DISLIPIDEMIAS

Funciones de los lípidos

• Función de reserva. • Función estructural. • Función biocatalizadora. • Función transportadora.

Estructura de la membrana celular

CLASIFICACIÓN Y COMPOSICIÓN DE LAS LIPOPROTEÍNAS

Estructura de VLDL

Las vias metabólicas exógenas y endógenas de las lipoproteínas

Metabolismo de las HDL y transporte inverso de colesterol

fenotipo 1 IIa II b III IV V

Lipoproteína

Quilo-micrones

LDL LDL y VLDL

Restos de quilomicrones y VLDL

VLD quilomicrones y VLDL

Triglicéridos ++++ -- ++ ++ a +++ ++ ++++

Colesterol + a++ +++ ++ a +++ ++a+++ --a + ++ a +++

C-LDL ↓ ↑ ↑ ↓ ↓ ↓↓

C- HDL +++ + ++ ++ ++ +++

Aspecto del plasma

Lechoso Claro Claro Turbio Turbio Lechoso

Xantomas Eruptivos Tendones, tuberoso

Ninguna Palmares, tuberoeruptivos

Ninguna Eruptivo

Pancreatitis +++ 0 0 0 0 +++

Aterosclerosis coronaria

0 +++ +++ +++ +/- + / -

Aterosclerosis periférica

0 + ++ + + + / - + / -

Nomenclatura genética

FCS FH, FDB, ADH, ARH,

FCHL FDBL FHTG FHTG

Criterios Med-Ped de Hipocolesterolemia Familiar

Criterios diagnósticos de Hiperlipemia Familiar Combinada

GUIAS CLÍNICAS DE LA SOCIEDAD GALLEGA DE MEDICINA INTERNA

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

(Zocor)

(Mevacor)(Pravacol)

(Lescol)(Lipitor)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

( LOPID )( CONTROLIP ) ( HIPERLIPEN )

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)