Lupus eritematoso sitemico
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Transcript of Lupus eritematoso sitemico
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CONTENIDO
1. DEFINICION
2. EPIDEMIOLOGIA
3. ETIOPATOGENIA
4. MANIFESTACIONES CLINICAS
5. EXAMENES AUXILIARES
6. CRITERIOS DIAGNOSTICOS
7. TRATAMIENTO
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LUPUS ERITEMATOSO SISTÉMICO
DEFINICIÓN:
– Enfermedad autoinmune multisistémica crónica causada por la producción de autoanticuerpos y depósitos de complejos inmunes que dañan a células y tejidos.
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LUPUS ERITEMATOSO SISTÉMICO
EPIDEMIOLOGÍA:
– Incidencia de 2-8 x 100.000
– Relación mujer hombre 9:1
– Edad de inicio: 15 a 40 años
– > compromiso en raza negra
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LUPUS ERITEMATOSO SISTÉMICO
ETIOPATOGENIA:
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LUPUS ERITEMATOSO SISTÉMICO
ETIOPATOGENIA:
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
– SÍNTOMAS CONSTITUCIONALES
ANOREXIA ↓ PESO
ASTENIA FIEBRE
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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Artropatía de Jaccoud
LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
Eritema malar (LCA)
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
Lupus cutáneo subagudo (LCSA)
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
Lupus discoide (LCC)
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLINICAS:
Clasificación histológica de la nefropatía lupica según la OMS
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLINICAS:
Formas de la nefropatía lupica
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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LUPUS ERITEMATOSO SISTÉMICO
MANIFESTACIONES CLÍNICAS:
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LUPUS ERITEMATOSO SISTÉMICO
EXAMENES AUXILIARES: – AUTOANTICUERPOS
• Anticuerpos antinucleares (ANA)
• Anti DNA doble cadena
• Anti Smith
• Células LE
• Antifosfolipidos
• ENA: antígenos nucleares extractables
• Anti-Ro/La/RNP/Scl-70
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LUPUS ERITEMATOSO SISTÉMICO
EXAMENES AUXILIARES: – Hemograma
– Biopsia renal
– Análisis de orina
– Consumo de complemento: C3 y C4 – Radiografía
– ↑ VSG
– Factor reumatoide
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CRITERIOS
DIAGNOSTICOS
≥ 4 CRITERIOS
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RASH MALAR
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RASH DISCOIDE
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FOTOSENSIBILIDAD
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ULCERAS ORALES
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ARTRITIS
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SEROSITIS
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ENFERMEDAD RENAL
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TRASTORNOS NEUROLÓGICOS
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TRASTORNOS HEMATOLÓGICOS
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TRASTORNOS INMUNOLÓGICOS
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ANA (+)
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LUPUS ERITEMATOSO SISTÉMICO
TRATAMIENTO:
– LES NO AMENAZA LA VIDA: • AINES
– Ibuprofeno 400-800mg x 3 o 4 veces/d
• Antipalúdicos – Hidroxicloroquina 400mg/d
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LUPUS ERITEMATOSO SISTÉMICO
TRATAMIENTO:
– LES AMENAZA LA VIDA:
• Glucocorticoides sistémicos – Prednisona 1-2mg/Kg VO
– Metilprednisolona 500mg/d IV
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LUPUS ERITEMATOSO SISTÉMICO
TRATAMIENTO:
– LES AMENAZA LA VIDA:
• Fármacos Inmunosupresores
– Ciclofosfamida
– Metotrexate
– Azatioprina
– Micofenolato mofetilo
• Anticoagulantes
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LUPUS ERITEMATOSO SISTÉMICO
TRATAMIENTO:
– ESQUEMA GENERAL
• Fiebre: AINES!! + Antimalaricos
• Artritis!! Artralgias: AINES!! + Antimalaricos
• Serositis: AINES!! + Antimalaricos
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LUPUS ERITEMATOSO SISTÉMICO
TRATAMIENTO:
– ESQUEMA GENERAL
• Pulmonar: Glucocorticoides!! + Inmunosupresores
• Trombocitopenia: Glucocorticoides!! + Inmunosupresores
• Anemia hemolítica: Glucocorticoides!! + Inmunosupresores
• Nefritis: Glucocorticoides!! + Inmunosupresores
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LUPUS ERITEMATOSO SISTÉMICO
TRATAMIENTO:
– ESQUEMA GENERAL
• SNC: Glucocorticoides!! + Inmunosupresores
• Vasculitis: Glucocorticoides!! + Inmunosupresores
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LUPUS ERITEMATOSO SISTÉMICO