7/21/2019 102 melanoma 500 2013

1/6

http://localhost/var/www/apps/conversion/tmp/scratch_2/dx.doi.org/10.1016/j.oftal.2013.06.003mailto:nelvit@yahoo.eshttp://www.elsevier.es/oftalmologiahttp://localhost/var/www/apps/conversion/tmp/scratch_2/dx.doi.org/10.1016/j.oftal.2013.06.003

7/21/2019 102 melanoma 500 2013

2/6

7/21/2019 102 melanoma 500 2013

3/6

7/21/2019 102 melanoma 500 2013

4/6

7/21/2019 102 melanoma 500 2013

5/6

http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0045http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0040http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0035http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0030http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0025http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0020http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0015http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0010http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0005

7/21/2019 102 melanoma 500 2013

6/6

http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0120http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0115http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0110http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0100http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0095http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0090http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0085http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0080http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0075http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0070http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0065http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0060http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0055http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050http://refhub.elsevier.com/S0365-6691(13)00227-X/sbref0050