERGIC DISEASES

1. Rudolf Valenta (Austria) Recombinant allergen-based strategies for diagnosis and therapy ofIgE-mediated allergies

2. Momtchilo Russo (Brazil) Oral tolerance prevents the development of airway hyperactivity andTh2-associated allergic responses in prototypic murine models of experimental asthma

3. Ruben Rodriguez-Gavalda (Cuba) Natural history, treatment, and management of childhoodasthma

4. Alina Alerm (Cuba) Immune response against vaccine antigens in asthmatic patients 5. Sabine Flicker (Austria). A grass polen allergen-specific human IgE antibody recognizingimmunoglobulin-like domains

6. Alexis Labrada (Cuba-Colombia) Characterization of rBlo t 13, recombinant allergen from Blomiatropicalis using monoclonal antibodies.

7. TG Naidu et al. (Brazil) A COMPARATIVE EVALUATION OF SERUM EOSINOPHIL CATIONICPROTEIN (S-ECP) AND TOTAL BLOOD IgE AS DIAGNOSTIC PARAMETERS IN PEDIATRICASTHMA. SOP

8. L. Calderón et al. (Cuba) LIPOSOME ENCAPSULATION OF THE MAJOR ALLERGENS OFDermatophagoides siboney FOR SPECIFIC IMMUNOTHERAPY. SOP

9. JL Aguilar Olano et al. (Peru). ETIOPATHOGENIC ROLE OF FUME OF FISH'S FLOURFACTORIES IN THE DEVELOPMENT OF ALERGIC MANIFESTATIONS BY CHILDRENACHANCAY, LIMA, PERU. SOP

IMMUMUNOTECHNOLOGY

1. Luis Javier González (Cuba) Advances in proteome technology 2. James W. Larrick (USA) New approaches for design of gene chips 3. Angel Oñate (Chile) DNA vaccine in Brucella abortus 4. Alexei Licea (Mexico) Anti-idiotypic chimeric antibodies as an anti-scorpion toxin vaccine 5. Alexei Licea (Mexico) Shark chimeric antibodies 6. Cristina Mateo (Cuba) A new method to reduce immunogenicity of chimeric monoclonalantibodies

7. Gertrudis Rojas (Cuba) Phage display libraries as sources of human antibodies: from basics toclinics

8. Gregg Silverman (USA) Phage-display engineering of magic bullets for induction of in vivo VHtargeted apoptotic deletion of B-cells in mice and non human primates

9. James W. Larrick (USA) Taczyme: a new means to generate and affinity mature antibodies 10. Merardo Pujol (Cuba) Tobacco as a model plant for recombinant antibody expression

11. Rodolfo Valdés et al. (Cuba) IMMUNOPURIFICATION OF THE HEPATITIS B SURFACE ANTIGENUSING A PLANT-DERIVED HBsAg-SPECIFIC ANTIBODY. SOP

12. O Gires et al. (Germany) DIRECT IDENTIFICATION OF TUMOR ANTIGENS BY AUTOLOGOUSANTIBODY SCREENING. SOP

13. P Vargas et al. (Chile) DENDRITIC CELL IMMUNIZATION IMPROVES PRODUCTION OFMONOCLONAL ANTIBODIES AGAINST THE REGULATOR OF MHC CLASS II EXPRESSION(CIITA). SOP

CYTOKINES - INFLAMATION

1. Juan C. Aguillón (Chile) Genetic polymorphism of cytokines: implications on susceptibility orresistance to diseases

2. Sergio Romagnani (Italy) Pleiomorphic role of CXCR3 and its ligands 3. Ralf Schumann (Germany) Pathogen-associated molecular patterns (PAMPs) and the host'sinnate immune recognition system

4. Douglas Golenbock (USA) Lessons from Drosophila: the LPS receptor 5. Manuel Araña (Cuba) Anti LPS peptides and cytokine regulation in sepsis 6. Horacio Serra (Argentina) SLC (CCL21): much more than a constitutive chemokine 7. M Kurte et al. (Chile) A SYNTHETIC PEPTIDE HOMOLOGOUS TO THE FUNCTIONAL DOMAINOF HUMAN INTERLEUKIN 10 DOWNREGULATES THE EXPRESSION OF THE MHC CLASS I

ALPHA CHAIN AND TAP 1/2 IN HUMAN MELANOMA CELLS. SOP 8. John Hiscott (Canada) IFN and NF-kB signaling pathways and the regulation of innate immunity 9. Silvio Perea (Cuba) Abrogation of the interferon (IFN) signaling pathways by humanpapillomavirus (HPV) type-16

10. Celia Fernandez (Cuba) NF-kB down regulation is a common target for the inhibition of TNFproduction and HIV replication by the DLE

11. Pedro Porrero (Cuba) Interferon-alpha in nervous system disorders 12. P A Rojas et al. (Peru-Germany) EFFECT OF AN EXTRACT OF Uncaria tomentosa (UÑA DEGATO) ON THE PRODUCTION OF THE TUMORAL NECROSIS FACTOR - ALPHA IN A MODELIN VIVO AND ITS ACTION LIKE AN ANTI-INFLAMMATORY AGENT IN VITRO. SOP

IMMUNODIAGNOSTICS

1. Rene Robaina (Cuba) Creating a sustainable diagnostic network with national scope: the caseof the SUMA system in Cuba

2. Luis Sorell (Cuba) Immunodiagnosis of celiac disease using fast visual tests 3. Mercedes Lopez (Chile) Immunohistochemical diagnosis of uveal malignant melanoma usingMelanocortin 1 Receptor (MC1R) specific antibodies

4. Anselmo Otero (Cuba) Immunoanalytic tools for the evaluation of enzymatic function. AcatELISA for detection of HIV protease inhibitors.

5. B Velázquez et al. (Uruguay) OPTIMIZATION OF RECOMBINANT STREPTOLYSIN-OEXPRESSION AND ANALYSIS OF FINAL PRODUCT FORMULATIONS SUITABLE FORIMMUNODIAGNOSIS. SOP

6. M Hernández et al. (Cuba) CHIMERIC SYNTHETIC PEPTIDES CONTAINING TWOIMMUNODOMINANT EPITOPES FROM THE GAG P19 PROTEIN AND THE ENVELOPE GP46GLYCOPROTEIN FOR THE IMMUNODIAGNOSIS OF HTLV-II VIRUS INFECTION. SOP

7. RA Rivero et al. (Cuba) MOUSE MONOCLONAL ANTIBODIES AGAINST ABO BLOOD GROUPANTIGENS IN CUBA: ITS EVALUATION IN THE 4TH INTERNATIONAL WORKSHOP. SOP

8. C Macías et al. (Cuba) ENDOTHELIAL ADHESION MOLECULES ICAM-1, VCAM-1 AND E-SELECTIN IN PATIENTS WITH ACUTE CORONARY SYNDROME. SOP

VETERINARY IMMUNOLOGY

1. Manuel Rodriguez (Cuba) The Cuban experience in the control of Boophilus spp. by the anti-tickvaccine GavacTM

2. Patricia Zamorano (Argentina) Bovine herpes virus protein from plants infected withrecombinant tobacco mosaic virus possesses authentic antigenicity

3. A Soutullo et al. (Argentina) IMMUNE RESPONSE OF THE EQUINE INFECTIOUS ANEMIADISEASE VIRAL GP 45 PROTEIN TO A SYNTHETIC PEPTIDE IN MICE. SOP

4. TA. Cruz (Mexico) APOPTOSIS IN LUNGS OF PIGS INTRATRACHEALLY INOCULATED withMycoplasma hyopneumoniae. SOP

5. J. Casas et al. (Mexico) COMPARATIVE STUDY OF THE IMMUNE RESPONSE OF FIVEDIFFERENT SPECIES OF TILAPIA (Oreochromis). SOP

6. R Rivers et al. (Chile) DNA VECTORS FOR Brucella abortus. SOP 7. TG Naidu. (Brazil) LYSOSOMAL DEGRANULATION IN POLYMORPHONUCLEAR NEUTROPHILS:A NOVEL MECHANISM OF SURVIVAL OF PATHOGENIC b-HEMOLYTIC Staphylococcus aureusIN THE BOVINE MAMMARY GLAND. SOP

8. AP West Jr, PJ Bjorkman. (USA) CLONING AND CHARACTERIZATION OF THE CHICKEN YOLKSAC IGY RECEPTOR. SOP

POSTER SESSIONSIMMUNOLOGY OF BACTERIAL DISEASES I

1. HLA CLASS II GENES POLIMORPHISMS IN DRUG SENSITIVE AND DRUG RESISTANTPULMONARY TUBERCULOSIS IN MEXICANS PATIENTS. A Camarena Olvera, A JuárezCisneros, A Aquino Gálvez, D Castillo Sánchez, R Falfán Valencia. (MEXICO).ang_edco@yahoo.com.mx.

2 2. DEVELOPMENT OF GENETIC VACCINES AGAINST HEMOLYTIC UREMIC SYNDROME (HUS).AVE Capozzo, C Ibarra, V Pistone Creydt, G Dran, G Fernández, M Isturiz, MS Palermo.(ARGENTINA). alejavicca@yahoo.com.ar

3 3. TNFa, IFNg AND IL-10 GENE POLYMORPHISMS AND CYTOKINE PRODUCCION IN PATIENTSWITH TUBERCULOSIS (TB) AND HEALTHY CONTROLS. M Henao, S París, L F García.(COLOMBIA) marcelaisabel@yahoo.com

4 4. HIGH LEVELS OF NITRIC OXIDE CORRELATES WITH MYCOBACTERIUM TUBERCULOSISINHIBITION OF IFNg-INDUCED MHC CLASS II EXPRESION IN MURINE MACROPHAGES. JLJaramillo, GM Vásquez, LF García, LF Barrera. (COLOMBIA). fbarrera@quimbaya.udea.edu.co

5. EXPRESSION OF TOLL-LIKE RECEPTOR 2 (TLR2) IN DIFFERENT CIRCULATING CELLPOPULATIONS AND COMPARISON OF CD14+TLR2+ BLOOD MONOCYTES IN PATIENTSWITH TUBERCULOSIS AND HEALTHY CONTROLS. MC Ruiz, M Rojas, LF García. (COLOMBIA).rrcaro@epm.net.co

6. MONOCYTES AND NEUTROPHILS FROM TUBERCULOSIS PATIENTS ARE INSENSITIVE TOANTI-INFLAMMATORY EFFECTS TRIGGERED BY A PROTOTYPIC N-FORMYL PEPTIDE (FMLP).M Beigier-Bompadre, M Alemán, P Barrionuevo, MC Franco, CJ Rubel, MS Palermo, E Abbate,MC Sasiain, MA Isturiz. (ARGENTINA). mbeigier@yahoo.com

7 7. ROLE OF POLYMORPHISMS OF THE CD14 GENE PROMOTER IN TUBERCULOSIS. C Fonseca, EPacheco, L Garcia, M Arias. (COLOMBIA) marias@medicina.udea.edu.co

8 8. MODULATION OF SCAVENGER RECEPTORS (ScR) IN MONOCYTES FROM HEALTHYCONTROLS AND PATIENTS WITH TUBERCULOSIS (TB) BY MYCOBACTERIAL DERIVATIVES.LG León, M Rojas, LF García. (COLOMBIA) mrojasl@epm.net.co

9 9. BYSTANDER MACROPHAGES REMOVE Mycobacterium tuberculosis-INFECTEDMACROPHAGES AND INHIBIT THE INTRACELLULAR GROWTH OF Mycobacteriumtuberculosis. LG León, M Rojas, LF García. (COLOMBIA) mrojasl@epm.net.co

10. ROLE OF CD14, MANNOSE RECEPTOR (MMR), SCAVENGER RECEPTOR (ScR) AND TOLL-LIKERECEPTOR 2 (TLR2) IN Mycobacterium tuberculosis-INDUCED MACROPHAGE APOPTOSIS. BOrtiz, M Rojas, LF García. (COLOMBIA) mrojasl@epm.net.co

11. SPECIFIC PROLIFERATION OF CD4+ AND CD8+ T CELLS AGAINST Brucella abortus RB51ANTIGEN. M C Moreno-Lafont, V Paredes-Cervantes, A Estrada-Aguilera, R López-Santiago.(MEXICO). mlafont@encb.ipn.mx

12. EPIDEMIOLOGY OF MUCOCUTANEOUS INFECTIONS IN THE RECURRENT INFECTIONSYNDROME. JC Orrego, CJ Montoya, RD Gómez, PJ Patiño G., ME Vargas, JL Franco R., DGarcía de O., JC Wolf. (COLOMBIA)

13. MrpA FIMBRIAL PROTEIN AS A PROTECTIVE ANTIGEN AGAINST URINARY TRACTINFECTIONS. R Pellegrino, P Scavone, U Galvalisi,V Sosa, L Geymonat, P Zunino. (URUGUAY).rafael@iibce.edu.uy

4 14. MODULATION OF MYCOBACTERIAL-INDUCED MACROPHAGE APOPTOSIS BY ANTI-MYCOBACTERIAL DRUGS. D Gil, LF García, M. Rojas. (COLOMBIA). mrojasl@epm.net.co PDF

15. MYCOBACTERIAL-INDUCED NECROSIS AND APOPTOSIS IN MACROPHAGES FROMPATIENTS WITH TUBERCULOSIS (TB) AND HEALTHY CONTROLS DEPEND ON TNF-alfa/IL-10BALANCE. D Gil, LG León, LF García, M Rojas. (COLOMBIA). dipagil@medicina.udea.edu.co

16. EVALUATION OF THE IMMUNE RESPONSE TO PORINS FROM Salmonella typhi IN HUMANS.PHASE 1 STUDY. VACCINE AGAINST TYPHOID FEVER. RM Salazar González, MC MaldonadoBernal, NE Ramirez, J Beltrán Nava, C Tello Winniczuk, M Carrera Camargo, C López Macias, AIsibasi. (MEXICO). rsalg@yahoo.com

17. SALIVARY LEVELS OF IgA AND Streptococcus mutans IN PRE-AMAZONIC BRAZILIANPREGNANT WOMEN. R R Maya, M V V Lima, J E Batista , R N M Guerra. (BRAZIL/BRASIL).rguerra@elo.com.br

18. OPTIMIZATION OF PRECLINICAL IMMUNIZATION WITH OUTER MEMBRANE VESICLESVACCINE. G Bracho, S Cabezas, J del Campo, M Lastre, T Rodríguez, C Zayas, G Sierra, OPérez. (CUBA). gbracho@finlay.edu.cu

19. ENDOGENOUS GLUCOCORTICOID (GC) MODULATE NEUTROPHIL (PMN) FUNCTION IN AMURINE MODEL OF HEMOLYTIC UREMIC SYNDROME (HUS). S Gómez, G Fernández , CRubel, F Alves Rosa, P Barrionuevo, MA Isturiz, MS Palermo. (ARGENTINA).gomezs1015@yahoo.com.ar

20. NEUTROPHILS IN THE INDUCTION OF IMMUNE RESPONSE AND EFFECTOR CELL AGAINSTNEISSERIA MENINGITIDIS B. M Lastre, J Lapinet, G Bracho, C Zayas, M Díaz, G Sierra, MACassatella, and O Pérez. (CUBA-ITALY) mlastre@finlay.edu.cu

2 21. CROSS-REACTIVE ACTIVITY OF ANTIMENINGOCOCCAL HUMAN IMMUNOGLOBULINAGAINST DIFFERENT NEISSERIA MENINGITIDES GROUP B SEROTYPES. BalboaJA, et al.(Cuba). jbalboa@finlay.edu.cu

22. MYCOBACTERIAL ACYL-O-TREHALOSES MODULATE HUMAN T-CELL RESPONSES IN VITRO.R Saavedra, P Lezama, R Leyva, E Segura, LM López Marín. (MEXICO).saavedra@servidor.unam.mx

23. EFFECT OF THE SPLENIC DIALIZABLE EXTRACT (SDE) ON MURINE EXPERIMENTALTUBERCULOSIS, ASSESSED BY DIFFERENTIAL DISPLAY. M Pérez-Tapia, R Ramos-Payán, AFabre-Ruíz, J Rangel-Moreno, R Hernández-Pando, I Estrada-G, S Estrada-Parra S. (MEXICO).maypet@hotmail.com

24. CD28, CD80 AND CD86 EXPRESSION IN SKIN CELLS OF LEPROMATOUS AND TUBERCULOIDLEPROSY PATIENTS. S Navarro, C Guerrero, M Corrales, R López, M Fafutis. (MEXICO).celiagv2001@yahoo.com.mx

25. INDUCTION OF HUMAN b-DEFENSIN 2 mRNA EXPRESSION BY MYCOBACTERIUMTUBERCULOSIS IN A HUMAN LUNG EPITHELIAL CELL LINE. B Rivas-Santiago, C Sarabia, SSchwander, G Diamond, E Sada. (MEXICO-USA/MEXICO-EEUU). rondo_vm@yahoo.com

26. CD8+ T CELLS IMPROVE GROWTH INHIBITION OF MYCOBACTERIUM TUBERCULOSIS (MTB)H37RV IN HUMAN ALVEOLAR MACROPHAGES INFECTED IN VITRO. C Carranza, E Juárez, RHernández, C. Sarabia, K Bobadilla, D Escobedo, J Ellner, E Sada, S Schwander. (MEXICO-USA/MEXICO-EEUU). carranza_1999@yahoo.com

27. MEMORY ANTIBODY RESPONSE AND BACTERICIDAL ACTIVITY INDUCED BY PORINS FROMSalmonella enterica SEROVAR Typhi. I Secundino, L Cervantes, J Beltran, R Salazar, CMaldonado, A Isibasi, C López-Macias. (MEXICO). isibasi@prodigy.net.mx

28. DIFFERENTIAL PATTERN OF MITOCHONDRIAL MEMBRANE POTENTIAL (DYm) AndCYTOSOLIC CYTOCHROME C In M. tuberculosis H37Ra- AND H37Rv-INFECTEDMACROPHAGES. E Abarca-Rojano, P. Rosas-Medina, P Zamudio-Cortéz , R Mondragón-Flores,FJ Sánchez-García. (MEXICO). fsanchez@bios.encb.ipn.mx

29. CELL SIGNALING OF MYCOBACTERIAL-INDUCED MACROPHAGE APOPTOSIS. M Rojas, LFGarcía, M Olivier, B Ortiz, D Gil, LG León. (COLOMBIA-CANADA). mrojasl@epm.net.co

30. M. tuberculosis CULTURE FILTRATE PROTEINS INDUCE CD95 RELATED APOPTOSIS ONMONOCYTES OF THE THP-1 LINE. R. Mancilla, G. Bernal, P. Espinosa-Cueto, H. Díaz-Silvestre,M.A. Esparza-Cerón, M. Colón-González. (MEXICO) mancilla@servidor.unam.mx

3 31. THE 19 kDa GLYCOLIPOPROTEIN OF Mycobacterium tuberculosis IS A MAJOR ADHESIN FORTHP-1 AND MONOCYTE DERIVED-HUMAN MACROPHAGES. H. Díaz-Silvestre, P. Espinosa-Cueto, G. Bernal, C. Espitia, and R. Mancilla. (MEXICO) hugo@biomedicas.unam.mx

32. EFFECTS OF MYCOBACTERIAL LIPIDS ON PLEURAL MONONUCLEAR CELLS AND OFPETIVERIA ALLIACEA EXTRACT ON RESPONSE TO BCG IN THE PLEURAL CAVITY. V Cabral,A Rodrigues, E Abi-chacra, E Rodrigues, A Moura. (BRAZIL). cmoura@uerj.br

33. T-CELL PROLIFERATION AND IL-2 LEVELS IN YOUNG HEALTHY HOUSEHOLD CONTACTS OFLEPROMATOUS LEPROSY PATIENTS. M. Pita, A. Santerre, G. Zaitseva, A. Islas. (MEXICO).mpita@cucba.udg.mx

34. THE AP-1 TRANSCRIPTION FACTOR IS PRESENT IN LYMPHOCYTES FROM LL PATIENTS. Ma.R. Huizar, A. Santerre, V. Madrid , O. Peralta , A.E. Islas. (MEXICO). mhuizarl@yahoo.com.mx

35. MEMORY RESPONSE GENERATED IN AFRICAN GREEN MONKEYS AGAINSTPOLYSACCHARIDE C CONJUGATE. Carmenate T, Guirola M, Álvarez A, Caballero E, GonzálezS, Menéndez T, Canaán-Haden L, Guillen G. (CUBA). Anabel.alvarez@cigb.edu.cu

36. COMPARISON OF THE IMMUNE RESPONSE IN MICE AGAINST MENINGOCOCCAL GROUP CPOLYSACCHARIDES CONJUGATE TO THREE CARRIER PROTEINS. Alvarez A, Canaan-HadenL, Carmenate T, Menendez T, Delgado D, Rodes L, Silva R, Guillén G. (CUBA).Anabel.alvarez@cigb.edu.cu

37. IMMUNOGENICITY AND PROTECTIVE CAPACITY OF LEPTOSPIRA INTERROGANSSEROGROUP BALLUM KILLED WHOLE CELL ADJUVANTED VACCINES IN HAMSTERS. AGonzález, Y Rodríguez, Y Valdés, N Batista, JF. Nuñez, JF. Infante, M González. (CUBA).andresglez@finlay.edu.cu

38. IMMUNOGLOBULIN PREPARATION AGAINST LPS OF PSEUDOMONAS AERUGINOSASEROTYPE O11. A Moya, L Joó, A Rodrígruez, J Hernández Machín, J Hernández, JFAlmenares, D Berrios, Z Rodríguez, A Cádiz, SC Esnard. (CUBA). amoya@finlay.edu.cu

39. EVALUATION OF THE SPECIFIC HUMORAL IMMUNE RESPONSE IN MICE IMMUNIZED WITHAN EXPRESSION GENOMIC LIBRARY OF MYCOBACTERIUM TUBERCULOSIS. A Acosta, ZDíaz, K Hernández, ME Sarmiento, JL Leiva, M Martínez, M Fariñas, JF Infante , G Sierra .(CUBA). aracosta@finlay.edu.cu

40. EVALUATION OF THE EFFECT OF THE ADMINISTRATION OF HUMAN GAMMAGLOBULINS INA MODEL OF INFECTION WITH BCG IN MICE. A Acosta, N Olivares, A León, Y López, MESarmiento, A Cádiz, A Moya, G Falero, JF Infante, M Martínez , G Sierra . (CUBA).aracosta@finlay.edu.cu

4 41. THE VIABILITY AND THE COLONIZATION CAPACITY OF VACCINAL FORMULATION OFATTENUATED STRAIN 638 (VIBRIO CHOLERAE ). A Talavera, T Moreira, G Año, B Cedré, HDelgado, H García, L García. (CUBA). atalavera@finlay.edu.cu

42. ANTIGENICITY AND IMMUNOGENICITY OF INACTIVATED Vibrio cholerae STRAIN. G Año, HGarcía, T Valmaseda, B Cedré, Y Pino, O Ancheta, JL Pérez, L García, A Talavera. (CUBA).gano@finlay.edu.cu

43. PURIFICATION AND CHARACTERIZATION OF LIPOPOLYSACCHARIDE OF DIFFERENTSEROTYPES FROM PSEUDOMONAS AERUGINOSA. CLINICAL APPLICATIONS. JonatanHernandez, Sara C. Esnard, Aniel Moya, Hilda García, Barbará Cedré, Juan Almenares, AnaCallis, Vismak Torres, Jacqueline Alonso, Armando Cadiz, Gustavo Sierra.(CUBA).jhernandez@finlay.edu.cu

44. SAFETY AND IMMUNOGENICITY OF A SINGLE DOSE OF LIVE ATTENUATED ORAL CHOLERAVACCINE STRAIN 638, IN ECUADOR. H García, J Menéndez, L Shinkarenko, L E Plaza, LIzquierdo, Barbara Cedré, Tania Valmaseda, Y Pino, J L Pérez, G Año, L García, R Fando, ATalavera, G Sierra (CUBA). hgarcia@finlay.edu.cu

45. INHIBITION OF ANTICOLONIZING EFFECT OF POSITIVE SERUM FROM HUMANS INOCULATEDWITH THE ATTENUATED STRAIN 638 VIBRIO CHOLERAE O1. JL. Pérez, Y Pino, T Valmaseda,G Año, B Cedré, H García, A Talavera, L García. (CUBA).

46. PERSISTENCE OF TETANUS AND DIPHTHERIA ANTITOXIN IN CUBAN PRESCHOOL CHILDREN.Martínez JC, Ochoa RF, Ferriol XR, Estrada EA, Sotolongo FT. (CUBA).jcmartinez@finlay.edu.cu

47. TETANUS AND DIPHTHERIA ANTITOXIN LEVELS IN NEWBORNS FROM HAVANA CITY.Martínez JC, Ochoa RF, Ferriol XR, Estrada EA, Sotolongo FT. (CUBA).jcmartinez@finlay.edu.cu

48. A PRELIMINARY EVALUATION OF THE PROTECTIVE CAPACITY OF A PREPARATION OFIMMUNOGLOBULINS ANTI LYPOPOLISACCHARIDES OF Pseudomonas aeruginosa SEROTYPEO11. J Almenares, S Sifontes, J Cobián, A Moya, A Cádiz, D Díaz, M Camacho. (CUBA).almenare@yahoo.es and juan@cebi.uo.edu.cu

49. EXPERIENCE ON THE DEVELOPMENT OF BIOMODELS FOR HAEMOPHILUS INFLUENZAE TYPEB INFECTION. JF Infante, S Sifontes. (CUBA). jinfante@finlay.edu.cu

50. BEHAVIOUR OF THE INMUNOLOGICAL PARAMETERS IN PATIENTS WITH PIODERMITIS. L.Sánchez, I. Martén, E. Lay, X. Rodriguez . (CUBA). Isabel@hospclin.scu.sld.cu

5 51. EVALUATION OF THE IMMUNE HUMORAL RESPONSE AGAINST B AND C SEROGROUPS OFNEISSERIA MENINGITIDIS IN INFANTS VACCINATED WITH VA-MENGOC-BC. L A. PeláezYañez, E. Estrada, R. Ochoa. (CUBA). ochoa@finlay.edu.cu

52. MOUSE MONOCLONAL ANTIBODIES AGAINST OUTER MEMBRANE PROTEINS OF THE CUBANVACCINE STRAIN OF NEISSERIA MENINGITIDIS B:4:P1.19.15. M. E. Pérez, Barbera R., OteroO, Gutiérrez M., Domínguez F, Vidal T, Sierra G, Campa. C. (CUBA). meperez@finlay.edu.cu

53. STUDY OF THE PROTECTIVE CAPABILITY IN MICE OF THE STRAIN SALMONELLA TYPHI TY21ª EXPRESSING THE B SUBUNIT OF CHOLERA TOXIN (CTB). ME Sarmiento, I Feria, LRiverón, A Acosta, M Fariñas, JF Infante, G Sierra. (CUBA). aracosta@finlay.edu.cu

54. STUDY OF THE EXPRESSION OF THE B SUBUNIT OF CHOLERA TOXIN IN DIFFERENT LIVEATTENUATED VECTORS. ME Sarmiento, A Acosta , J Díaz , M Martínez, P Estévez , G Sierra.(CUBA). aracosta@finlay.edu.cu

55. EXPERIMENTAL MURINE CRYPTOCOCCOSIS. Odalis Asín Milán, Gerardo Martínez Machín,Maria Teresa Ilnaitt, Ileana Valdez. (CUBA). oasin@ipk.sld.cu

56. CHARACTERIZATION OF SHIGELLA FLEXNERI STRAINS: SEROTYPE CORRELATION,ANTIMICROBIAL SUSCEPTIBILITY AND PLASMÍD PROFILE. Roberto Cabrera , MargaritaRamírez , Laura Bravo, Anabel Fernández, Nelsideismy Castañeda. (CUBA). roberto@ipk.sld.cu

57. CARACTERIZATION OF THE IMMUNE RESPONSE OF A VACCINE PREPARATION AGAINSTTHE Haemophilus influenzae TYPE B IN RABBIT SERA. V Vérez, V Fernández, A Rodríguez-Silva, F Cardoso, M Izquierdo, A Mussachio, Y Valdés, MC Rodríguez, L Heynngnezz, J Chang,E Hardy (CUBA). arlene.rodriguez@cigb.edu.cu

58. PRODUCTION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES AGAINST THETOXIN CO-REGULATED PILUS OF VIBRIO CHOLERAE. G. Falero, BL. Rodriguez, I. Rodríguez, J.Campos, T. Ledon, E. Valle, Y. Silva, K. Marrero, T. Valmaseda, A. Moreno, R. Fando (CUBA).boris@biocnic.cneuro.edu.cu

59. GENERAL CHARACTERISTICS OF RECOMBINANT MOREAU BCG STRAIN CARRYING 5CPROTEIN Neisseria meningitidis GENE. I. Griñán; T. Vidal; V. Pasos; C. Campa; G. Sierra, A.Acosta; ME. Sarmiento; JF. Infante. (CUBA)

60. RECENT ADVANCES IN THE STUDY OF DCTXPHI, HAP::CELA LIVE CHOLERA VACCINECANDIDATES IN VOLUNTEERS. Rafael Fando, Luis García, Arturo Talavera, Hilda García,Bárbara Cedré, Javier Campos, Boris L. Rodríguez, José L. Pérez, Tania Valmaseda, OliverPérez, Alberto Pérez, Margarita Ramírez, Laura Bravo, Irma González, Talena Ledón, ManuelDíaz Jidy, Miriam Lastre. (CUBA) fando@biocnic.cneuro.edu.cu

6 61. CONTRIBUTION TO THE STUDY OF THE INFANT CRIPTOCOCOSIS IN CUBA. Rosaura F.Escobar Aragón. (CUBA). rossy@infomed.sld.cu

62. EXPRESSION OF TCP AND MSHA MAJOR PROTEINS FROM VIBRIO CHOLERAE STRAINS,CULTURE IN DIFFERENT CONDITIONS BY USING SPECIFIC MONOCLONAL ANTIBODIES. Y.Silva, BL. Rodríguez, J. Campos, T. Ledon, K. Marrero, E. Suzarte, E. Martinez, A. Moreno, G.Falero, I. Rodríguez, R. Fando (CUBA). yussuan@biocnic.cneuro.edu.cu

63. EVALUATION OF MUCOSAL IMMUNOGENICITY OF 638 ORAL LIVE ATTENUATED EL TORCANDIDATE VACCINE STRAIN. J del Campo et al. (Cuba) judithc@finlay.edu.cu

64. SEARCHING TARGETS FOR ADJUVANT SCREENING. D. Gil et al. (CUBA)inmunobyc@finlay.edu.cu

65. PREVALENCE OF HELICOBACTER PYLORI INFECTION AND CHARACTERISTICS OF STRAINSIN LA HABANA, CUBA. B. Gutiérrez, C. Camou-Juncas, A. Santos, T. Vidal, C. Valmaña, N.González, I. Leonard, R. Martínez, O. Díaz-Canel, M. Paniagua, M.P. Escobar, G. Sierra, G.L.Mendez, Francis Mégraud (CUBA-FRANCE-AUSTRALIA / CUBA-FRANCIA-AUSTRALIA)

IMMUNOLOGY OF BACTERIAL DISEASES II

1. IMMUNOGENICITY OF SALMONELLA TYPHI VI POLYSACCHARIDE VACCINE IN CUBANSCHOOL CHILDREN. Ochoa Azze RF, Martínez Rodríguez JC, Baró Suárez IM, Ginebra IniestaM, Ferriol Marchena XR, Rodríguez Alfonso VM, Sotolongo Padrón FT, Mirabal Sosa M,Armesto del Río M, Leiva Sánchez TA, Menéndez Hernández J, Domínguez HernándezF.(CUBA). ochoa@finlay.edu.cu

2. COMPARISON OF THE IMMUNOGENICITY OF SYNTHETIC LINEAR AND MULTIPLE ANTIGENPEPTIDES CONTAINING A PROTECTIVE EPITOPE DERIVED FROM THE MENINGOCOCCALPROTEIN PorA (SUBTYPE 15). S Gonzalez, He Garay, A Cabrales, E Caballero, O Reyes, RPajon. (CUBA). sonia.gonzalez@cigb.edu.cu

3 3. T-CELL RESPONSE AGAINST THE P64k MENINGOCOCCAL PROTEIN IN BALB/C MICE. SGonzález, C Nazábal, KVS Rao, O Reyes, HE Garay, Sardiñas G, Caballero E, Silva R. (CUBA-INDIA). sonia.gonzalez@cigb.edu.cu

4 4. SELECTION OF PHAGE-DISPLAYED MIMOTOPE OF NEISSERIA MENINGITIDIS SEROGROUP BCAPSULAR POLYSACCHARIDE. Menéndez T, Cruz Y, Coizeau E, Garay H, Carmenate T,Alvarez A, Guillén G.(CUBA). tamara.menendez@cigb.edu.cu

5 5. HELICOBACTER PYLORI INFECTION IN HAVANA, CUBA . PREVALENCE AND CAGE STATUSOF THE STRAINS. B. Gutiérrez, C. Camou, A. Santos, T. Vidal, C. Valmaña, N. González, I.Leonard, R. Martínez, O. Díaz-Canel, M .Paniagua, M.P. Escobar, G. Sierra. (CUBA).

6 6. IMMUNOGENICITY AND PROTECTION INDUCED BY THE CUBAN TRIVALENT LEPTOSPIRALVACCINE VAX-SPIRALâ IN RISK POPULATIONS. Y. Rodríguez, M. González, A. González, N.Batista, R. Ochoa, X. Ferriol, M. Baró, M. Armesto.(CUBA). yoandrarod@finlay.edu.cu

7 7. GENERATION OF T CELL LINES AND CLONES FROM A NORMAL DONOR SPECIFIC TOMycobacterium tuberculosis ANTIGENS. Z. Mazorra, G. De Libero. (CUBA-ITALY / CUBA-ITALIA). zaima@ict.cim.sld.cu

8. STUDY OF SPECIFIC ANTIBODIES RESPONSE IN FRONT OF THE PROTEIN OF 38 KD OFMYCOBACTERIUM TUBERCULOSIS IN HEALTHY INDIVIDUALS VACCINATED WITH BCG.Alina Puig Levy, Herve Bercovier, Yolanta Fishmann, Avi-Chai-Hovav, Yamilé López Hernández,María Elena Sarmiento1, Teresita Vidal Martínez, Rolando Ochoa, Eric Estrada, Gustavo Sierra,Armando Acosta. (CUBA-ISRAEL). alina_puig@finlay.edu.cu

9. CUTANEOUS LANGERHANS DENDRITIC CELLS AND gd T CELLS IN A MURINE MODEL OFLEPROSY: IN VIVO ANALYSIS. Sandra Bajaña-Miranda, Adriana Flores-Langarica, JuanaCalderon, Monica Heras-Chavarria, Kendy Wek, Jose Angel Vargas, Oscar Rojas-Espinoza,Leopoldo Flores-Romo. (MEXICO). sbajana@yahoo.es

10. RISK FACTORS FOR CARRIAGE OF Neisseria meningitidis IN A PRIMARY SCHOOL INHAVANA. Martínez I, López O, Sotolongo F, Zamora L, Bencomo A, Climent J, Mirabal M.(CUBA). isamartinez@finlay.edu.cu

11. SPECIFIC IgG ANTIBODIES AGAINST LIPOPOLYSACCHARIDE AND ANTI-ENDOTOXICACTIVITY IN ANTIMENINGOCOCCAL HUMAN IMMUNOGLOBULIN. Balboa JA et al. (Cuba).jbalboa@finlay.edu.cu

12. ANTIBODY RESPONSES TO MYCOBACTERIUM TUBERCULOSIS AND BCG IN TUBERCULOSISPATIENTS. O Orraca Castillo, A Acosta Domínguez, ME Sarmiento García San Miguel, Y LópezHernández, DY Díaz Domínguez, M Martínez Benítez, N Olivares Arzuaga, A Puig Levi ARodríguez Rojas(Cuba). odalys@minsap.pri.sld.cu

13. THE ANTI NEISSERIA MENINGITIDES B VACCINE OVERCOME THE THYMUS INDEPENDENCEOF POLYSACCHARIDE C IN TODDLER. O Pérez, M Lastre, G Bracho, J del Campo, TRodríguez, C Zayas, C Taboada, G Sierra. (CUBA). oliverp@finlay.edu.cu

14. DETECTION OF COMPLEMENT-MEDIATED ANTIBODY-DEPENDENT BACTERICIDAL ACTIVITYIN GROUPS B AND C NEISSERIA MENINGITIDIS COLORIMETRIC SERUM BACTERICIDALASSAY AND ITS VALIDATION. T Rodríguez, M Lastre, B Cedré, J del Campo, E M Fajardo, MHernández, I Delgado, C Zayas, G Sierra, and O Pérez. (CUBA). trodriguez@finlay.edu.cu

15. ANTIBODIES AGAINTS TYPE I HUMAN IMMUNODEFICIENCE VIRUS (VIH) IN PATIENTS WITHTUBERCULOSIS. Zurita Salinas C, Mestanza Peralta M, Coloma NA, Correa M, Cárdenas P.(ECUADOR) jzurita@hcjb.org.ec

16. PHYSICAL-CHEMICAL CHARACTERIZATION BY SDS SOLUBILIZA-TION OF THE OUTERMEMBRANE FROM LEPTOSPIRA POMONA SEROVAR MOZDOK. M Machado Herrera; MNaranjo; M Gonzáles; R Medina; E Abreu; J Abreu; N Batista; V Torres; A Gonzáles; J Oramas.(CUBA) mmachado@finlay.edu.cu

IMMUNOLOGY OF VIRAL DISEASES

7 1. IMMUNE CELLULAR AND HUMORAL RESPONSE IN DIABETES PATIENTS VACCINATED WITHCUBAN ANTI-HEPATITIS B VACCINE. Ariel Jesús Jauma Rojo (Cuba).

8 2. AUTOANTIBODIES DETERMINATION IN PATIENTS WITH MALIGNANT HEMOPATHIES ANDHEPATITIS C. AM Guerreiro et al. (Cuba) ihidir@hemato.sld.cu

3. ESTABLISHMENT OF THE ELISA SYSTEM FOR THE DETECTION OF CAPSIDE ANTIGEN FROMHEPATITIS B VIRUS. M. Peña, Y. Lobaina, Z. Nuñez, Y. Pestana, O. Amarantes. (Cuba)maxlenin@cigb.edu.cu

4. ANALYSIS OF B AND T CELL ACTIVATION IN MESENTERIC LYMPH NODES FROM MICEINFECTED WITH ROTAVIRUS. E Esquivel, L X-Gutierrez, S Lopez, C Arias, F Esquivel.(MEXICO). fernando@ibt.unam.mx

2 5. EVALUATION OF IMMUNE RESPONSE OF INFECTED DENGUE PATIENTS TO RECOMBINANTNS1 AND E PROTEINS. G Mellado Sánchez , L Santos Argumedo, L Cedillo Barrón. (MEXICO).gmellado2001@yahoo.com.mx

6. DENGUE VIRUS INFECTION INDUCES AN INCREASE IN THE EXPRESSION OF DEATHRECEPTOR TNF-R AND ADHESION MOLECULE ICAM-1 AND SUGGESTS APOPTOSIS OFMICROVASCULAR ENDOTHELIAL CELLS (HMEC-1). S Fonseca-Coronado, L Santos-Argumedo,L Cedillo-Barrón (MEXICO). sfonseca@encb.ipn.mx

7. GENE EXPRESSION IN HUMAN MACROPHAGES INFECTED WITH DENGUE VIRUS. MMBMoreno-Altamirano, M Romano, M Legorreta-Herrera, FJ Sánchez-García, MJ Colston.(MEXICO). bertha@lambda.gene.cinvestav.mx

8. HIV RNA LEVEL IN CUBAN PATIENTS. A González, A Alvarez, S Palma (CUBA).aileen@ipk.sld.cu

9. NEUROIMMUNE EPIDEMIOLOGICAL VALUE OF REIBERGRAM IN THE FIRST ECHOVIRUS 16MENINGOENCEPHALITIS OUTBREAK IN CUBA. AJ Dorta-Contreras, H Reiber, ME Magraner-Tarrau, B Weissbrick, MT Interián-Morales, E Noris-García, X Escobar-Pérez, T GonzálezHernández (CUBA-GERMANY / CUBA-ALEMANIA)

10. VIRAL LOADS AND PHENOTYPIC MARKERS OF HIV PROGRESSION IN CUBAN PATIENTS. AAlvarez, A González, R Molina, C Luzardo, O Calderon. (CUBA). aileen@ipk.sld.cu

11. INFECTIVITY STUDY OF DENGUE VIRUS STRAINS USING IMMUNOFLUORESCENCETECHNIQUE. A Aguilar,N Amin, EM Pérez, G Bolaños, EC Rodríguez, A Talavera. (CUBA)

12. SERUM LEVELS OF IL-12, IL-10, RANTES AND NITRIC OXIDE IN DENGUE VIRUS INFECTEDPATIENTS. AB Pérez, G García, T Denny, B Sierra, MV Cabrera, M Alvarez, J Bacallao, MGGuzmán. (CUBA-USA / CUBA-EEUU). anab@ipk.sld.cu

13. TUMOR NECROSIS FACTOR ALPHA AND NITRIC OXIDE IN BLOOD CELLS SUPERNATANTSSTIMULATED WITH DENGUE VIRUS. AB Perez, G García, B Sierra, M Alvarez, MV Cabrera, LValdés, S Vázquez, MG Guzmán. (CUBA). anab@ipk.sld.cu

14. ADCC AND DENGUE VIRUS INFECTION: CONTROL OR DAMAGE? G García, MC Arango, ABPérez, L Fonte, B Sierra, R Rodríguez, E Aguirre, MG Guzmán. (CUBA). anab@ipk.sld.cu

15. A DNA VACCINE OR RECOMBINANT PROTEINS BUT NOT HCV INOCULUMS INDUCED BOTHCELLULAR AND HUMORAL IMMUNE RESPONSES IN MACACA IRUS. A Vina-Rodriguez, SDuenas-Carrera, R Martínez, JC Alvarez-Obregón, J Marante, B Gras, I Gonzalez-Perez, LAlvarez-LajonchEre, G Martinez Donato, EG. Rodríguez, G Guillen Nieto, K Cosme, J MoralesGrillo. (CUBA). Ariel.Vina@cigb.edu.cu

16. MICE LYMPHOPROLIFERATIVE RESPONSES INDUCED BY A DEN4 TRUNCATEDRECOMBINANT E GLYCOPROTEIN. B Sierra, R Rodríguez, L Lazo, L Hermida, C López, GGarcía, AB Pérez, MG Guzmán. (CUBA). siebet@ipk.sld.cu

17. THE RECOMBINANT DEN 2 ENVELOPE B DOMAIN ELICITS A STRONG SEROTYPE SPECIFICLYMPHOPROLIFERATIVE RESPONSE IN MICE. B Sierra, R Rodríguez, L Lazo, L Hermida, GGuillen, MG Guzmán. (CUBA). siebet@ipk.sld.cu

18. DIALYZABLE LEUKOCYTE EXTRACT (DLE) INHIBITS HIV-1 IN VITRO REPLICATION AS EARLYAS 24 HOURS OF INCUBATION BEFORE VIRUS CHALLENGE IN MT-4 CELLS. Fernández-Ortega C, Ojeda M, Giselle A, Ramos Y, Navea L, Rodríguez L, Casillas D, Lovaina L, Noa E,Ruibal I, M Dubed. (CUBA) celia.fernandez@cigb.edu.cu

19. MODIFIED VACCINIA VIRUS ANKARA (MVA) PRIMING AND FOWLPOX VIRUS BOOSTERELICIT STRONGER CTL RESPONSE IN MICE AGAINST AN HIV-1 EPITOPE THAN DNA-POXVIRUS PRIME-BOOST APPROACH. D Vázquez-Blomquist, D Quintana, CA Duarte.(CUBA).dania.vazquez@cigb.edu.cu

20. IMMUNIZATION WITH MAPs COUPLED TO CARRIERS: INFLUENCE OF THE EPITOPIC DENSITYAND PRE-EXISTING IMMUNITY TO THE CARRIER. E Iglesias, JC Aguilar, S Martínez, HE Garay,O Reyes. (CUBA). enrique.iglesias@cigb.edu.cu

21. OZONE THERAPY IN AIDS. A CASE REPORT. N.I. Méndez, S. Menéndez, J. Rivero. (CUBA).ozono@infomed.sld.cu

22. HLA ASSOCIATION IN CUBAN PATIENTS INFECTED WITH HUMAN IMMUNODEFICIENCYVIRUS TYPE I. STUDY PRELIMINARY. I García, J Suárez, R Alegre, A Alvarez, J Pérez. (CUBA).igprod@infomed.sld.cu

23. IMPROVEMENT OF HCV-SPECIFIC IMMUNE RESPONSES USING A NEW VECTOR OF THEpMAE PLASMID SERIE. J Marante, A Vina-Rodriguez, N Lorenzo, E Brown, EG Rodríguez, SDuenas-Carrera. (CUBA). Ariel.Vina@cigb.edu.cu

24. INDUCTION OF HUMORAL IMMUNE RESPONSE USING HUMAN INTERFERON ALPHA 2B ANDRECOMBINANT ANTI-HEPATITIS B VACCINE IN ASYMPTOMATIC CARRIER PATIENTS OFHEPATITIS B VIRUS. J A Santiesteban Torres, A González Griego, A Alerm González, J AcostaAcosta, V E. González, E García Castillo, A Montenegro, O Ponce de León (CUBA).

4 25. ADJUVANT CAPACITY OF A LIPOPEPTIDE CONTAINING THE LALF31-52 PEPTIDE ON THEIMMUNE RESPONSE SPECIFIC TO THE HCV CAPSIDE INDUCED BY DNA IMMUNIZATION. JCAlvarez-Obregón, A Alvarez, L Alvarez-Lajoncherè, O Reyes, I Guerra, J Morales, S Dueñas-Carrera. (CUBA) jcaobregon@cigb.edu.cu

26. CHARACTERIZATION AND IMMUNOLOGICAL EVALUATION OF TWO VARIANTS OF THEENVELOPE DENGUE 2 PROTEIN. Laura Lazo, Lisset Hermida, Rayner Rodríguez, Aída Zulueta,Carlos López, Ricardo Silva, Glay Chinea, Jorge Martín, Guadalupe Guzmán, Gerardo Guillén.(CUBA). lisset.hermida@CIGB.edu.cu

27. RESPONSE OF NEUTRALIZING ANTIBODIES TO SOUTHEAST ASIAN AND AMERICANGENOTYPE OF DENGUE VIRUS TYPE 2. L Bernardo, A Yndart, S Vázquez, L Morier, MGGuzmán.(CUBA). lidice@ipk.sld.cu

28. IMMUNOLOGICAL EVALUATION OF TWO DIFFERENT CONSTRUCTS OF DENGUE-1-P64kCHIMERIC PROTEINS. Lisset Hermida, Rayner Rodríguez, Laura Lazo, Lídice Bernardo, RicardoSilva, Aída Zulueta, Carlos López, Jorge Martín, Iris Valdés, Delfina del Rosario, Glay Chinea,Guadalupe Guzmán, Gerardo Guillén. (CUBA). lisset.hermida@cigb.edu.cu

29. IMMUNIZATION WITH HCV SYNTHETIC PEPTIDES CONJUGATED TO CARRIER PROTEINSELICITED STRONG ANTIBODY RESPONSE WITHOUT ADJUVANT IN MICE. L Alvarez-Lajonchere, G Martínez, J Morales, S Dueñas-Carrera. (CUBA). santiago.duenas@cigb.edu.cu

30. EVALUATION OF MICE SERA IMMUNIZED WITH SYNTHETIC PEPTIDES OF DENGUE 2 VIRUSUSING ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY ASSAY. MC Montalvo, AB Pérez,G García, S Vázquez, MC Arango, G. Chinea, O Reyes, G Guillén, MG Guzmán. (CUBA).mcary@ipk.sld.cu

31. EVALUATION OF A PANEL WITH ANTIHEPATITIS B POLICLONAL AND MONOCLONALSERUMS FOR SURFACE ANTIGEN EXPRESION DETECTION BY ELISA OF THE HEPATITIS BVIRUS (HBSAG SUBTYPE AYW). M. Peña, Y. Pestana, S. Martinez. (CUBA).maxlenin@cigb.edu.cu

32. PROCUREMENT OF REFERENCE MATERIALS AGAINST RECOMBINANT HBsAG SURFACEANTIGEN. MC Abrahantes, J Reyes, B Reyes, R Sosa, EM González, M Vega, D Arias, RValdés, E Martínez. (CUBA). mc.abrahantes@cigb.edu.cu

33. EVALUATION OF AUTOREACTIVITY AFTER IMMUNIZATION OF BALB/C MICE WITH CUBANRECOMBINANT HEPATITIS B VACCINE. M. Romero, B. Sakic, O. Ponce de León. (CUBA-CANADA) mromero@giron.sld.cu

34. HEPATITIS C VIRAL CORE PROTEIN-EXPRESSING DNA VACCINE INDUCES A STRONG CTLRESPONSE IN MICE. N Acosta-Rivero, S Dueñas-Carrera, L Alvarez-Lajonchere, J Morales.(CUBA). nelson.acosta@cigb.edu.cu

5 35. STUDY OF INFECTION ENHANCEMENT OF DENGUE STRAINS USING A MONOCLONALANTIBODY SPECIFIC TO A RECOMBINANT ENVELOPE PROTEIN FROM DENGUE VIRUS TYPE4. N Amin, M Pupo, R Rodriguez, M Alvarez, H Rodriguez, A Otero, G Guzmán. (CUBA).namin@finlay.edu.cu

36. IMMUNOGENICITY STUDY OF BEAGLE DOGS FROM CELL CULTURE RABIES VACCINES.Odalys Fidalgo Perera, Ernesto Almora Hernández, Arelys Zamora Fuentes, Georgina PardoGómez, Luis Izquierdo, Maylen Argamasilla Martínez, Niurka Rodríguez Pérez y Gustavo SierraGónzalez. (CUBA). ofidalgo@finlay.edu.cu

37. SURFACE MARKERS OF HEPATITIS B VIRUS INFECTION AND RESPONSE TO VACCINATIONIN A COMMUNITY. Serrano O, Leyva A, Alerm A, González A. (CUBA).orlando@labex.scu.sld.cu

38. IgG BUT NOT IgM FROM DENGUE 2 IMMUNE HUMAN SERA REACTS WITH DENGUE 4TRUNCATED E GLYCOPROTEIN EXPRESSED IN PICHIA PASTORIS. Rayner Rodríguez, MayraMuné, Susana Vázquez, Gabriel Márquez, Lisset Hermida, Beatriz Sierra, Gerardo Guillén, MaríaG. Guzmán. (CUBA). rayner_rodriguez@yahoo.com

39. IMMUNOLOGIC EVALUATION OF A DTP-HB VACCINE FORMULATION FOR NASALADMINISTRATION. JC Aguilar, R Alemán, Y Lobaina, JC Álvarez, E Iglesias, D García, V Muzio,E Hardy, E Pentón, D Urquiza, N Expósito, G Guillén. (CUBA). regis.aleman@cigb.edu.cu

40. STUDY OF THE ANTIBODIES RESPONSE AGAINST DENGUE VIRAL PROTEIN IN PATIENTSWITH PRIMARY AND SECONDARY INFECTIONS. Sheila Cabezas, Susana Vázquez, MaritzaPupo, Naifi Calzada , Lissette Pérez and María G. Guzmán (CUBA). sheila@ipk.sld.cu

41. INFLUENZA VACCINE: HUMORAL IMMUNITY FOR THE A/JOHANNESBURG/82/96 IN ANELDERLY HOUSE.S Oropesa, A Fanjul, J Muñoz, B Acosta, A Piñón, B Espinosa, MA Oquendo,O Soublet. (CUBA). s.oro@ipk.sld.cu

42. KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) SEROPREVALENCE IN CUBANPOPULATIONS. V Kourí, SM Eng, ME Rodríguez, S Resik, O Urraca, PS. Moore, Y Chang, LGonzález (CUBA). vkouri@ipk.sld.cu

43. SEROLOGICAL SURVEILLANCE OF MEASLES, RUBELLA AND MUMPS. CUBA 1992-2002. GTorres, R Cancio, M ARibas, I Salazar. (CUBA). gisset@ipk.sld.cu

44. RECOMBINANT HBsAg AGGREGATED "IN VITRO" BY OXIDATIVE STRESS : STUDIES OF ITSANTIGENIC PROPERTIES. Sewer M. , Ramirez W., Tleugabulova D., Fleitas Y., Aguilar J.,Penton E. (CUBA). labrada@biocen.colombus.cu

ADJUVANTS

1. ANALYSIS OF THE CARRIER PROPERTIES OF THE CRY PROTEINS OF Bacillus thuringiensisWHEN ADMINISTERED BY INTRAPERITONEAL AND INTRANASAL ROUTE. G Guerrero, FHernández Terán, L Moreno-Fierros. (MEXICO). gloriaguillermina@correo.unam.mx

2. INTRANASAL ADMINISTRATION OF PEPTIDE T1SP10MN(A) CO-ADMINISTERED WITHCHOLERA TOXIN OR CRY1AC, INDUCE CHANGES IN POPULATIONS MUCOSALLYMPHOCYTES B AND T IN BALB/C MICES. R. Esquivel-Pérez, L. Verdín-Terán, L. Moreno-Fierros (MEXICO). mariespe86@hotmail.com.mx

3 3. INDUCED IMMUNE RESPONSE FOR THE SIMULTANEOUS ADMINISTRATION OF A DNAVACCINE FOR Brucella abortus AND AN ADJUVANT PLASMID (pGM-CSF). A González, RRivers, E Andrews, A Oñate. (CHILE). andregon@udec.cl

4 4. IgA ANTIBODIES AND SISTEMIC T-CELL TOLERANCE BY ORAL IMMUNIZATION WITH ANEntamoeba histolytica PROTEIN FUSED TO CHOLERA TOXIN SUBUNIT B. A Contreras-Rojas, AOlivos, P Ostoa, C Castellanos, JP Laclette, JC Carrero. (MEXICO). carrero@servidor.unam.mx

5 5. EVIDENCES OF SPECIFIC IMMUNO STIMULATING EFFECT AND LOW TOXICITY OF ANNATURAL ADJUVANT CANDIDATE. Batista A, D Fernández, Urdaneta I, Betancourt J, Pérez O.(CUBA).

6 6. EFFECT OF ACEMANNAN AND CALCIUM SALTS ON THE IMMUNE RESPONSE AGAINSTDIFFERENT ANTIGENS. A Pérez, JC Aguilar, AM Herrera, D Urquiza, V Muzio, E Pentón, MJLeal, GE Guillén.(CUBA). anna.perez@cigb.edu.cu

7 7. INFLUENCE OF DIFFERENT ADJUVANTS IN THE IMMUNOLOGICAL RESPONSE AGAINSTDENGUE 2 VIRUS WITH A FUSION PROTEIN. C López, R Rodriguez, L Hermida, L Bernardo, JMartin, I Guerra, L Lazo, A Zulueta, G Guillen, G Guzman. (CUBA). carlos.lopez@cigb.edu.cu

8 8. THE EGF ENCAPSULATION INTO LIPOSOMES MODIFIES ITS IMMUNE RESPONSE IN MICE. MCLuzardo, Y Martínez, L Calderón, Y De León, A De la Barrera, F Pazos, C Alvarez, ME Alonso,ME Lanio (CUBA). mcluzardo@fbio.uh.cu

9. PREPARATION AND EVALUATION OF VI POLYSACCHARIDE-PROTEIN CONJUGATESCOMPOSED OF TETANUS TOXOID OR OMP FROM N. MENINGITIDIS SEROGROUP B AS ACARRIER. M Cuello, O Cabrera, CR Soto, O Pérez, J del Campo, CM Taboada, M Fariñas, GSierra. (CUBA). mcuello@finlay.edu.cu

10. DEVELOPMENT OF AN ADJUVATED VACCINE WITH RAPID DELIVERY AGAINST FOOT ANDMOUTH DISEASE VIRUS (FMDV). V. Quattrocchi, N. Fondevila, S. Pappalardo, A. Sadir, P.Zamorano (ARGENTINA). pzamorano@cicv.inta.gov.ar

11. CHARACTERIZATION OF P64k AS A CARRIER PROTEIN. S González, R Silva, A Alvarez, GGuillén, E Caballero, A Pérez, Z Cinza A Ruíz, F Dickinson, C Nazábal, G Sardiñas, T Serrano, JSosa, D Guzmán, O Gutiérrez. (CUBA). sonia.gonzalez@cigb.edu.cu

212. CUBAN ANTI-HEPATITIS B IMMUNOGLOBULIN AS BIOLOGICAL ADJUVANT. V. E. González et

al. (Cuba). victoria.gonzalez@infomed.sld.cu

3 13. P64K AS A CARRIER PROTEIN OF NEISSERIA MENINGITIDIS PORIN A PEPTIDES. G. Sardiñas,S. Gonzalez, HE Garay, C. Nazábal, O. Reyes, R. Silva. (Cuba). gretel.sardinas@cigb.edu.cu

IMMUNODIAGNOSTICS

1. OPTIMIZATION OF RECOMBINANT STREPTOLYSIN-O EXPRESSION AND ANALYSIS OF FINALPRODUCT FORMULATIONS SUITABLE FOR IMMUNODIAGNOSIS. B Velázquez, H Massaldi andA Chabalgoity. (URUGUAY). bvela@higiene.edu.uy

2. AUTOANTIBODIES AGAINST EXTRACTABLE NUCLEAR ANTIGENS. A URUGUAYANEXPERIENCE. MI Bethencourt, I Iacobovici. (URUGUAY-SPAIN/URUGUAY-ESPAÑA).dosi@adinet.com.uy

8 3. OBTENTION OF HIGH TITRE POLYCLONAL ANTISERA AGAINST PEPTIDIC HAPTENS:MICROCYSTIN LR AND MELITTIN. S Lev. (URUGUAY). sandlev@higiene.edu.uy

4. HUMAN TRYPSINOGEN PURIFICATION FROM PANCREATIC TISSUE FOR CYSTIC FIBROSISIMMUNODIAGNOSIS. Antonio Melchor Rodríguez, Liliana Hernández Pérez, Orlando ZuluetaRodríguez, Carlos Martínez Ortiz, Raquel López Cisneros, Carmen Acosta Bas, Nimia FanegoSerrat, Amarilys Frómeta Suárez. (CUBA). iqpurifica@cie.sld.cu

5. BETA-SUBUNIT HCG PURIFICATION FROM HUMAN CHORIONIC GONADOTROPIN FORIMMUNODIAGNOSIS. Antonio Melchor, Orlando Zulueta, Juliette Cazanave, Liliana Hernández,Carlos Martínez, Ileana Baluja, Dunia Bequec, Celina Machado, Raquel López, Luisa Martínez,Milenen Hernández. (CUBA). iqpurifica@cie.sld.cu

2 6. MONOCLONAL ANTIBODY AGAINST FREE BETA-SUBUNIT OF HUMAN CHORIONICGONADOTROPIN. Ileana B. Baluja Conde, Adys I. Brito Moreno, Carmen Acosta Bas, OrlandoZulueta Rodríguez, Antonio Melchor Rodríguez, Isis Amores Sanchéz, Luisa Martínez, MilenenHernández. (CUBA). iqmonoclo1@cie.sld.cu

7. TRANSGENIC ANTI COAGULATION FACTOR IX. M. Mahia, A. Dìaz, L. Perez, L.E. Ramos, A.Moya, A. Càdiz, M. Limonta. (CUBA). arquidia@infomed.sld.cu

8. IMMUNOLOGICAL CLASSIFICATION OF LYMPHO- AND MYELOPROLIFERATIVE SYNDROMESUSING THE ALKALINE PHOSPHATASE ANTI-ALKALINE PHOSPHATASE (APAAP) METHOD. BBSocarrás, V Marsán, M Sánchez, M Martínez, I Torres, LO del Valle, C Macías, RA Rivero.(CUBA). ihidir@hemato.sld.cu

9. MONOCLONAL ANTIBODY AGAINST HUMAN TRYPSIN: PRODUCTION, CHARACTERIZATION,AND USE FOR DIAGNOSIS. Carmen Acosta Bas, Ileana B. Baluja Conde, Adys I. Brito Moreno,Maya Rosa Rodríguez López, Antonio Melchor, Liliana Hernández, Amarilys Frómeta, María E.Selles, Luisa Martínez. (CUBA). iqmonoclo@cie.sld.cu

10. ENDOTHELIAL ADHESION MOLECULES ICAM-1, VCAM-1 AND E-SELECTIN IN PATIENTSWITH ACUTE CORONARY SYNDROME. Consuelo Macías , Rinaldo Villaescusa , Lázaro delValle , Victor Boffil, Girelda Cordero, Alberto Hernández, Porfirio Hernández , José ManuelBallester. (CUBA). ihidir@hemato.sld.cu

11. EVALUATION OF THE NEUTROPHILS RESPONSE USING THE REDUCTION OF THE NITRO BLUEOF TETRAZOLIUM(NBT) AND THE OPSONOPHAGOCYTIC INDEX TECHNIQUES. Edisley ZailaLago, Yudania Reyes Cepero, Cándido León Márquez, Ernesto Caraballosa Yero. (CUBA).CubaZaila@escambray.ssp.sld.cu

12. ENZYME-LINKED IMMUNOSORBENT ASSAY FOR 17a-HYDROXYPROGESTERONE (17OHP) INSERUM AND DRIED BLOOD SPOTS ON FILTER PAPER. E González, N Marrero, A Frómeta, MMónaga, D Herrera, E Castells, P Pérez, A Baloy, J Hernández. (CUBA). iqtsh@cie.sld.cu

13. VALIDATION OF A NESTED PCR ASSAY UMELOSA HCV FOR DETECTION OF HEPATITIS CVIRUS. I. Gonzalez-Perez, Y. J. González, A. Armas, A. Vina-Rodriguez, A. Medina, N. Trujillo,M.T. Pérez, R.L. Solís. (CUBA). idania_gonzalez@yahoo.es

14. EXPERIENCE OF THE IMMUNOASSAY CENTER IN THE PRODUCTION OF POLYCLONALANTIBODIES FOR IMMUNODIAGNOSIS. L. Martínez; J.R. Vivar; V. Soto; A. Lorenzo; M.Montes de Oca; A. Melchor; O. Zulueta; P. Pérez; I. Valdivia; R. Cápiro; M.L. Hernández; R. DelSol. (CUBA). iqvivario@cie.sld.cu

15. LATEX TEST FOR SERUM MYOGLOBIN IN THE DIAGNOSIS OF ACUTE MYOCARDIALINFARCTION. MC Pico, IG Giraldino, M Alvarez, P Pedroso, H Carol. (CUBA).mcpico@fbio.uh.cu

3 16. CHIMERIC SYNTHETIC PEPTIDES CONTAINING TWO IMMUNODOMINANT EPITOPES FROMTHE GAG P19 PROTEIN AND THE ENVELOPE GP46 GLYCOPROTEIN FOR THEIMMUNODIAGNOSIS OF HTLV-II VIRUS INFECTION. M Hernández, Y Márquez, L Pozo, C Silva,Ch Rodríguez, D Higginson. (CUBA). iqpeptidos@cie.sld.cu

17. ANTIGENIC MIXTURE OF SYNTHETIC PEPTIDES FOR THE IMMUNODIAGNOSTIC OF HTLV-I/II.Y. Márquez, M. Hernández, R.A. Vázquez, L. Pozo, C Silva. (CUBA). iqvih@cie.sld.cu

18. CELLULAR IMMUNOPHENOTYPING IN THE DIAGNOSIS OF CHRONIC LYMPHOID LEUKEMIAS.M Sánchez, V Marsán, B Socarrás, RA Rivero, M Martínez, P Hernández, C Macías, LO delValle. (CUBA). m.sanchez@hemato.sld.cu

19. DETECTION OF HLA-DR15 AND HLA-DQ6 BY PCR-SSP TECHNIQUE AND ITS USE IN THEDIAGNOSIS OF NARCOLEPSY. Raul Ferreira, Flora Calzadilla, Adriana Artiles, Lizette Bonet,Pedro Figueredo. (CUBA).

20. THE USEFULNESS OF UMELOSA HCV CUALITATIVO KIT AS SUPPLEMENTAL TEST FORCONFIRMATION OF HCV INFECTION. I. Gonzalez-Perez, Y. J. González, A. Vina-Rodriguez, A.Armas, R.L. Solís. (CUBA) idania_gonzalez@yahoo.es

21. VALIDATION OF AN ELISA FOR THE QUANTITATION OF MONOCLONAL ANTIBODIESAGAINST THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEIN 24. N Ruiz , MIzquierdo, E Silva, D Martín, MT Pérez. (CUBA). cicdc@infomed.sld.cu

3722. CUBAN ANTI-HEPATITIS B IMMUNOGLOBULIN WITH DIAGNOSTIC AIMS IN VIVO. E. García et

al. (CUBA) elsagc@infomed.sld.cu

23. IMMUNODIAGNOSTIC TEST FOR ANTIBODIES RESPONSE DETECTION AGAINST TICKINFECTION IN BOVINE SERUM SAMPLES. E Torres, C Talavera, R Blanco, N Abad, H Machado,G Gómez. (CUBA) edel@escambray.ssp.sld.cu

IMMUNOTECHNOLOGY

4 1. DENDRITIC CELL IMMUNIZATION IMPROVES PRODUCTION OF MONOCLONAL ANTIBODIESAGAINST THE REGULATOR OF MHC CLASS II EXPRESSION (CIITA). P Vargas, C Cortés, LVargas, M Rosemblatt, MR Bono. (CHILE). pabcovar@icaro.dic.uchile.cl

2. OBTAINING VIRAL IMMUNOGENS BY MEANS OF THE FILAMENTOUS PHAGE DISPLAY.PRELIMINARY RESULTS. Ela María Pérez, Frank Camacho, Osmany Larralde, Félix Daphnis,Odalys Fidalgo, Raiza Martínez, Alicia Aguilar, Nevis Amin, Miriela Capo, Gustavo Sierra.(CUBA). Elaperez@finlay.edu.cu

3. A SENSITIVE COMPETITION ELISA WITH IMMOBILIZED ANTIGEN FOR QUANTIFINGSTICHOLYSINS I AND II, TWO CYTOLYSINS FROM THE SEA ANEMONE Stichodactylahelianthus. A Otero, A Hidalgo, MC Pico. (CUBA). aoterog@infomed.sld.cu PDF

4. PEROXIDASE-LABELED STICHOLYSINS METHOD FOR LOCALIZATION OF STICHOLYSINS INTHE SEA ANEMONE STICHODACTYLA HELIANTHUS. MC Pico, Y Noa, V Pérez, M Izquierdo, OGuerra, JF Infante, A Otero. (CUBA). mcpico@fbio.uh.cu

5. NEUTRALIZATION OF HEMOLYTIC ACTIVITY OF STICHOLYSIN II, A CYTOLYSIN FROM THESEA ANEMONE Stichodactyla helianthus. MC Pico, A Basulto, I Casadelvalle, A.J. Otero.(CUBA). mcpico@fbio.uh.cu

6. POLYCLONAL ANTIBODIES TO SHPI-1, A POLYVALENT PROTEASE INHIBITOR FROM THESEA ANEMONE STICHODACTYLA HELIANTHUS. I Casadelvalle, MC Pico, V Marañón, EFacenda, C Gilvá. (CUBA). isis@fbio.uh.cu

7. VALIDATION OF COLORIMETRIC VIBRIOCIDAL ASSAY FOR DETERMINE SERUM ANTIBODIESTO Vibrio cholerae. Bárbara Cedré, Yutssandry Viel, Tamara Rodríguez, Gemma Año, IrmaGonzález, Ileana Delgado, Hilda García, Yadira Pino, Tania Valmaseda, Arturo Talavera, LuisGarcía. (CUBA). bcedre@finlay.edu.cu

8. VALIDATION OF ELISA FOR DETERMINE ANTIBODIES ANTI-LPS IN HUMAN SERUMINOCULATED BY ORAL ROUTE WITH 638 V. CHOLERAE STRAIN EL TOR OGAWA. YadiraPino Navarro, Tania Valmaseda Pérez, Yudisey Medina Sánchez, Bárbara Cedré Marrero,Gemma Año López, Hilda M. García Sánchez, José Luis Pérez Quiñoy, Arturo Talavera Coronel,Irma González Novo, Ileana Delgado Arrieta y Luis García Imia (CUBA). ypino@finlay.edu.cu

9. IMMUNOPURIFICATION OF THE HEPATITIS B SURFACE ANTIGEN USING A PLANT-DERIVEDHBsAg-SPECIFIC ANTIBODY. Rodolfo Valdés, Biunayki Reyes, Tatiana Alvarez, Janet García,Waldo Ortiz, José A. Montero, Raudel Sosa, Leonardo Gómez, Sigifredo Padilla, YurisleydisAldama , Alejandro Figueroa, Lamay Dorta, Damián Fernández, Deborah Geada and José Brito(CUBA). rodolfo.valdes@cigb.edu.cu

10. INFLUENCE OF THE EXTRACTION BUFFER ON MONOCLONAL ANTIBODY QUANTITY ANDINTEGRITY FROM TOBACCO PLANTS. Rodolfo Valdés, William Ferro,Sigifredo Padilla,Leonardo Gómez, Raudel Sosa, Roberto Pérez, Otto Mendoza,Merardo Pujol, Jose Enrique Brito.(CUBA). rodolfo.valdes@cigb.edu.cu

5 11. OBTENTION OF CHICKEN ANTIBODIES THAT RECOGNIZE NUCLEOSIDE ANALOGS USED INNON RADIOACTIVE DNA DETECTION. Dannelys Perez Bello, Judith Miranda, Mirta ZayasAcosta, Chryslaine Rodriguez Tanty, David Higginson Clarke, Ana María Riverón Rojas, EstebanGutiérrez Calzado, Rüdiger Schade. (CUBA-GERMANY / CUBA-ALEMANIA).

12. MOUSE MONOCLONAL ANTIBODIES AGAINST ABO BLOOD GROUP ANTIGENS IN CUBA: ITSEVALUATION IN THE 4TH INTERNATIONAL WORKSHOP. Rivero RA, Bencomo AA, Alfonso Y,Suárez LE, Díaz M. (CUBA). rrivero@hemato.sld.cu.

13. HUMAN HAEMOCLASSIFICATION BY USE OF SPECIFIC YOLK ANTIBODIES OBTAINED AFTERIMMUNISATION OF CHICKENS AGAINST HUMAN BLOOD GROUP ANTIGENS. RM García, EJGutiérrez, E Schade. (CUBA-GERMANY / CUBA-ALEMANIA). mireyita@cnt.uo.edu.cu

14. COMPARISON OF THREE METHODS FOR NONRADIOACTIVE IN VIVO DNA LABELING INEscherichia coli Dannelys Pérez Bello, Viana Manrique Suárez, Celso Pérez Bolaños, JudithMiranda López, Gabriel Pérez Pérez, Lilia López Canovas, David Higginson Clark, ChryslaineRodríguez Tanty, Ana Maria Riverón Rojas. (CUBA).

15. RIBULOSE 1,5 DIPHOSPHATE; GENERATION OF MONOCLONAL ANTIBODIES FORIMMUNOAFFINITY CHROMATOGRAPHY AND PROTEIN QUANTIFICATION. Déborah Geada,Rodolfo Valdés, Marcos González, Dioslaida Urquiza, Leonardo Gómez, Abdel Hidalgo, DulceMaría Ares. (CUBA). Rodolfo.valdes@cigb.edu.cu

16. CLONING, EXPRESSION AND PURIFICATION OF HUMAN CD6 EXTRACELLULAR DOMAIN INE. COLI USED TO DETECTION HIORT1 MAB. E Santana, A Aguirre, L Ayra, G Márquez, JSánchez, Y Carpio, FO Castro. (CUBA). elaine.santana@cigb.edu.cu

17. PRODUCTION OF MONOCLONAL ANTIBODIES BY THE ASCITES METHOD: ACOMPREHENSIVE ANALYSIS OF THE SCALE TO REDUCE ANIMAL SUFERING. O. Mendoza, R.Valdés, R. Alemán, M. González, B. Reyes, S. Padilla,T. Alvarez, A. Tamayo, D. Fuentes, R.González, O. Hernández, J. Arronte. (CUBA). maria.rosario@cigb.edu.cu

18. IDENTITY TEST OF THE OMV PROTEIN FROM CUBA VACCINE VA-MENGOC-BC® USINGMONOCLONAL ANTIBODIES. M. E. Pérez, Barbera R., Otero O., Domínguez F., Sotolongo F.Sierra G, Campa C. (CUBA). meperez@finlay.edu.cu

19. IMMUNOBLOT VERSUS ELISA FOR THE PRIMARY SCREENING IN THE DEVELOPMENT OFMOUSE MONOCLONAL ANTIBODIES AGAINST OUTER MEMBRANE PROTEINS OF Neisseriameningitidis B:4:P1.(7B).4. M. E. Pérez, Otero O., Barbera R., Gutiérrez M., Domínguez F.,Sotolongo F. Sierra G, Campa C. (CUBA). meperez@finlay.edu.cu

20. GENE THERAPY USING NAKED PLASMID DNA ENCODING VEGF121 IN ANIMAL MODELS OFISCHEMIC DISEASES. AG Ojalvo, A Seralena, NS Vispo, R Silva, R Vázquez, Y Puchades, A Alí,P Lopez-Saura, JF Montequín, LT Sorell, A Aldama, MA Alfonso, Rafael Simón, Armando Seuc,N González, L Guevara, N Chaos, O Creach, R González, JF Batista, Y Peña, M Coca, A Perera,T García-Osuna, H Domínguez, JL Reyes, L Herrera. (CUBA). ariana.garcia@cigb.edu.cu

21. KINETIC OF EXPRESSION OF THE PLANTIBODY-HB01 SPECIFIC FOR THE SURFACE ANTIGENOF HEPATITIS B VIRUS IN Nicotiana tabacum (CUBA) Leonardo Gómez Bayolo, Merardo Pujol,Rodolfo Valdés, William Ferro, Roberto Pérez, Sigifredo Padilla, José Brito, Carlos Borroto,Alberto Núñez, Milagro Font, René Gallo, Julio César Sánchez. (CUBA).Leonardo.gomez@cigb.edu.cu

22. PROCCESSING OF FRESH TRANSGENIC TOBACCO PLANTS FOR PURIFICATION OF A HBsAg-SPECIFIC ANTIBODY. Rodolfo Valdés, Leonardo Gómez, Sigifredo Padilla, Merardo Pujol,Vladimir Leal, Orlando Herrera, Tatiana Alvarez, Otto Mendoza, Jorge Luis Vega, José Brito,Carlos Borroto. (CUBA). Rodolfo.Valdes@cigb.edu.cu

23. DIRECT IDENTIFICATION OF TUMOR ANTIGENS BY AUTOLOGOUS ANTIBODY SCREENING. OGires, M Muenz, M Schaffrik, C Kieu, B Mack, W Hammerschmidt, R Zeidler. (GERMANY).ogires@hno.med.uni-muenchen.de

TUMOR IMMUNOLOGY AND IMMUNOTHERAPY

1. ADVANCES IN THE DETERMINATION OF TUMOR MARKERS IN COLORECTAL CARCINOMA. MV Croce, AG Colussi, G Ramacciotti, A Segal-Eiras (ARGENTINA). as-eiras@netverk.com.ar

2 2. PATTERNS OF MUC1 TISSUE EXPRESSION DEFINED BY AN ANTI MUC1 CYTOPLASMIC TAILMONOCLONAL ANTIBODY IN BREAST CANCER. MV Croce, M Isla-Larrain, C Rua, M Rabassa,A Segal-Eiras. (ARGENTINA). mrabassa@atlas.med.unlp.edu.ar

3 3. EXPRESSION OF CARBOHYDRATE AND PEPTIDIC ANTIGENS IN BREAST CANCER. MV Croce,M Isla-Larrain, C Rua, A Segal-Eiras. (ARGENTINA). as-eiras@netverk.com.ar

4. INTRATUMORAL AND REGIONAL LYMPH NODES CYTOKINES GENE EXPRESSION IN BREASTCANCER PATIENTS. L Llanes-Fernández, MC Arango-Prado, JM Alcocer-González, V Madrid-Marina, S Franco-Odio, R Camacho-Rodríguez, AM González-Sánchez, R Tamez-Guerra, CRodríguez-Padilla. (CUBA-MEXICO)

5 5. WALKER 256 TUMOR MHC CLASS I EXPRESSION DURING THE SHIFT FROM "A" VARIANTINTO THE IMMUNOGENIC "AR" VARIANT. AS Schanoski, PB Juliano, CBL Campos, TCSCavalcanti, AN Viera-Matos, O Rettori, F Guimarães. (BRASIL/BRAZIL). aless007@yahoo.com

6 6. THE ANTI-TUMORAL ACTIVITY OF VEGETAL SPECIES FOUND IN AMAZONIC REGION. FRFNascimento, BTF Silva, JO Viana, GB Cruz, K Arruda, N Gadelha, RNM Guerra.(BRASIL/BRAZIL). nascimentofrf@yahoo.com.br

7 7. POSSIBLE PARTICIPATION OF THE COMPLEMENT SYSTEM IN THE DEVELOPMENT OFAUTOIMMUNE MANIFESTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA. R Villaescusa, etal. (Cuba). rvillaescusa@hemato.sld.cu

8 8. TREATMENT OF LEUKEMIC CELLS (HL60) WITH DIMETHYLAMIDE-CROTONIN TRIGGERSAPOPTOSIS DEPENDENT OF CASPASES -2 AND -9, BUT NOT CASPASE -6 ACTIVATION. MCAnazetti, PS Melo, N Durán, M Haun. (BRAZIL/BRASIL). mcanazetti@bol.com.br

9 9. REGULATION OF Bcl-2 EXPRESSION IN LEUKEMIC CELLS (HL60) BY VIOLACEIN AS AMECHANISM OF APOPTOSIS INDUCTION. N Bromberg, PS Melo, C Bincoletto, GZ Justo, MHaun, N Durán (BRAZIL/BRASIL). natalia@iqm.unicamp.br.

0 10. ANTITUMORAL ACTIVITY OF DEHYDROCROTONIN. PS Melo, GZ Justo, N Durán, M Haun.(BRAZIL/BRASIL). pmelo@unicamp.br

11. POLYAMINES AS BIOMARKERS OF NEOPLASTIC GROWTH IN MICE WITH L5178YLYMPHOMA TREATED WITH Bursera fagaroides. R Reynoso, A Santerre, J I Delgado, CSandoval, A Puebla.(MEXICO). rreynoso@cucba.udg.mx

12. RED BLOOD CELLS OSMOTIC FRAGILITY ALTERATIONS INDUCED BY TOTAL AND PLASMAFRACTIONS FROM RATS BEARING PROGRESSIVE AND REGRESSIVE VARIANTS OF WALKER256 TUMOR. TC Cavalcanti, CC Gregorini, F Guimarães, O Rettori, AN Vieira-Matos(BRAZIL/BRASIL). samico@caism.unicamp.br

13. EFFECTOR, MEMORY AND NAIVE PHENOTYPES IN CYTOTOXIC T LYMPHOCYTES FROMLUNG ADENOCARCINOMA PATIENTS. H Prado-García, D Aguilar Cázares, H Flores-Vergara, HMorales-Fuentes, F Ávila-Moreno, JS López-González. (MEXICO). hpradog@yahoo.com.

14. PULMONARY CARCINOMAS INDUCE ALTERATIONS IN DIFFERENTIATION, MATURATIONAND FUNCTION OF HUMAN DENDRITIC CELLS. F Ávila-Moreno, S J López-González, H Prado-García, C Sánchez-Torres. (MEXICO). avilamore@hotmail.com

15. MODULATION OF THE CELLULAR IMMUNE RESPONSE AND CYTOKINES PRODUCTION BY INVITRO PERILLYL ALCOHOL ON T CELLS FROM TUMOR-BEARING MICE. E Flores, S del Toro, Adel Toro, T García, MG Ramírez, A Daneri. (MEXICO). E-mail: inmeftdr@hotmail.com

16. NKG2D AND 2B4 EXPRESSION ON NK CELLS FROM PATIENTS WITH CERVICALCARCINOMA. S del Toro, A del Toro, T García, J Peregrina, E Flores, MG Ramírez, A Daneri.(MEXICO). susana@cucs.udg.mx

17. EXPRESSION OF ZETA CHAIN IN T LYMPHOCYTES AND NK CELLS FROM PATIENTS WITHUTERINE CERVICAL CARCINOMA. T García, A del Toro, J Peregrina, E Sánchez, P Sánchez, Sdel Toro, A Daneri. (MEXICO). tgarcia@cucs.udg.mx

18. CD44-HYALURONIC ACID INTERACTION MODULATES METALLOPROTEINASES IN A T CELLMURINE LYMPHOMA AND IN INFLAMMATORY LEUKOCYTES. L Alaniz, P Cabrera, SGreczanik, G Blanco, E Alvarez, SE Hajos. (ARGENTINA). laualaniz@yahoo.com

19. IMMUNOTHERAPY OF ADVANCED BREAST CANCER WITH AN HETEROPHILIC GANGLIOSIDE(NEUGCGM3) CANCER VACCINE. A Carr, E Rodríguez, MC Arango, R Camacho, M Osorio, GCarrillo, Z Valdés, Y Bebelagua, M Gabri, R Pérez, LE Fernández. (CUBA-ARGENTINA).adriana@ict.cim.sld.cu

2 20. EPIDERMAL GROWTH FACTOR RECEPTOR-BASED ACTIVE IMMUNOTHERAPY OF CANCER.Anabel de la Barrera. (CUBA). anabel@ict.cim.sld.cu

21. EXPRESSION OF LYMPHOCYTE SURFACE ANTIGENS IN BREAST CANCER PATIENTS. AGonzález, E Noris, A Torrella, M C Arango, T Badía, M E Faxas. (CUBA).alymar@infomed.sld.cu

22. A MONOCLONAL ANTIBODY AGAINST NeuGc-CONTAINING GANGLIOSIDES CONTAINS AREGULATORY IDIOTOPE INVOLVED IN THE INTERACTION WITH B AND T CELLS. A Perez, ESMier, N Santiago Vispo, AM Vazquez, R Perez. (CUBA). rolando@ict.cim.sld.cu

23. A CHIMERIC ANTI-N-GLYCOLYL-GANGLIOSIDE ANTIBODY: IMMUNODOMINANCE OF ITSVARIABLE REGION. A Lopez, C Mateo de Acosta, J Lombardero, K Sosa, R Perez, AMVazquez. (CUBA). maruchi@ict.cim.sld.cu

24. IMMUNE RESPONSES IN BREAST CANCER PATIENTS IMMUNIZED WITH AN ANTI-IDIOTYPICANTIBODY MIMICKING NeuGc-CONTAINING GANGLIOSIDES. A Díaz, M Alfonso, R Alonso, GSaurez, M Troche, M Catalá, RM Díaz, R Pérez, AM Vázquez. (CUBA). maruchi@ict.cim.sld.cu

25. A TGFa CANCER VACCINE. Ayllete Mulet, Greta Garrido, Anabel Alvarez, Tamara Menéndez,Rolando Pérez, Luis Enrique Fernández. (CUBA). luis@ict.cim.sld.cu

26. EVALUATION OF THE HUMORAL IMMUNE RESPONSE TO NEUGCGM3/ VSSP VACCINE INMETASTATIC MELANOMA PATIENTS. A. Torrella, E. Noris, A. González, M.C. Arango, B.Rodríguez, M. Osorio, L. Anasagasti, E. Rodriguez, R. Mon, A. Carr, L.E. Fernández (CUBA).atorella@infomed.sld.cu.

27. INDUCTION OF IMMUNE RECOGNITION TO AUTOLOGOUS EGFR. B Sánchez. A de la Barrera,E Suárez, R Pérez, A Ullrich, LE Fernández.(CUBA). belinda@ict.cim.sld.cu

28. CD6+ CELLS IN BENIGN BREAST LESIONS AND CANCER DEVELOPMENT M E Faxas García, IPérez B, M E Guerra Y. (CUBA). mefaxas@infomed.sld.cu

29. RISK FACTORS AND IMMUNOLOGICAL PARAMETERS IN CERVICAL CANCER. G. León, MEFaxas, B. Rodríguez, O. Bosques Diego, R. Ruiz Lorente. (CUBA). mefaxas@infomed.sld.cu

3 30. CHARACTERIZATION OF IMMUNOGENICITY AGAINST TWO GROWTH FACTORS (EGF ANDTGF ALPHA) USING RECOMBINANT FUSION PROTEINS BETWEEN THESE MOLECULES ANDP64K PROTEIN FROM NEISSERIA MENINGITIDIS AS A NEW CANCER VACCINE APPROACH. GGarrido, A Mulet, A Álvarez, T Menéndez, L.E Fernández. (CUBA). greta@ict.cim.sld.cu

31. LHRH BASED VACCINE DECREASE THE VOLUME OF PROSTATE IN ADULT MALE RATS. FFuentes, L Calzada, J Junco, R Basulto, E Bover, E Pimentel, Y López, H Hernández. (CUBA).franklin.fuentes@cigbcam.cigb.edu.cu

32. PERIPHERAL T CELL REGULATION AGAINST SELF-ANTIGENS IN AUTOIMMUNITY ANDCANCER. E. Montero, G. Nussbaum, J. Kaye, R. Perez, A. Lage, I. Cohen.(CUBA-ISRAEL).enrique@ict.cim.sld.cu

33. LEUKOCYTE AND RECOMBINANT INTERFERON IN THE TREATMENT OF MYCOSIS FUNGOIDE.LONG-TERM SURVIVAL. A del Río, S Collazo, B Sagaró, B Gutiérrez, M Cortina, C Ochoa, CValenzuela, P López-Saura. (CUBA). amaury@cigbdec.cigb.edu.cu

34. T CELL AND GANGLIOSIDES BASED VACCINES: ARE THEY INVOLVED? C. Mesa, Z. Mazorra,L.E.Fernández (CUBA) luis@ict.cim.sld.cu

35. EVALUATION OF THE HUMORAL IMMUNE RESPONSE TO NEUGCGM3/ VSSP VACCINE INADVANCED BREAST CANCER PATIENTS. E. Noris, A. Torrella, A. González, MC. Arango, B.Rodríguez, M. Osorio, L. Anasagasti, E. Rodriguez, R. Mon, A. Carr, L.E. Fernández. (CUBA).anoris@infomed.sld.cu

36. IMMUNOGLOBULIN DISTURBANCES IN PATIENTS WITH HODGKIN´S DISEASE. A Arce, RVillaescusa, JC Merlín, AM Guerreiro, LM Morera, C Ustariz, P Hernández. (Cuba).ihidir@hemato.sld.cu

ANTIGEN PRESENTATION/TRANSPLANTATION

1. THE DECREASE ON T CELL COUNTS AFTER A SINGLE DOSE OF IMMUNOSUPPRESSIVEDRUGS IN RENAL TRANSPLANT PATIENTS CAN BE ASCRIBED TO A LOW DOSE OFPREDNISONE. D Sauma, R Mora, A Fierro, J Morales, C Herzog, M Rosemblatt, MR Bono.(CHILE). dmsauma@mi-mail.cl

2. REPRESENTATION OF CLASS I AND II ANTIGENS IN RECEIVERS OF KIDNEY GRAFTS. M CClares, M. Domínguez. (CUBA). ucilora@hsl.scu.sld.cu

3. HLA EXTENDED HAPLOTYPES IN A SAMPLE OF THE CUBAN CONTEMPORARY POPULATION.R Alegre, I Garcia, J Suárez, J Beltrán, J Martínez-Laso, E Gómez-Casado, A Arnaiz-Villena.(CUBA-SPAIN / CUBA-ESPAÑA). cmcaiba@capiro.vcl.sld.cu

4. GENETIC AND PHENOTYPICAL FREQUENCY STUDY OF HLA ANTIGENS INOPHTHALMOLOGICAL DISEASES: VOGNT - KOYANAGI - HARADA AND PRIMARY OPENANGLE GLAUCOMA. LM Morera et al. (CUBA) ihidir@hemato.sld.cu

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