“Advances and Perspectives in

Neuroscience” “Avances y Perspectivas en Neurociencia”

Instituto de Investigaciones Biomédicas “Alberto Sols”- Facultad de Medicina Universidad Autónoma de Madrid

Madrid, April 22nd, 2016

Madrid, 22 de abril de 2016

INVITED SPEAKERS/PONENTES INVITADOS Francesc Artigas Instituto de Investigaciones Biomédicas de Barcelona Spain Jesús Ávila Centro de Biología Molecular Severo Ochoa Spain Josep Dalmau Institut d'Investigacions Biomèdiques August Pi i Sunyer Spain Luis Miguel García Segura Instituto Cajal Spain Eloísa Herrero Instituto de Neurociencias de Alicante Spain Eva-Maria Krämer-Albers Johannes Gutenberg University Germany Virginia M. Pickel Brain & Mind Research Institute, Cornell Medical College USA David Rubinsztein University of Cambridge United Kingdom Karl Zilles Research Center Jülich and RWTH University Aachen Germany

SPONSORS/PATROCINADORES Universidad Autónoma de Madrid Vicerrectorado de Investigación Fundación Universidad Autónoma de Madrid Decanato de la Facultad de Medicina www.uam.es Consejo Superior de Investigaciones Científicas Instituto de Investigaciones Biomédicas Alberto Sols www.cisc.es

Campus de Excelencia Internacional UAM-CSIC campusexcelencia.uam-csic.es CIBERNED www.ciberned.es The Company of Biologists www.biologists.com Sociedad Española de Neurociencia www.senc.es Fundación Alicia Koplowitz www.fundacionaliciakoplowitz.org

Fundación Teófilo Hernando www.ifth.es Cátedra UAM-Tatiana Pérez de Guzmán el Bueno www.catedra_Tatiana Cátedra UAM-Novartis en Neurociencias Clínicas www.catedra_Novartis Society for Neuroscience www.sfn.org Editorial Médica Panamericana www.medicapanamericana.com

PROGRAMME/PROGRAMA

08:00-12.00. Registration / Recogida de documentación

AULA MAGNA. FACULTAD DE MEDICINA

08:30-08:40. Opening / Apertura

08:40-10:00. Plenary Session 1 / Sesión Plenaria 1 Chairpersons / Moderadores: Manuela García-López (UAM) and Ana Montero-Pedrazuela (CSIC)

08:40-09:20 Reward in the mesolimbic system Virginia M. Pickel, New York, USA

09:20-10:00 Novel strategies in the treatment of major depression Francesc Artigas, Barcelona, Spain

10:00-10:40. Coffe & Poster viewing / Café y visita de paneles

10:40-12:00. Plenary Session 2 / Sesión Plenaria 2 Chairpersons / Moderadores: Carmen Cavada (UAM) and Pablo Rubio-Garrido (UAM)

10:40-11:20 What transmitter receptors can tell us about cortical organization Karl Zilles, Jülich, Germany

11:20-12:00 Molecular Mechanisms controlling the formation of Bilateral Circuits Eloísa Herrera, Alicante, Spain

12:00-12:45. Parallel poster sessions / Sesión simultánea de paneles

12:45-14:00. Lunch / Almuerzo

14:00-16:00. Plenary Session 3 / Sesión Plenaria 3 Chairpersons / Moderadores: Exuperio Díez-Tejedor (UAM), José Morales-García (CIBERNED/CSIC) and Soledad Bárez-López (CSIC)

14:00-14:40 Antibody mediated disorders of the synapse Josep Dalmau, Barcelona, Spain

14:40-15:20 Extracellular vesicles in neural cell communication: goodies for the brain Eva-Maria Krämer Albers, Mainz, Germany

15:20-16:00 Not only for sex: Estradiol as a neuroprotective factor Luis Miguel García-Segura, Madrid, Spain

16:00-16:40. Coffe & Poster viewing / Café y visita de paneles

16:40-18:00. Plenary Session 4 / Sesión Plenaria 4 Chairpersons / Moderadores: Isabel Lastres-Becker (UAM) y Ana Isabel Rojo (UAM)

16:40-17:20 Autophagy as a therapeutic target for neurodegeneration David Rubinsztein, Cambridge, UK

17:20-18:00 Recent developments in tau-based therapeutics for Alzheimer´s disease and related dementia Jesús Ávila, Madrid, Spain

18:00. Closing ceremony / Acto de clausura

Oral communications/Comunicaciones orales O1- Reward in the mesolimbic system O2- Novel strategies in the treatment of major depression O3- What transmitter receptors can tell us about cortical organization O4- Molecular Mechanisms controlling the formation of Bilateral Circuits O5- Antibody mediated disorders of the synapse O6- Exosomes in neural cell communication: goodies for the brain? O7- Not only for sex: Estradiol as a neuroprotective factor O8- Autophagy and other pathways that protect against neurodegeneration O9- Recent developments in tau-based therapeutics for Alzheimer´s disease and related dementia

Poster comunications/Comunicaciones en forma de panel

Poster session I: Structure and Function Sesión de paneles I: Estructura y Función P1- Modulation of sensory cortical areas by basal forebrain cholinergic neurons demonstrated by neuronal tracing and optogenetic stimulation in transgenic mice P2- Housing condition-related changes involved in reversal learning and its c-Fos associated activity in the prefrontal cortex P3- Convergent thalamic inputs to visual cortical areas in mice P4- Sensory interaction in the medial prefrontal cortex P5- Quantitative characterization of multivesicular bodies in the rodent somatosensory cortex P6- Development of orexinergic (hypocretinergic) system in the ontogeny of the CNS of Xenopus laevis P7- Quantitative analysis of perisomatic basket cell axon terminals in the human neocortex P8- Brain mechanisms for face perception and recognition: experimental studies developed with event-related potentials and neural source reconstruction methods P9- Uncovering diversity and cell fate potentials of NG2-glia P10- Noradrenergic innervation of the macaque monkey thalamus

P11- Sleep, EEG and behavioral responses after systemic administration of gaboxadol in the laboratory cat P12- Histamine interaction with the ventral part of the oral pontine tegmentum: Its implication in REM sleep modulation P13- Tuberomammillary histaminergic neurons modulate pontine tegmentum areas involved in wakefulness and REM sleep generation in the rat P14- Biofunctionalized microfibers for ultrasensitive neural recordings P15- Global Transcriptome Analysis of Primary Cerebrocortical Cells: Identification of Genes Regulated by Triiodothyronine in Specific Cell Types P16- Characterization of the properties of HEI-OC1 cells P17- Electromyographic analysis of the kinetic chains of Vojta´s reflex crawling

P18- A portrait of the transcriptome of the Inferior Colliculus of the GASH:Sal strain after one audiogenic seizure P19- Proteomic changes in the inferior colliculus of the GASH:Sal hamster

P20- Substantial differences in the in vitro response of rat DRG neurons and lizard retinal explants to recombinant Nogo-A-Fc and the protein kinase A inhibitor, KT5720 P21- Preliminary study on the relationship among physical activity, sex, BDNF and hippocampal volume in healthy elders P22- Specification of neuronal cell fate by different upstream cues acting on a common determination cascade

P23- How Can People Be so Good at Intercepting Accelerating Objects if They Are so Poor at Visually Judging Acceleration? P24- Incomplete recovery of visual functions after optic nerve axotomy in the lizard Galloti galloti P25- Retinal regeneration in sharks: an experimental approach P26- Chondroitin sulfate induces depression of synaptic transmission and modulation of neuronal plasticity in rat hippocampal slices P27- Insulin-like growth factor-1 increases postsynaptic excitability and induces long-term depression of excitatory synaptic transmission in layer V of rat infralimbic cortex P28- IGF-I mediated nitric oxide and endocannabinoid dependent dual modulation of synaptic transmission at barrel cortex synapses P29- Endocannabinoid mediated long-term potentiation of synaptic transmission at rat barrel cortex

Poster session II: Brain Diseases Sesión de paneles II: Enfermedades Cerebrales P30- Increased Alzheimer’s disease-like pathology in immunosuppressed APP/PS1 transgenic mice P31- Interactions between amyloid plaques and glial cells: an ultrastructural study in the APP/PS1 Alzheimer’s model hippocampus P32- Characterizing beta-amyloid plaque properties in the hippocampus of APP751SL/ PS1M146L Alzheimer mice P33- Lack of transcription factor Nrf2 aggravates combined TAU and beta-Amyloid pathology P34- Role of the transcription factor NRF2 in the regulation of macroautopahgy and its impact in a new mouse model of AD P35- Study on ageing and the mild stages of Alzheimer’s disease regarding neural networks in facial processing by means of N170-VPP P36- Modulation of PKA and PKC in the frontal cortex of Alzheimer’s disease human brains P37- Trehalose effects on TAU uptake and degragdation by glial cells in culture P38- Amyloid-β(1-40) and (1-42) effects on the differentiation of human neural stem cells P39- Amyloid precursor protein expression regulates the neuronal differentiation of Human Neural Stem Cells P40- Female PSGL-1 KO mice spontaneously develop pulmonary arterial hypertension P41- Multitarget Cannabinoid agonists normalize survival pattern of lymphoblasts from late-onset Alzheimer’s disease patients P42- Role of glial cells in an in vitro model of Alzheimer´s disease that combines βA and Tau pathology P43- Role of the redox signaling in self-renewal and multipotency of neural stem cells: implications in aging and Alzheimer´s Disease

P44- Dual role of the p75 neurotrophin receptor in the basal forebrain of the SAMP8 mouse P45- Role of the CB1 receptor in the sensitivity of direct vs indirect corticostriatal pathways to mutant Huntingtin toxicity P46- What´s New in Research and Treatment of Spinal Muscular Atrophy? P47- Ultrastructural changes in chromaffin cells from the SOD1G93A mouse model of amyotrophic lateral sclerosis may explain the altered fusion pore kinetics P48- Spinal cord injury induces an increase in the expression of the serotonin 1a receptor in spinal-projecting neurons of low regenerative ability P49- Influence of the Met129Val human PrP dimorphism in the transmission barrier to BSE/vCJD prions P50- Adenosine receptors are alterated in neonatal cerebellum from a rat model of febrile seizures P51- Efferent projections from the inferior colliculus to brainstem motor nuclei in the Genetic Audiogenic Seizure Hamster (GASH:Sal) P52- Diagnostic value of early socioaffective behavior of children with primary autism

P53- Neurocognitive approach to prosopagnosia spectrum disorders: Neuropsychological findings of a case of acquired prosopagnosia and one of developmental prosopagnosia P54- Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats P55- Neurofeedback training for brain damaged patients with apperceptive or amnesic associative agnosia P56- Possible antiinflammatory role of perivascular macrophages in a model of depression induced by chronic mild stress in rats P57- Impaired spatial memory and in vivo long-term potentiation induction in old aged male Wistar rats after long-term social isolation P58- Effect of thyroid hormone treatment in performance of socially and spatially dependent tasks by aging mice P59- Co-occurring depressive symptoms in patients aged over 65 years with Schizophrenia

P60- Relationship between insight, treatment adherence, socio-demographic and clinical variables in outpatients with Schizophrenia P61- The effects of prenatal stress are only revealed after exposure to a mild session of footshocks in rats

P62- Dopaminergic neurons intrinsic to the striatum: potential compensatory mechanism in Parkinson's Disease? P63- Mesencephalic dopamine cell groups in long-evolution parkinsonian macaques without motor symptoms P64- Igf1 haploinsufficiency in mice increases noise-induced cochlear injury by altering antioxidant and inflammatory response P65- Transforming growth factor β1 inhibition protects from swept-sine-violet noise-induced damage P66- Characterization of the stress response induced by audiogenic seizures in the GASH:Sal

P67- Now you see it, now you don't: Visual memory impairment in a case of herpex simplex encephalitis P68- Analysis of NFATc3 role on proliferation and migration of U373 glioma cells in vitro and in Xenografts P69- CRB2 concludes cellular polarization by regulating cell cycle arrest and cell junctions formation

Poster session III: Frontiers and Strategies in Brain Therapies Sesión de paneles III: Fronteras y Estrategias en Terapias Cerebrales P70- Repurposing the NRF2 activator dimethyl fumarate as therapy against synucleinopathy in Parkinson’s disease P71- An Update on Stem-Cell Based Therapies in Parkinson’s Disease P72- Full anatomical recovery of the dopaminergic system after a complete spinal cord injury in lampreys P73- Targeting CB2 and PPAR-γ receptors with phytocannabinoid derivatives for a neuroprotective therapy in amyotrophic lateral sclerosis P74- The basal ganglia: a new possible therapeutic target in the Allan-Herndon-Dudley Syndrome P75- First approach to intranasal-delivered thyroid hormone replacement therapy in the Allan-Herndon-Dudley Syndrome P76- Intranasal insulin treatment attenuates methamphetamine-induced neuroinflammation and cognitive impairment P77- Syndrome of Inappropriate Antidiuretic Hormone associated with Fluphenazine Decanoate P78- Improvement of mitochondrial Na+/Ca2+ exchanger blockade and neuroprotective profile of 4,1-benzothiazepines P79- Perinatal brain damage, neuroplasticity and early intervention: a case report P80- Delayed induction of vascular remodelling by acute artery recanalization in mice following stroke P81- Neuroprotective properties of a new hybrid between nimodipine and a CGP-37157-analogue in cerebral ischemia models P82- Electrophysiological characterization of new selective KChIP3 modulators P83- A comparative study of drug delivery methods targeted to the mouse inner ear: bullostomy versus transtympanic injection P84- Effects of the environmental enrichment on disruptions caused by prenatal stress in rats P85- PKD1 as a possible therapeutic target in neurodegenerative diseases P86- Therapeutic agents for the treatment of neurodegenerative diseases: Nrf2 as central player

P87- Microtubule stabilizing therapy protects cognitive function and ameliorates Alzheimer’s disease pathology

P88- First GSK3β inhibitors and Nrf2 inducers for the treatment of Alzheimer’s disease: a new family of multitarget compounds P89- Drug repositioning as a strategy to develop a treatment for Alzheimer´s disease P90- 3-Iodothyronamine rescues synaptic dysfunction induced by β-amyloid: a TAAR1-mediated action P91- Generation of induced pluripotent stem cells (IPSCS) using non-integrative vectors: potential applications in regenerative therapies P92- Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects P93- Microfibers composed of partially reduced graphene oxide as an attractive platform for neural cell growth

P94- Regenerating lizard RGC increase intracellular cAMP and their axons regrow along the visual pathway despite the presence of Nogo-A and upregulation of NgR P95- Testosterone fails to protect against inflammation and stress produced by lipopolysaccharide treatment in hypothalamic astrocytes

P96- Rubik’s cube experts do not seem to improve their Visual Working Memory capacity, nor increase their Contralateral Delay Activity, with training. A preliminary study P97- Impact of anesthetic drug on seizure duration in Electroconvulsive Therapy (ECT) P98- Neuroprotective statins effect in retina: A hypercholesterolemic rabbit model P99- Alterations of the cholesterol homeostasis in a neuronal model of HSV-1 infection and induction of oxidative stress P100- Autophagy in the mouse inner ear: an age-related function P101- Effects of maternal diabetes on spatial memory and neuronal and astroglial hippocampus alterations in their adult offspring P102- The response of hypothalamic astrocytes from male and female Wistar rats to saturated and unsaturated fatty acids P103- Resveratrol modulates adenosine receptors endogenously expressed in C6 glioma cells P104- Differential entrainment susceptibility of central and peripheral circadian clocks affecting energy metabolism in Pitx3-deficient Aphakia mice P105- Alcohol binge alters blood TLR4 and proinflammatory cytokines/chemokines in women but no men young drinkers P106- High folic acid supplementation in maternal diet perturbs vascular spinal cord development in mouse P107- Melatonin protects against the inhibition of autophagy due to Tau hyperphosphorylation in ex vivo and in vivo models P108- Reactive oxygen species production in acute hypoxia: oxygen sensing by mitochondrial complex I and the role of the sodium/calcium exchanger NCLX P109- Calcium stores contribute to the regulation of vesicle transport and exocytosis in mouse chromaffin cells repeatedly challenged with acetylcholine P110- Physician Eye Contact: A Pilot Study Using Portable Eye Tracking Equipment in the Ambulatory Clinic to Measure Physician Patient Interaction P111- Phenotypic changes of microglia associated to aging in a mouse model of accelerated senescence: the SAM P8 mice