Emtricitabine/vinblastine
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Reactions 1451 - 11 May 2013 Emtricitabine/vinblastine Recurrent laryngeal nerve palsy: case report A 48-year-old man developed recurrent laryngeal nerve palsy while receiving vinblastine and emtricitabine. The man had been diagnosed with HIV infection in 2008, and had subsequently started antiretroviral therapy which included emtricitabine [dosage, route and duration of therapy not stated]. After presenting with weight loss in May 2012, he was diagnosed with stage 4B Hodgkin’s lymphoma and he started receiving four-weekly vinblastine [dosage and route not stated] with doxorubicin, bleomycin and dacarbazine. He reported hoarseness of voice 2 weeks after starting the treatment. Flexible nasoendoscopy confirmed paralysis of his left vocal cord in the lateral position [outcome not stated]. Author comment: "We report a man with AIDS who developed hoarseness of voice due to [recurrent laryngeal nerve] palsy during treatment with vinblastine for Hodgkin’s lymphoma. . . The co-administration of potential neurotoxic antiretroviral drugs such as emtricitabine in his combination may have exacerbated neurotoxicity." Cherif S, et al. An unusual cause of hoarseness of voice in an AIDS patient. HIV Medicine 14: 44, Apr 2013. Available from: URL: http:// dx.doi.org/10.1111/hiv.12027 [abstract] - United Kingdom 803086456 1 Reactions 11 May 2013 No. 1451 0114-9954/10/1451-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Emtricitabine/vinblastine
Reactions 1451 - 11 May 2013
Emtricitabine/vinblastine
Recurrent laryngeal nerve palsy: case reportA 48-year-old man developed recurrent laryngeal nerve
palsy while receiving vinblastine and emtricitabine.The man had been diagnosed with HIV infection in 2008,
and had subsequently started antiretroviral therapy whichincluded emtricitabine [dosage, route and duration of therapynot stated]. After presenting with weight loss in May 2012, hewas diagnosed with stage 4B Hodgkin’s lymphoma and hestarted receiving four-weekly vinblastine [dosage and route notstated] with doxorubicin, bleomycin and dacarbazine. Hereported hoarseness of voice 2 weeks after starting thetreatment. Flexible nasoendoscopy confirmed paralysis of hisleft vocal cord in the lateral position [outcome not stated].
Author comment: "We report a man with AIDS whodeveloped hoarseness of voice due to [recurrent laryngealnerve] palsy during treatment with vinblastine for Hodgkin’slymphoma. . . The co-administration of potential neurotoxicantiretroviral drugs such as emtricitabine in his combinationmay have exacerbated neurotoxicity."Cherif S, et al. An unusual cause of hoarseness of voice in an AIDS patient. HIVMedicine 14: 44, Apr 2013. Available from: URL: http://dx.doi.org/10.1111/hiv.12027 [abstract] - United Kingdom 803086456
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Reactions 11 May 2013 No. 14510114-9954/10/1451-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
