Integrinactivation

Basement Membrane(e.g. Collagen IV and Laminin)

Transitional Matrix(e.g. Fibronectin and Fibrinogen)

ATHEROGENESIS

Flk1

VE-cadherin

PECAM-1

α2β1

IKK

JNK

Rac

MKK4

?

NF-κB

PECAM-1

Permeability

Pro-inflammatorygene expression

ICAM-1VCAM-1

Flk1

VE-cadherin

α5β1, αvβ3

NADPHoxidase

NADPHoxidase

PI 3-kinase

PI 3-kinase

Rac

Src

PAK

PAKSrc

Discover more at abcam.com/integrin

Integrin Signaling in Shear Stress-inducedEndothelial Cell Dysfunction Pathway

Produced in collaboration with Dr. A. Wayne Orr, LSU Health Sciences Center.

Discover more at abcam.com/integrin

080-09/09-PW

Copyright © 2013 Abcam. All Rights Reserved.

Integrin Signaling in Shear Stress-induced Endothelial Cell Dysfunction PathwayRelated antibodiesAntibody Clonality Applications Host Species Reactivity Product Code

Collagen IV P IHC-P, IHC-FoFr, IP, WB, ELISA, IHC-Fr Rb Hu, Ms, Rat, Cow ab6586

Fibrinogen P IHC-P, ELISA, ICC/IF, FuncS Rb Hu, Ms, Rb ab34269

Fibronectin M AP, ICC/IF, IHC-Fr, IHC-P, RIA, WB Ms Hu, Ms, Rat, Chk, Cow, Dog, Pig ab6328

FLk1 / VEGF Receptor 2 P IP, Flow Cyt, IHC-P, ICC/IF, IHC-Fr Rb Hu, Ms, Rat, Cow, Dog ab2349

ICAM1 M ELISA, Flow Cyt, IP, WB Ms Hu, Rat, Cow ab2213

IKK alpha + IKK beta P IHC-P, ELISA Rb Hu, Ms ab62481

Integrin alpha 2 M IP, Flow Cyt, IHC-P, IHC-Fr Ms Hu ab10800

Integrin alpha 2 + beta 1 M Flow Cyt, IP, WB, ELISA, ICC/IF, IHC-Fr Ms Hu ab30483

Integrin alpha 5 M Flow Cyt, ICC/IF, IP Ms Hu ab6131

Integrin alpha 5 + beta 1 M Flow Cyt, IP, Inhib, WB, IHC-Fr Rat Ms ab77981

Integrin alpha v M ELISA, Flow Cyt, ICC/IF, IHC-P, IP Ms Hu ab16821

Integrin alpha v + beta 3 M BL, IP, IHC-Fr Ms Hu ab78289

Integrin beta 1 M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IHC-P, WB Rb Hu, Ms, Rat ab52971

Integrin beta 3 M Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, Inhib, WB Ms Hu ab7167

JNK1+JNK2 (phospho T183+Y185) P IHC-P, WB, ICC/IF, IHC-Fr Rb Hu, Ms, Predicted: Many ab4821

JNK1+JNK2+JNK3 P WB, ELISA Rb Hu, Ms, Rat ab59227

Laminin P Dot, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP Rb Hu, Ms, Mamm, Amph, Dog, Pig, Rept ab11575

MKK4 / MEK4 (phospho S80) P IHC-P, WB, ELISA Rb Hu, Ms, Rat ab39403

NFkB P ChIP, EMSA, ICC/IF, IHC-Fr, IHC-P, IP, WB Rb Hu, Ms, Rat ab7970

PAK1 M ICC/IF, IHC-P, IP, WB Rb Hu, Ms, Rat ab40795

PAK1+PAK2+PAK3 P IHC-P, ELISA Rb Hu, Ms, Rat ab59248

PECAM1 / CD31 M IP, WB, ICC/IF Ms Hu, Ms, Rat ab24590

PECAM1 / CD31 (APC) M BL, Flow Cyt, IP, IHC-Fr Rat Ms ab25563

PI 3 Kinase p85 alpha M Flow Cyt, ICC/IF, IHC-P, IP, WB Rb Hu, Rat ab40755

Rac1 P IHC-P, WB, ICC/IF Rb Hu, Ms ab78139

Rac2 P IHC-P, WB, ELISA Gt Hu ab2244

Src P IHC-P, WB, ELISA, ICC/IF Rb Hu, Ms, Rat ab47405

Src (phospho Y529) M IP, WB, ICC/IF, Dot Rb Hu, Ms, Rat ab32078

VCAM1 (FITC) M Flow Cyt, ICC/IF, FuncS, IP Rat Ms ab24853

VE cadherin M Flow Cyt, IHC-P, IHC-Fr, IP, Neut, WB, P, ICC/IF Ms Hu, Ms ab7047

Product

highlights

Integrin alpha 5 (ab6131)Clonality Applications M Flow Cyt, ICC/IF, IP Host Species cross reactivity Ms Hu

Integrin beta 1 (ab52971)Clonality Applications P Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IHC-P, WBHost Species cross reactivity Rb Hu, Ms, Rat

PAK1 (ab40795)Clonality Applications M ICC/IF, IHC-P, IP, WB Host Species cross reactivity Rb Hu, Ms, Rat

Laminin (ab11575)Clonality Applications P Dot, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IPHost Species cross reactivity Rb Hu, Ms, Dog, Pig, Xl

Fibronectin (ab6328)Clonality Applications M AP, ICC/IF, IHC-Fr, IHC-P, RIA, WBHost Species cross reactivity Ms Hu, Ms, Rat, Chk, Cow, Dog, Pig